Risk factors and comorbid conditions associated with lower urinary tract symptoms: EpiLUTS

Abstract

each LUTS subgroup were used to assess the data. RESULTSThe survey response rate was 59%. The final sample was 30 000 (men and women). The voiding + storage + postmicturition (VSPM) group reported the highest rates of comorbid conditions for both men and women, and the fewest were reported in the no/minimal LUTS and the postmicturitiononly groups. Increasing age was associated with increasing LUTS in men, but not in women. Comorbid conditions significantly associated with the VSPM group were arthritis, asthma, chronic anxiety, depression, diabetes (men only), heart disease, irritable bowel syndrome, neurological conditions, recurrent urinary tract infection, and sleep disorders. Risk factors, such as body mass index, exercise level and smoking, played less of a role, except for childhood nocturnal enuresis, which was significantly associated with most LUTS subgroups. CONCLUSIONIn this large population study, many comorbid conditions and risk factors were significantly associated with LUTS among both men and women. Further longitudinal investigations of the associations noted here would help physicians to understand the pathophysiology of LUTS and comorbid conditions, and provide clinical guidelines for patient management of comorbid conditions sharing common pathophysiological pathways. KEYWORDS LUTS, risk factors, comorbid conditions, prevalence, BPH OBJECTIVETo explore the risk factors and comorbid conditions associated with subgroups of lower urinary tract symptoms (LUTS) in men and women aged ≥ 40 years in three countries, using data from the EpiLUTS study, as LUTS are common amongst men and women and increase in prevalence with age.

1726 Are Commonly-Used Psychoactive Medications Associated With Lower Urinary Tract Symptoms?

“…This finding is consistent with many previous studies. [18][19][20][21][22][23] In our study, the association for depressive symptoms was stronger among men compared to women. While the reasons for this are unknown, the gender difference has also been observed in the BACH Survey for urinary incontinence [35] and in the large EPIC study for the symptoms of overactive bladder with incontinence.…”

“…We defined the presence of LUTS as a score of ≥8, corresponding to moderateto-severe symptoms. For graphical displays, LUTS severity categories were defined using the AUA-SI as follows: no symptoms (score=0), mild (1-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), severe (≥20). We also examined mean storage and voiding storage subscales of the AUA-SI.…”

“…[14,15] Possible pathways include promotion of cholinergic neuromuscular transmission in the detrusor muscle, as well as influence on autonomic function. [16,17] Furthermore, there is a largely consistent association of depression itself with urologic symptoms in multiple studies of cross-sectional [18][19][20][21] or longitudinal [22,23] design, making it difficult to sort out any underlying effect of depression from indicated medications. We previously found an association between depression and LUTS [24] in our population-based epidemiologic study.…”

Bladder ultrasonography for diagnosing detrusor overactivity: test accuracy study and economic evaluation

“…26 Episodes of urgency and sensation may also be recorded, along with the activities performed during or immediately preceding the involuntary loss of urine. Severity of incontinence in terms of leakage episodes and pad use may also be reported in bladder diaries.…”

Vaporization of the Prostate with 150-W Thulium Laser: Complications with 6-Month Follow-Up

“…It is estimated that approximately 35% of patients presenting with obstructive LUTS may report concomitant irritative symptoms. 21 Moreover, up to one-third of patients undergoing prostatectomy may present with urgency symptoms up to 11 months postsurgery. 22 Pereira-Correia and colleagues 13 described the appearance of urge urinary incontinence not associated with detrusor hyperactivity in 50% of patients who underwent VP with 120-W LBO, which remitted in the subsequent 3 to 12 months.…”