Risk Assessment of Hepatocellular Carcinoma in Chronic Hepatitis C Patients by Transient Elastography

Masuzaki, Ryota; Tateishi, Ryosuke; Yoshida, Haruhiko; Yoshida, Hideo; Sato, Shinpei; Kato, Naoya; Kanai, Fumihiko; Sugioka, Yosuke; Ikeda, Hitoshi; Shiina, Shuichiro; Kawabe, Takao; Omata, Masao

doi:10.1097/mcg.0b013e318050074f

Cited by 79 publications

(61 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even in so-called ''cirrhotic'' patients, the possibility of HCC presence was elevated slightly when the liver stiffness was less than 24 kPa. However, once the stiffness exceeded 24 kPa, this possibility rose steeply, which was comparable with the report on patients with HCV by Masuzaki et al [13]. He pointed out that the possibility of HCC presence in HCV-related cirrhosis patients increases from 1.3-to 5-fold when the liver stiffness is higher than 25 kPa.…”

Section: Discussionsupporting

confidence: 74%

“…Liver stiffness measurement (LSM) by TE is a rapid, non-invasive, reproducible and operator-friendly method, which has been reported as accurately representing the state of liver fibrosis [8][9][10][11][12]. It was recently proposed to assess the risk of HCC development in patients with chronic HCV infection by TE [13]. The aim of this study was to assess the relationship between liver stiffness and the risk of HCC presence in patients with chronic hepatitis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis

Kuo

Hung

et al. 2010

Hepatol Int

View full text Add to dashboard Cite

Backgroud/aims The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. Methods The patients with liver tumor or chronic hepatitis indicated for biopsy were prospectively enrolled. LSM was performed on the same day as biopsy. The diagnostic performances of clinical parameters and LSM in predicting HCC presence were compared with the areas under receiver operating characteristics curves (AUROC). The risk of HCC presence was assessed with stratum-specific likelihood ratios (SSLR). The cut-off values and its diagnostic validity were calculated for LSM. Results A total of 435 patients, including 106 HCC and 329 chronic hepatitis, were enrolled. The AUROC in predicting HCC presence was 0.736, 0.733, 0.594, 0.579 and 0.532 for LSM, alpha-fetoprotein, platelet count, total bilirubin, and aspartate aminotransferase-platelet ratio index, respectively. Multivariate analysis showed liver stiffness was an independent factor for HCC presence (odds ratio 1.07, 95% confidence interval (CI) 1.05-1.09). SSLR for HCC presence by liver stiffness was 0.43 (95% CI 0.32-0.57) in\12 kPa, in [24 kPa. With 12 and 24 kPa as the cut-offs in predicting HCC presence, the sensitivity was 69.8 and 41.5%, respectively. The specificity was 69.6 and 92.7%, respectively. Conclusions LSM identified the risk group for HCC presence in chronic hepatitis patients and had high specificity in the prediction of HCC with the cut-off of 24 kPa.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis

Kuo

Hung

et al. 2010

Hepatol Int

View full text Add to dashboard Cite

show abstract

“…The rate of chronicity after acute HCV infection is above 80% (Alter et al, 1992;Seeff, 1995), and some patients will ultimately develop liver cirrhosis and hepatocellular carcinoma (Gane, 2008;Kwon and Bae, 2008;Masuzaki et al, 2008). Due to the high mutation rate of the HCV genome, effective vaccines have not yet been developed.…”

Section: Introductionmentioning

confidence: 99%

Role of Th1/Th2 cytokines in serum on the pathogenesis of chronic hepatitis C and the outcome of interferon therapy

Zhang¹,

Hao²,

Liang³

et al. 2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The aim of this study was to investigate the role of T-helper cell (Th)1/Th2 cytokines in the chronicity of hepatitis C virus (HCV) infection and the outcome of interferon (IFN) alpha therapy. A total of 30 patients with chronic hepatitis C were enrolled in the study. The levels of Th1/Th2 cytokines were determined. The differentiation of HCV genotypes was determined by direct sequencing. HCV RNA loads were detected by fluorescence quantitative polymerase chain reaction (qPCR). In chronic hepatitis C, the levels of interleukin (IL)-2 and transforming growth factor (TGF)-b significantly decreased, and IL-5 and IL-18 levels increased compared with normal controls. The IL-6 serum levels were directly proportional to the serum levels of alanine aminotransferase, and were inversely proportional to the HCV RNA loading levels. Patients with severe hepatitis C had higher levels of IL-4, IL-6, and IL-1b compared to milder cases. Patients with genotype 1 showed higher serum levels of IL-6 than those with genotype 2. The levels of IL-2 and IL-18 showed a decreasing tendency, whereas TGF-b, IL-6, and IL-1b showed an increasing tendency over time. There was no difference in any cytokines detected between the response and nonresponse groups before IFN therapy. However, the IFN-g level increased after IFN therapy in the response group. There was no correlation between the Th1/Th2 cytokine levels in the serum before IFN treatment and in the outcome of IFN therapy. Increasing IFN-g levels in the serum induced by IFN treatment is associated with systemic vascular resistance.

show abstract

“…In shear wave elastography, the measurement of liver stiffness (LS) is affected greatly by the severity of inflammation, jaundice and congestion besides liver fibrosis [12,13,14,15,16]. In addition, LS is highly correlated with the risk of liver cancer in chronic hepatitis patients [17,18,19]. Although a study using shear wave elastography with the employment of FibroScan reported that LS was improved by interferon (IFN) therapy [20], the association between strain elastography and antiviral therapy has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Elastography Correlates Treatment Response by Antiviral Therapy in Patients with Chronic Hepatitis C

Yada

Sakurai²,

Minami³

et al. 2014

Oncology

View full text Add to dashboard Cite

Objective: To investigate the relationship between tissue elasticity before and after antiviral therapy and shear wave as well as strain elastography. Methods: FibroScan and real-time tissue elastography were performed before and after antiviral therapy for chronic hepatitis C, and treatment efficacy and elastographic findings were comparatively analyzed. Elasticity was evaluated by measuring liver stiffness (LS) in kilopascals using FibroScan, and the liver fibrosis index (LFI) was assessed by real-time tissue elastography. Results: LS and LFI correlated well before and after therapy (r = 0.567, p = 0.003 and r = 0.576, p = 0.002, respectively). In the group without a sustained virological response (SVR), LS increased in 4 of 5 patients. Patients with an increase in both LS and LFI were all in the non-SVR group (3/3, 100%). In addition, LS increased in all patients except 1 in the non-SVR group (4/5, 80%). In the SVR group, both LS and LFI decreased in all patients except 1 (18/19, 94.7%). In the patient with an increase in LS despite achieving SVR, LS decreased quickly after alcohol cessation. Conclusions: With a few exceptions, SVR improved LS. All patients with an increase in LFI were in the non-SVR group, even though LFI decreased in 2 patients. Our findings suggest that an LFI increase indicates lack of treatment efficacy with antiviral therapy. LFI may be useful for the assessment of treatment efficacy in patients with worsening of LS despite achieving SVR with antiviral therapy.

show abstract

Risk Assessment of Hepatocellular Carcinoma in Chronic Hepatitis C Patients by Transient Elastography

Abstract: Liver stiffness measured by transient elastography is useful in demarcating chronic hepatitis C patients at a high risk for HCC, who require frequent check-up by imaging examinations.

Cited by 79 publications

References 24 publications

Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis

Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis

Role of Th1/Th2 cytokines in serum on the pathogenesis of chronic hepatitis C and the outcome of interferon therapy

Ultrasound Elastography Correlates Treatment Response by Antiviral Therapy in Patients with Chronic Hepatitis C

Contact Info

Product

Resources

About