Risk Assessment of Cadmium Toxicity on Hepatic and Renal Tissues of Rats

Novelli, Ethel L. B.; Vieira, Eliane Passarelli; Rodrigues, N. L.; Ribas, B.

doi:10.1006/enrs.1998.3865

Cited by 44 publications

(23 citation statements)

References 28 publications

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“…Cadmium is a highly toxic heavy metal, since it causes deleterious effects in organisms at low levels of exposure (Cope et al, 1994). Various toxic effects of cadmium have been reported, as well as its accumulation in liver (Novelli et al, 1998), kidney (Klaassen & Liu, 1997;Novelli et al, 1999) and testes (Shen & Sangiah, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…However, in certain conditions such as cadmium exposure (Novelli et al, 1998), electron flow may become uncoupled, leading to the production of reactive oxygen species (ROS). Reactive oxygen species, superoxide anion (O 2 -), hydroxyl radicals (OH · ) and hydrogen peroxide (H 2 O 2 ) can elicit widespread damage to cells, such as lipoperoxidation of polyunsaturated membrane lipids.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination

et al. 2009

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The objective of this study was to investigate the possible link between cadmium exposure, hepatic markers of oxidative stress and aggressive behavior in Nile tilapia (Oreochromis niloticus). Fish were first exposed to 0.75 mg/L CdCl 2 for 15 days (12 isolated fish for each group) and afterward a behavioral test was performed. Fish from the control and cadmium-exposed groups were paired for 1 h (6 pairs of fish per group) for determination of aggressiveness parameters. Immediately after the behavioral test, the animals were sacrificed and the liver was used to determine biochemical parameters. Cadmium decreased aggression in Nile tilapia. Subordinate animals exposed to cadmium showed decreased glutathione peroxidase (GSH-Px) activity compared to dominant ones. No alterations were observed in selenium-dependent glutathione peroxidase Se-GSH-P and Cu-Zn superoxide dismutase activities, but total superoxide dismutase activity was increased in subordinate animals exposed to cadmium compared to subordinate control. Catalase activity was increased in cadmium-exposed fish. Lipoperoxide concentrations also increased in cadmium exposed fish indicating that cadmium toxicity may affect oxidative stress biomarkers in Nile tilapia. Social stress induced lipoperoxidation in Nile tilapia, and subordinate animals exposed to cadmium responded with lower activities of liver antioxidant enzymes compared to dominant fish. The present study shows that cadmium exposure is capable of inducing changes in the social status and oxidative stress parameters in this species.O objetivo deste estudo foi investigar a possível relação entre a exposição ao cádmio, os marcadores hepáticos de estresse oxidativo e o comportamento agressivo em tilápia do Nilo (Oreochromis niloticus). Os peixes foram primeiramente expostos à concentração de 0,75 mg/L de CdCl 2 durante 15 dias (12 peixes isolados em cada grupo), após o qual o teste de comportamento foi aplicado. Peixes do grupo controle e do grupo exposto ao cádmio foram pareados durante 1 hora (6 pares de peixes por grupo) para determinação de parâmetros de agressividade. Imediatamente após o teste comportamental, os animais foram sacrificados e o fígado foi coletado para as determinações bioquímicas. O cádmio diminuiu a agressão em tilápias do Nilo. Animais subordinados e expostos ao cádmio mostraram uma redução na atividade da enzima glutationa peroxidase (GSH-Px), quando comparados aos dominantes. Nenhuma alteração foi observada na atividade da glutationa peroxidase dependente de selênio (Se-GSH-P) e na superóxido dismutase Cu Zn, mas a atividade total da superóxido dismutase aumentou em animais subordinados e expostos ao cádmio, quando comparado ao controle subordinado. A atividade da catalase aumentou em peixes expostos ao cádmio. As concentrações de lipoperóxido aumentaram em peixes expostos ao cádmio, indicando que a toxicidade deste pode afetar os biomarcadores de estresse oxidativo em tilápias do Nilo. O estresse social induziu lipoperoxidação em tilápia do Nilo e animais subordinados e expo...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination

et al. 2009

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“…Biochemical changes occur earlier to structural alteration in the body systems. Moreover, the changes in defined activities of enzymes within the body fluids could replicate the expansion of Cd-incited damages in the goal organs [11][12][13]. Exploring the effects of Cd compounds on birds is a subject extensively studied in eco-toxicological surveys [14].…”

Section: Introductionmentioning

confidence: 99%

Histological and Functional Alteration in the Liver and Kidney and the Response of Antioxidants in Japanese quail Exposed to Dietary Cadmium

Karimi

Hesaraki

Mortazavi

2017

IJT

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Background:The aim of the present study was to find the effects of cadmium (Cd) on Japanese quail on the role of an animal model in order to understand the toxicity of Cd in creatures presented, within the environment. Methods:One hundred 30-day-old male Japanese quails were equally divided into the control group and Cd group. The control group received no Cd while the Cd group was given formula feed comprised of 100 ppm of Cd (CdCl2, Merck, Germany) for sixty days. The histological and functional alteration in the liver and kidneys and the response of antioxidants were determined.Results: Histological changes in the liver increased the number of kuppfer cells, vacuolar degeneration, and hepatocytes single cell necrosis in the Cd group. The renal histopathological changes were hyaline cast in renal tubules and necrosis and swelling of tubular epithelial cells. The level of aminotransferases (ALT and AST), blood urea nitrogen (BUN) and creatinine rose significantly in the Cd group toward the control group (P<0.05). The antioxidants (SOD, CAT and GSH) levels considerably diminished, while lipid peroxidation proliferated substantially in the hepatic and renal tissues of Japanese quails in the CD group (P<0.05). Conclusion:Presentation to dietary Cd (100mg/kg diet) for 60 reduces the body weights gain and induces the histological and functional alteration in the liver and kidneys of Japanese quail as well as cellular antioxidant alterations.

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“…(Casalino et al 2002). The catalase activity in liver decelerates due to binding of Cd to imidazole group of His-74 which is essential in the decomposition of hydrogen peroxide (Casalino et al 2002) and Cu-Zn super oxide dismutase (Cu-Zn SOD) activity also decreased greatly (Novelli et al 1998). At a concentration beyond 200 ppb, it is toxic to certain fishes, such as Oreochromis mossambicus, Oncorhynchus mykiss, Brycon cephalus, etc.…”

Section: Introductionmentioning

confidence: 99%

Seasonal distribution of cadmium among components of sewage treatment ponds: an eco-tech for heavy metal remediation

Rana

Bag

Jana

2013

Int. J. Environ. Sci. Technol.

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The study was designed to quantify cadmium accumulation in different components of sewage treatment ponds during different seasons and to assess risk for human consumption perspective. The study estimated cadmium concentration in water, sludge, Eichhornia, plankton and tilapia fish from anaerobic, facultative, maturation-1 and -4 ponds during pre-monsoon, monsoon and post-monsoon periods. It resulted that cadmium accumulated among different components of anaerobic, facultative, maturation-1 and -4 ponds ranging 0-18, 0-10, 0-7 and 0-15.4 ppb, respectively. During monsoon, highest accumulation was observed in tilapia in both facultative and maturation ponds, but during post-monsoon, plankton community showed highest value in all. The highest bio-magnification of cadmium was recorded during monsoon with varying degrees (facultative pond: 4.39, maturation pond-1: 3.03 and maturation pond-4: 7.08). Cadmium concentration in tilapia lied within WHO's safe level and may be recommended for human consumption. The concentration of cadmium was estimated by Flame Atomic Absorption Spectrophotometer. The above findings occurred due to chelation, adsorption and sedimentation, absorption and bio-accumulation, ionization, leaching through sediment and rainfall. Water pH (6.7-8.8), dissolved oxygen (0-17 mg L -1 ), total solids (251-650 mg L -1 ), iron (Fe 2? ) concentration (0.61-4.87 mg L -1 ) and sedimentation rate (278.9-2,409.6 g day -1 m -3 ) were conducive for the distribution of cadmium into different ecosystem components of treatment ponds. These ponds reclaimed 28.57-61.11 % of sewage-cadmium and may be promoted as a low-cost eco-tech for sewage treatment.

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Risk Assessment of Cadmium Toxicity on Hepatic and Renal Tissues of Rats

Cited by 44 publications

References 28 publications

Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination

Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination

Histological and Functional Alteration in the Liver and Kidney and the Response of Antioxidants in Japanese quail Exposed to Dietary Cadmium

Seasonal distribution of cadmium among components of sewage treatment ponds: an eco-tech for heavy metal remediation

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