Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women

Solis-Coronado, Orlando; Villarreal-Vela, Mónica Patricia; Rodríguez-Gutiérrez, Hazyadee Frecia; González-Guerrero, Juan Francisco; Cerda‐Flores, Ricardo M.; Alcorta-Nuñez, Fernando; Camarillo-Cárdenas, Karen Paola; Pérez-Ibave, Diana Cristina; Vidal-Gutiérrez, Oscar; Ramírez-Correa, Genaro A.; Garza‐Rodríguez, María Lourdes

doi:10.3390/curroncol29020086

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…Li et al studied MMP7 -181A/G and documented significantly increased susceptibility to ovarian cancer (OR: 3.53) with -181G allele (A/G + G/G) compared to the A/A genotype. Our study also documented a similar increased risk for ovarian cancer, though OR was slightly less (1.82) in comparison to the study by Li et al [18].…”

Section: Association Of Mmp7 (-181a>g) Polymorphism With Susceptibili...supporting

confidence: 82%

“…Clinicodemographic details were obtained as per the questionnaire prepared and self-reported responses of the participants were recorded. Staging of ovarian carcinoma was done by using the International Federation of Gynecology and Obstetrics (FIGO) guidelines [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…Understanding the genetic determinants of ovarian cancer may prove helpful in predicting the aggressiveness and prognosis of the disease. There is only a limited number of studies regarding the role of MMP7 -181A>G (rs11568818) polymorphism in the development of ovarian cancer [ 18 ]. The published data based on an Indian study to show the association of the MMP7 promoter site SNP (181A>G) with the development of ovarian cancer is still lacking.…”

Section: Introductionmentioning

confidence: 99%

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Matrix Metalloproteinase-7 Promoter Site Single Nucleotide Polymorphism (-181A>G) in Epithelial Ovarian Cancer in the Eastern Indian Population

P.P.,

Kumari,

Dasmajumdar

et al. 2024

Cureus

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Background: Matrix metalloproteinase-7 (MMP7) plays multiple roles in different stages of tumor development. Elevated MMP7 activity has been reported in ovarian cancer. Single nucleotide polymorphism (SNP) of promoter sites of the MMP7 gene has been shown to cause alteration in gene expression, hence resulting in changes in susceptibility to various diseases and tumor development. Methods: The current study evaluated the association of epithelial ovarian cancer risk with MMP7 promoter site -181A>G polymorphism in the population of eastern India. The present case-control study included 64 histopathologically confirmed cases of epithelial ovarian cancer and 100 control subjects. The MMP7 -181A/G polymorphism was identified using polymerase chain reaction-restriction fragment length polymorphism. The association between genotypes and epithelial ovarian cancer risk was analyzed by odds ratio (OR) with a 95% confidence interval. Results: The frequencies of AA, AG, and GG genotypes in ovarian cancer cases were 37.5%, 46.9%, and 15.6%, respectively, while that of control subjects were 56%, 36%, and 8%, respectively, in the study population. By taking the wild-type AA genotype as a reference, it was found that genotype GG was associated with a significant risk for epithelial ovarian cancer (OR: 2.92). Frequency distribution of genotypes did not show any significant association with tumor characteristics like the International Federation of Gynecology and Obstetrics (FIGO) stage, histology, lymph node status, and distant metastasis. Conclusion: The present study demonstrated the association of MMP7 promoter site -181 GG genotype and the G allele with increased risk for epithelial ovarian cancer in the eastern Indian population.

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Section: Association Of Mmp7 (-181a>g) Polymorphism With Susceptibili...supporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Matrix Metalloproteinase-7 Promoter Site Single Nucleotide Polymorphism (-181A>G) in Epithelial Ovarian Cancer in the Eastern Indian Population

P.P.,

Kumari,

Dasmajumdar

et al. 2024

Cureus

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“…Some studies showed the rs3803662 C>T polymorphism is substantially associated with a higher likelihood of breast cancer (Q. Wang et al, 2016) (Solis-Coronado et al, 2022. The researchers supposed that TOX3 mutation is related to RM.…”

Section: Genetic Susceptibility To Recurrent Miscarriagementioning

confidence: 99%

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

Abd Ellatif,

Agwa,

Ashaat

et al. 2024

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Recurrent miscarriage (RM) is a severe pregnancy complication that results in the loss of two or more spontaneous pregnancies. RM has several complex reasons. Advances in genetics, immunology, and cell biology have strongly connected non-coding RNAs (ncRNAs) to recurrent miscarriages. NcRNAs regulate placental trophoblast cell processes, which affect trophoblast development, migration, and invagination; they also have a role in breast and ovarian cancer. As a result, their abnormal expression may contribute to the progression of RM. Several investigations have found a connection between RM and genetic polymorphisms that regulate cell migration. Variations in the long non-coding RNA (lncRNA) SOX2OT gene have been associated with a variety of cancer-related illnesses, particularly colorectal cancer, breast cancer, and cancer of the digestive tract. According to a recent study, the long non-coding SOX2OT rs9839776 CT raises the risk of RM. In this review, we explain the existing evidence supporting a relationship between the LncRNA SOX2OT rs9839776 polymorphisms and recurrent miscarriages.

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“…Two SNPs (rs4784227/rs3803662) located in the lncRNA cancer susceptibility 16 (CASC16) have been investigated in BC in different populations [18][19][20][21], indicating their possible association with BC risk. Based on our expression analysis, CASC16 is upregulated in tumor samples (logFC = 1.92) and is specifically upregulated in estrogen-positive subtypes.…”

Section: Selected Lncrna-snpsmentioning

confidence: 99%

LncRNA-SNPs in a Brazilian Breast Cancer Cohort: A Case-Control Study

Mathias

Marin

Kohler

et al. 2023

Genes

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Long noncoding RNAs (lncRNAs) are a class of non-coding RNAs that contain more than 200 nucleotides and exhibit a versatile regulatory capacity. Genomic alterations in lncRNAs have already been investigated in several complex diseases, including breast cancer (BC). BC is a highly heterogeneous disease and is the most prevalent cancer type among women worldwide. Single nucleotide polymorphisms (SNPs) in lncRNA regions appear to have an important role in BC susceptibility; however, little is known about lncRNA-SNPs in the Brazilian population. This study used Brazilian tumor samples to identify lncRNA-SNPs with a biological role in BC development. We applied a bioinformatic approach intersecting lncRNAs that are differentially expressed in BC tumor samples using The Cancer Genome Atlas (TCGA) cohort data and looked for lncRNAs with SNPs associated with BC in the Genome Wide Association Studies (GWAS) catalog. We highlight four lncRNA-SNPs—rs3803662, rs4415084, rs4784227, and rs7716600—which were genotyped in Brazilian BC samples in a case-control study. The SNPs rs4415084 and rs7716600 were associated with BC development at higher risk. These SNPs were also associated with progesterone status and lymph node status, respectively. The rs3803662/rs4784227 haplotype GT was associated with BC risk. These genomic alterations were also evaluated in light of the lncRNA’s secondary structure and gain/loss of miRNA binding sites to better understand its biological functions. We emphasize that our bioinformatics approach could find lncRNA-SNPs with a potential biological role in BC development and that lncRNA-SNPs should be more deeply investigated in a highly heterogeneous disease population.

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Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women

Cited by 4 publications

References 38 publications

Matrix Metalloproteinase-7 Promoter Site Single Nucleotide Polymorphism (-181A>G) in Epithelial Ovarian Cancer in the Eastern Indian Population

Matrix Metalloproteinase-7 Promoter Site Single Nucleotide Polymorphism (-181A>G) in Epithelial Ovarian Cancer in the Eastern Indian Population

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

LncRNA-SNPs in a Brazilian Breast Cancer Cohort: A Case-Control Study

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