Risk Factors and Early Detection of Diabetes Mellitus in Early Rheumatoid Arthritis Women

Abstract

Background: Patients with rheumatoid arthritis show predominance of metabolic disorder characterized by overweight, central obesity, dyslipidemia, and impaired glucose tolerance, specifically, few studies have explained insulin resistance in this disease.Objective: The aim of the present study is to examine insulin resistance and the risk of developing diabetes mellitus in middle age Iraqi women with early rheumatoid arthritis.Patients and methods: This work involved seventy female with early rheumatoid arthritis. Who was attending to the National Diabetic Center (NDC) of Al-Mustansiriya University and 35 healthy subjects as a control group. From all subjects blood sample was drawn in fasting state to measure the biochemical parameters which including plasma glucose level and fasting insulin concentrations. Other measurements (RF and anti-CCP) were made by routine methods. Homeostasis model of assessment insulin resistance (HOMA-IR) by using the formula HOMA model Insulin sensitivity was calculated in RA patients and healthy control.Results: Results revealed a highly significant in the level of the rheumatoid factor (RF), anti-CCP and fasting insulin, and HOMA-IR when compared the patient group with the control group. While a significant increase in the level of FBG in the RA group than the control group. Also, there was a positive correlation with high significance among, Anti-CCP, and RF with HOMA-IR in the rheumatoid arthritis group. Conclusions: This study shows that patient with rheumatoid arthritis have abnormal insulin secretion with a high value of IR than a group of healthy control and these patients may be at risk of diabetic mellitus.

The Prevalence of Diabetes Mellitus Type 2 in Severe and Very Severe Chronic Obstructive Pulmonary Disease Patients

“…T2DM and COPD share a similar insidious onset, which usually leads to late presentation and diagnosis. Recognition of T2DM and/or COPD may be even more difficult in patients who already diagnosed with the other pathologies, particularly where they are consulted an organ-based specialist (6) . Patients with diabetes who experience chronic pulmonary damage (progressive and irreversible damage) due to diminished lung function and volumes, several functional abnormalities in the respiratory tract, pulmonary autonomic neuropathy, and decreased pulmonary diffusing capacity for carbon monoxide would simply exercise less, occasionally complain of dyspnea with exertion, and have annoyance-inducing seasonal upper respiratory symptoms.…”