Risk factor of secretory immunoglobulin A and salivary lysozyme level in children aged under 3 years to severe early childhood caries

Primasari, Ameta; Octiara, Essie; Yanti, Nursantri

doi:10.1088/1755-1315/305/1/012001

Cited by 5 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of Primasari et al [ 41 ] and Al-ani et al [ 20 ] found that there was no difference in salivary s-IgA levels between caries-free people and caries patients, which was contradictory with the results of the present study. The results obtained by the above studies may be due to the small sample size and different criteria for judging dental caries.…”

Section: Discussioncontrasting

confidence: 99%

“…However, some studies have suggested that microorganisms can protect themselves from host immune attack by forming biofilms and reducing the expression of antigens [65, 66], which will cause higher levels of s-IgA in the saliva of healthy people than patients with caries. Dental caries was caused by the imbalance between enamel The results of Primasari's et al [41] and Al-ani's et al [20] found that there was no difference in salivary s-IgA levels between caries-free people and caries patients, which was contradictory with the results of this study. The results obtained by the above studies may be due to the small sample size and different criteria for judging dental caries.…”

Section: Discussioncontrasting

confidence: 94%

“…The results of the correlation between salivary s-IgA levels and the severity of dental caries were shown in Figure 5 . Because of the limited number of studies on differences in the severity of caries (only nine studies were included) [ 21 , 25 , 5 , 33 , 36 , 38 , 39 , 41 , 46 ], and the heterogeneity in the studies was greater than 50% ( I 2 >50%), a random-effects model was used ( P <0.001). The results show that when comparing the salivary s-IgA levels of patients with high dental caries and patients with low dental caries ( Figure 5 A), we found that the salivary s-IgA levels of patients with high dental caries were significantly lower than those of patients with low dental caries (SMD = −0.89, 95%CI: [−1.46; −0.31], P =0.003).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Gong

Wang

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

Objective: To determine the levels of s-IgA in saliva of caries patients and healthy controls, and to evaluate whether there is a correlation between it and caries by meta-analysis. Methods: The PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, Scopus, Chinese National Knowledge Infrastructure, Wanfang Data, Chongqing VIP database for Chinese Technical Periodicals, and China BioMedical Literature Services System databases were searched initially in April 2020 and repeated in August 2020. Two independent evaluators screened the literature and extracted the data according to the inclusion and exclusion criteria. R 4.0.2 software was used for meta-analysis. I2 test was commonly reflected the heterogeneity. Subgroup analysis and meta-regression analysis explore the sources of heterogeneity. Sensitivity analysis, funnel diagram, Begg’s rank correlation, and Egger’s linear regression were used to determine the possibility of publication bias. Results: The study was reviewed according to the project guidelines for optimal reporting (PRISMA) based on meta-analysis. A total of 30 case–control studies were included, with a total sample size of 1545 patients, including 918 caries patients and 627 healthy controls. Salivary s-IgA levels in caries patients were significantly lower than those in healthy controls (SMD = −0.49, 95%CI: [−0.94; −0.03], P=0.03). In addition, the results of subgroup analysis showed that the significant decrease of salivary s-IgA level was correlated with children patients, mixed dentition and Asian people (children: SMD = −0.45, 95%CI: [−0.89; −0.01], P=0.04; mixed dentition: SMD = −0.61, 95%CI: [−1.24; 0.03], P=0.06; Asian: SMD = −0.62, 95%CI: [−1.17; −0.08], P=0.02). The funnel diagram included in the study was symmetrically distributed, and the sensitivity analysis confirmed the robustness of the results. Conclusion: Salivary s-IgA levels in caries patients were significantly lower than in healthy controls. It has also been demonstrated that salivary s-IgA may be used as an alternative measure to identify subjects at risk of caries susceptibility, suggesting that salivary s-IgA may be a protective factor for dental caries.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Gong

Wang

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…Lysozyme, as a hydrolytic enzyme, breaks down cellular membranes gram-positive and gram-negative bacteria, fungi and viruses. It is one of the key antimicrobial factors of the oral fl uid [10]. Therefore, determination of the activity of this enzyme is informative concerning its eff ect on the state of local non-specifi c immunity, which is the fi rst-line protection against microbe-associated pathological processes.…”

Section: Introductionmentioning

confidence: 99%

Microbial Cariogenic Factors and the Mechanisms of Their Counteraction in the Oral Fluid of Children at Early Age

Godovanets,

Hrynkevych,

Khomyshyn

2024

Clin. and experim. pathol.

View full text Add to dashboard Cite

Objective – to determine the balance between pro- and antibacterial agents influencingupon the development of a carious process in children at an early age.Materials and methods. 117 children 2-3 years of age were examined. Two observationgroups were formed depending on the condition of the hard dental tissues. І groupincluded 52 children without caries, group II– 65 children with caries. The oral hygieneof the children from the observation groups was assessed by means of Kuzmina EM index.Lysozyme activity in the oral fluid was studied by means of bacteriological method. sIgАcontent was determined by means of radial immunodiffusion method. Streptococcusmutans concentration in the oral fluid of children was determined by means of «SalivaCheck Mutans» set. All the manipulations were carried out after an informed consent ofparents was obtained.Results. Oral hygiene in children during the period of the temporal occlusion formationis found to be unsatisfactory – (0,48±0,20) points according to Kuzmina EM index. Thelevel of colonization of the oral cavity with Streptococcus mutans is high in 34,48 %of stomatologically healthy children and in 73,33 % of children with caries. Underconditions of caries process development, the main protective components in the oralfluid change. In particular, sIgA level 17,14 % increases concerning the index of healthychildren (р<0,05), and lysozyme activity 1,25 times decreases respectively (р<0,05).Conclusions. All the children examined present soft dental plaque, which is confirmedby the values of hygienic indices and levels of Streptococcus mutans concentration,which is reliably higher in children from group II. Under conditions of caries processdevelopment, changes of the major protective components of the oral cavity appear. Theypromote effective action of cariogenic factors.

show abstract

“…2 Dental caries have a relationship with several factors, such as tooth condition, carbohydrate fermentation, and acid production from bacteria in the oral cavity. 3 It is caused by demineralization of the tooth, which is triggered by the production of organic acids by bacteria in dental plaque resulting from carbohydrate metabolism. 4,5 One strategy to prevent caries is to inhibit the demineralization process in the tooth through the use of minerals containing bioactive glass nano-silica, such as bagasse ash.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Yogurt and Probiotic Supplements Effects on the Hardness of Tooth Enamel: An In vitro Study

Primasari

Alfarizi²,

Minasari³

et al. 2022

Dentika Dental J.

View full text Add to dashboard Cite

The demineralization of tooth enamel, which can be triggered by acidic foods and drinks at pH < 5.5, can initiate dental caries. Yogurt and probiotic supplements are drinks that are often consumed to help digestive function and improve the immune system. However, both drinks have a low pH, thereby, a long time of consumption can trigger the demineralization process. This study aims to evaluate the enamel hardness after applying yogurt and probiotic supplements, which was carried out experimentally in a laboratory with a one-group post-test design. The sample used is 9 human maxillary premolars in each treatment group. The treatment group comprises the test material, such as yogurt and probiotic supplements, as well as one control group with artificial saliva. Dental samples were immersed in the test material for 96 hours, and the enamel hardness level was measured with a Micro Vickers Hardness tester. The T-paired test showed that soaking with yogurt does not significantly affect the hardness of the enamel, as indicated by a p-value of 0.016. However, the effect was significant in probiotic supplements, with p=0.004. The results showed that soaking with yogurt was not significantly different from probiotic supplements in reducing enamel hardness, as evidenced by the Post Hoc (LSD) test (p=0.464). Conclusively, yogurt decreased enamel hardness less than probiotic supplements.

show abstract

Risk factor of secretory immunoglobulin A and salivary lysozyme level in children aged under 3 years to severe early childhood caries

Cited by 5 publications

References 11 publications

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Microbial Cariogenic Factors and the Mechanisms of Their Counteraction in the Oral Fluid of Children at Early Age

A Comparison of Yogurt and Probiotic Supplements Effects on the Hardness of Tooth Enamel: An In vitro Study

Contact Info

Product

Resources

About