Risk factor analysis for the development and progression of retinopathy of prematurity

Chang, Ji Woong

doi:10.1371/journal.pone.0219934

Cited by 82 publications

(82 citation statements)

References 37 publications

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“…Moreover, low gestational age (GA) and birth weight (BW) are the main drivers in the setting of prematurity 2 . Many other risk factors have been correlated to ROP worsening, such as persistent elevated oxygen saturation, bronchopulmonary dysplasia, sepsis, ventricular hemorrhage and genetic components 2 , 7 , 8 . Therefore, ROP can be defined as a multifactorial disorder, where prematurity does not represent the only explanatory driver.…”

Section: Introductionmentioning

confidence: 99%

Severe retinopathy of prematurity is associated with early post-natal low platelet count

Parrozzani

Nacci

Bini

et al. 2021

Sci Rep

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Pathophysiology of retinopathy of prematurity (ROP) still presents a gap. Lately blood tests parameters of premature infants have been measured at different times of ROP, attempting to detect correlations with ROP development and progression. So far, very early post-natal biomarkers, predictive of ROP outcome, have not been detected. Our purpose is to evaluate, in the earliest post birth blood sample, the correlation between routinely dosed blood parameters and ROP outcome. 563 preterm babies, screened according to ROP guidelines, were included and classified in conformity with ET-ROP study in “Group 1” (ROP needing treatment), “Group 2” (ROP spontaneously regressed) and “noROP” group (never developed ROP). The earliest (within an hour after delivery) blood test parameters routinely dosed in each preterm infant were collected. Platelet count was decreased in Group 1 versus noROP group (p = 0.0416) and in Group 2 versus noROP group (p = 0.1093). The difference of thrombocytopenic infants among groups was statistically significant (p = 0.0071). CRP was higher in noROP versus all ROPs (p = 0.0331). First post-natal blood sample revealed a significant thrombocytopenia in ROP needing treatment, suggesting a role of platelets in the pathophysiology and progression of ROP, possibly considering it as a predictive parameter of ROP evolution.

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Section: Introductionmentioning

confidence: 99%

Severe retinopathy of prematurity is associated with early post-natal low platelet count

Parrozzani

Nacci

Bini

et al. 2021

Sci Rep

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“…The duration of oxygen therapy and mechanical ventilation is an independent risk factor for ROP development. 31,32 In our study odds of developing ROP increases by 12% for every single day spent with oxygen therapy. But duration of mechanical ventilation is not statistically significant with development of ROP.…”

Section: Discussionmentioning

confidence: 49%

Incidence and risk factors for retinopathy of prematurity at a medical college hospital in rural Tamil Nadu, India

Elumalai¹,

Kathavarayan²,

Govindasamy³

2020

Int J Contemp Pediatr

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Background: The objective of the research was to evaluate the incidence of retinopathy of prematurity (ROP), association of prenatal and postnatal risk factors, pattern of ROP and treatment outcomes among infants admitted to neonatal intensive care unit (NICU) of tertiary care center located in Thiruvannamalai, Tamil Nadu.Methods: A retrospective study done in all infants admitted between April 2019 and March 2020 who met the criteria for ROP screening with gestational age (GA) less than or equal to 36 weeks or birth weight less than 2000 grams or with GA more than 36 weeks and birth weight more than 2000 gram with significant risk factors like intrauterine growth restriction, respiratory distress syndrome, sepsis, long term oxygen use, phototherapy, blood transfusion and maternal anemia. Treatment was offered to infants with stage 3 ROP and stage 2 in zone 2 with or without plus disease. Qualified infants were treated with argon laser photocoagulation within 72 hours of diagnosis. They were followed until the disease was successfully treated.Results: Out of total 3121 neonates, 717 neonates met the screening criteria. Incidence of ROP was found to be 33% (n=237). 46.4% (n=110) of ROP belongs to 32-36 weeks GA. 42.6% (n=101) of ROP belongs to 1500-2000 gm birth weight.Conclusions: Incidence of ROP is quite high in high risk neonates in our unit. Significant risk factors are long term oxygen use, blood transfusion and sepsis.

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“…Both bronchopulmonary dysplasia and the need for MV in the premature newborn ( 19 ) are closely related to ROP. Longer MV times are associated with greater risk of ROP requiring treatment ( 6 , 20 ). Recently, new oxygen therapy control measures have been implemented in neonatal intensive care units (NICUs) ( 21 ), as has early treatment by intravitreal bevacizumab or laser diode.…”

Section: Introductionmentioning

confidence: 99%

Risk Calculator for Retinopathy of Prematurity Requiring Treatment

et al. 2020

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Importance: Vascular delay that occurs early in the development of retinopathy of prematurity (ROP) is a risk factor that can be compensated by ensuring a good rate of retinal vascularization to avoid ROP that requires treatment. Background: The objective of the present study was to determine the association between ROP that requires treatment and risk factors such as the extent of the temporal avascular area of the retina and the number of days of mechanical ventilation (MV). Design: Observational retrospective case-control study. Participants: Two hundred and twenty-eight premature newborns included in the screening protocol for retinopathy of prematurity. Methods: Subjects underwent retinal examination in the 4 and 6th postnatal weeks. Main Outcome Measures : The temporal avascular area was measured in disc diameters (DD), while the MV time was measured in days of treatment. Results: Patients with a longer MV time had a higher risk of treatment (R 2 : 24.7, p < 0.0001; increase in risk of 8.1% for each additional day), as did those who showed greater avascular area (R 2 : 24.7, p < 0.0001; increase in risk of 111% for each additional DD). An online calculator system and a table are presented for calculating the risk of ROP requiring treatment as a function of these two risk factors. Conclusions and Relevance: The temporal avascular area of the retina and MV time must be taken into account in the first examination of the newborn to predict the need for ROP treatment.

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Risk factor analysis for the development and progression of retinopathy of prematurity

Cited by 82 publications

References 37 publications

Severe retinopathy of prematurity is associated with early post-natal low platelet count

Severe retinopathy of prematurity is associated with early post-natal low platelet count

Incidence and risk factors for retinopathy of prematurity at a medical college hospital in rural Tamil Nadu, India

Risk Calculator for Retinopathy of Prematurity Requiring Treatment

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