Risk factors affecting morbidity in typhoid enteric perforation

Abstract

If liquid electrolyte, blood, antibiotics, and parenteral nutrition are applied in typhoid enteric perforation cases adequately, then severe peritonitis becomes an independent risk factor that affects morbidity. Early diagnosis and appropriate surgery type would decrease morbidity and mortality.

Typhoid Intestinal Perforations: Has the Clinical Importance Decreased in Eastern Anatolia for 36 Years?

“…Despite the thoroughly described diagnostic and therapeutic strategies, the prognosis of TIPs is still grave with mean morbidity of 0.5%-78.6% [3,7,8] and mortality rates of 4.5%-75% [3,7,8,11,14], similar to that of our series. The presentation time, number and localization of the perforations, extensity of the abdominal contamination and the kind of the surgical operation are discussed as risk factors affecting morbidity [3,7] and mortality [3,7,8,[10][11][12][13][14] in TF.…”

“…TIP generally affects men in the second or third decades of the life during the second or third weeks of TF [2,3,6,7], as was found in our series. Although medical history, clinical findings, isolation of caused microorganism and serological tests are useful [1,3,6], and radiological techniques including plain abdominal radiography, ultrasonography and computed tomography [2,3,9] are helpful in the diagnosis of TIPs, operative findings associated with histological examination of the perforation edges are generally diagnostic tools [3].…”

“…TF is a global health problem, which is more often seen in developing countries, in which food, water and sanitation facilities are not sufficient [2,3,6,7]. TF remains a high incidence, particularly due to outbreaks in endemic areas, and it annually affects approximately 22 million cases in the world [2], while approximately 10,000 cases in Turkey [3], with a mean TIP rate of 0.8%-18% [4,5].…”

“…TF remains a high incidence, particularly due to outbreaks in endemic areas, and it annually affects approximately 22 million cases in the world [2], while approximately 10,000 cases in Turkey [3], with a mean TIP rate of 0.8%-18% [4,5]. Although south-eastern and eastern Anatolia are endemic TF regions in Turkey [3,7,8], it is evident in our results that there is a certain decrease in the incidence of TIPs for the last 36 years in our region, eastern Anatolia, probably due to early and effective antibiotic treatment in TF [3].…”

“…The presentation time, number and localization of the perforations, extensity of the abdominal contamination and the kind of the surgical operation are discussed as risk factors affecting morbidity [3,7] and mortality [3,7,8,[10][11][12][13][14] in TF.…”