Risk assessment of the cumulative acute exposure of Hungarian population to organophosphorus pesticide residues with regard to consumers of plant based foods

Zentai, Andrea; Szabó, I.; Kerekes, Kata; Ambrus, Árpád

doi:10.1016/j.fct.2016.01.016

Cited by 29 publications

(6 citation statements)

References 7 publications

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“…An acute risk assessment study on Polish vegetables also showed potentially hazardous contingencies [80]. Zuo [82,83]. Our study showed that there was no acute risk of dietary exposure from Chinese cabbage, while pakchoi presented an acute risk of dietary exposure.…”

Section: Acute Dietary Risk Assessment Of Two Major Leafy Vegetablesmentioning

confidence: 49%

Pesticide Residues in Greenhouse Leafy Vegetables in Cold Seasons and Dietary Exposure Assessment for Consumers in Liaoning Province, Northeast China

Wang,

Li,

Zhang

et al. 2024

Agronomy

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Excessive pesticide application in greenhouses leads to elevated levels of pesticide residues, especially in cold seasons, thereby posing a potential dietary exposure risk to the residents’ health. This study aimed to investigate 65 pesticides in 469 leafy vegetable samples collected from greenhouses in Liaoning province between October 2018 and May 2020. Overall, the pesticide levels in 96.4% (452/469) of the samples were below the MRLs established by the Codex Alimentarius Commission. The detection rate of 65 pesticides ranged from 0.2% to 11.9%. Multiple pesticide contamination was common, with dimethomorph being the most recurrent contaminant. The dietary risk assessment study revealed obvious differences in chronic and acute exposure risk values. The chronic risk quotients (RQcs) for leafy vegetable samples were 0.001%–3.993%, indicating an acceptable public health risk for the residents. As two leafy vegetables highly consumed in cold seasons in northeast China, the acute risk quotients (RQas) of Chinese cabbage samples were significantly lower than 100%; however, pakchoi samples exhibited RQa values ranging from 0.159% to 580.529%, showing an unacceptable acute dietary risk. This highlights that, compared to the chronic dietary risks, the potential acute dietary risks induced by the pesticides are higher in greenhouse-grown leafy vegetables during cold seasons.

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Section: Acute Dietary Risk Assessment Of Two Major Leafy Vegetablesmentioning

confidence: 49%

Pesticide Residues in Greenhouse Leafy Vegetables in Cold Seasons and Dietary Exposure Assessment for Consumers in Liaoning Province, Northeast China

Wang,

Li,

Zhang

et al. 2024

Agronomy

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“…The general categories of co-exposure toxic actions are additive, more than additive (synergism or potentiation), and less than additive (antagonism, inhibition, or masking), based on the doseresponse relationship and interaction mechanism of the individual chemicals (2004a; 2004b). It has been globally recognized that cumulative risk assessment after co-exposure to chemical mixtures is of crucial importance (Scholze et al, 2015;Quijano et al, 2016;Tsatsakis et al, 2016;Zentai et al, 2016); however, it should be noted that there is no universally applicable method for such risk assessments. For instance, benzoapyrene was used as a surrogate chemical by JECFA to evaluate 13 types of carcinogenic polycyclic aromatic hydrocarbons (PAHs) in food using a surrogate approach (WHO, 2006).…”

Section: Discussionmentioning

confidence: 99%

Novel Integrated Tiered Cumulative Risk Assessment of Heavy Metals in Food Homologous Traditional Chinese Medicine Based on a Real-Life-Exposure Scenario

et al. 2022

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In order to serve population health better, the first integrated tiered decision tree for cumulative risk assessment of co-exposure of Pb-, Cd-, and As-associated health risks in food homologous traditional Chinese medicine (TCM) was designed, after measuring their concentrations by inductively coupled plasma-mass spectroscopy (ICP-MS). Basically, our three-step decision tree involving hazard quotient (HQ), hazard index (HI), and target-organ toxicity dose (TTD) modification of the HI method was developed to evaluate the potential risks of 949 batches of 15 types of food homologous TCM. To acquire a real-life exposure scenario, the cumulative risk assessment model was established by optimizing key parameters, such as ingestion rates, frequency, and duration of exposure to food homologous TCM based on questionnaire data. As a result, the mean concentrations of Pb, Cd, and As in 949 batches of food homologous TCM were 0.896, 0.133, and 0.192 mg/kg, respectively. The HQ values of As for Angelica sinensis (Oliv.) Diels and Houttuynia cordata Thunb. were 1.04 and 1.01, respectively, for females. Other HQs of Pb, Cd, or As in food homologous TCM were lower than 1 for both males and females. However, after rapid screening of the co-exposure health risks of heavy metals by the HI method, cumulative risk assessment results acquired by TTD modification of the HI method implied that the potential health risks associated with the co-exposure of Pb, Cd, and As in Lonicera japonica Thunb. and Houttuynia cordata Thunb. ingested as both TCM and food were of concern in the clinic. Additionally, the cumulative risks of Pb, Cd, and As in Mentha canadensis L., Chrysanthemum indicum L., and Zaocys dhumnades (Cantor) only used as food exceeded the human tolerance dose. Collectively, our innovation on the tiered strategy of decision tree based on a real-life exposure scenario provides a novel approach engaging in the cumulative risk assessment of heavy metals in food homologous TCM. All in all, such effort attempts to scientifically guide the rational use of TCM in the treatment of the complex diseases and the improvement of population health.

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“…The average frequencies were 29% (2018), 28% (2019), and 28.9% (2020) of the samples analyzed within the national and European coordinated residue testing programs. The maximum number of residues was found in a strawberry sample (35) in 2020 and a dried vine fruit sample (28) in 2020 [14].…”

Section: Introductionmentioning

confidence: 96%

“…The cumulative risk of organophosphorus, carbamate insecticides, and triazole fungicides was assessed by applying the relative potency factors [25], for instance, using the Brazilian, Chinese, German, Hungarian, Danish, and Dutch consumption data [22,[31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hungarian Consumers’ Exposure to Pesticide Residues Based on the Results of Pesticide Residue Monitoring between 2017 and 2021

Ambrus,

Szenczi-Cseh,

Bíró

et al. 2023

Agrochemicals

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The short-term intake (ESTI) of pesticide residues in Hungarian consumers was assessed based on 2331 test results obtained during the 2017–2021 monitoring program on frequently analyzed apples, sour cherries, table grapes, peaches, nectarines, peppers, and strawberries (23.5% of all samples taken from 119 crops). The age-specific consumption data were obtained from national food consumption surveys (2009 and 2018–2020). The exposure was characterized by Hazard Quotient and Hazard Index considering the acute reference doses of pesticide residues detected in the samples. When ESTI was calculated with all detected “single” residues and a variability factor of 3.6, recommended for evaluation of monitoring results, the HI only exceeded 1 for children <3 years old eating grapes (1.50–1.81). HI was <1 when any of the six foods were eaten together within one day. Between forty and fifty percent of samples contained 2–23 residues. Though the individual residue concentrations were below the corresponding MRLs, multiple residues being present in one sample resulted in maximum HI values in apples (1.14); grapes (6.57); peaches and nectarines (2.57); strawberries (2.74); and peppers (10.44). Residues with low ARfD values contributed the most. Applying HI is simple, but provides only point estimates; therefore, it should only be used in first-tier risk assessment.

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Risk assessment of the cumulative acute exposure of Hungarian population to organophosphorus pesticide residues with regard to consumers of plant based foods

Cited by 29 publications

References 7 publications

Pesticide Residues in Greenhouse Leafy Vegetables in Cold Seasons and Dietary Exposure Assessment for Consumers in Liaoning Province, Northeast China

Pesticide Residues in Greenhouse Leafy Vegetables in Cold Seasons and Dietary Exposure Assessment for Consumers in Liaoning Province, Northeast China

Novel Integrated Tiered Cumulative Risk Assessment of Heavy Metals in Food Homologous Traditional Chinese Medicine Based on a Real-Life-Exposure Scenario

Assessment of Hungarian Consumers’ Exposure to Pesticide Residues Based on the Results of Pesticide Residue Monitoring between 2017 and 2021

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