Background: Patients with rheumatoid arthritis show predominance of metabolic disorder characterized by overweight, central obesity, dyslipidemia, and impaired glucose tolerance, specifically, few studies have explained insulin resistance in this disease.Objective: The aim of the present study is to examine insulin resistance and the risk of developing diabetes mellitus in middle age Iraqi women with early rheumatoid arthritis.Patients and methods: This work involved seventy female with early rheumatoid arthritis. Who was attending to the National Diabetic Center (NDC) of Al-Mustansiriya University and 35 healthy subjects as a control group. From all subjects blood sample was drawn in fasting state to measure the biochemical parameters which including plasma glucose level and fasting insulin concentrations. Other measurements (RF and anti-CCP) were made by routine methods. Homeostasis model of assessment insulin resistance (HOMA-IR) by using the formula HOMA model Insulin sensitivity was calculated in RA patients and healthy control.Results: Results revealed a highly significant in the level of the rheumatoid factor (RF), anti-CCP and fasting insulin, and HOMA-IR when compared the patient group with the control group. While a significant increase in the level of FBG in the RA group than the control group. Also, there was a positive correlation with high significance among, Anti-CCP, and RF with HOMA-IR in the rheumatoid arthritis group. Conclusions: This study shows that patient with rheumatoid arthritis have abnormal insulin secretion with a high value of IR than a group of healthy control and these patients may be at risk of diabetic mellitus.
This study aimed to measure the concentration of the elements: Cu, Zn, Pb, Cd, Fe and Mg, as well as the percentage of fat, ash, protein and moisture of ten sample of green tea that collected from Baghdad city markets. The results showed the highest value of ash and moisture (6.10, 4.55) in chamain, Dilmah, while lowest value (5.12, 3.21) in Lipton, Mahmood green tea respectively. Dilmah and Alghazalaen show the highest value of fat, protein (2.80, 15.03) respectively, the lowest percent of fat and protein was abserved in Mahmood, Alwazah green tea, respectively. The levels of elements in this study were investigated by using atomic absorption spectrophotometry. All elements concentration was below the permissible limits of the Iraqi standard specifications for tea.
Background: Patients with rheumatoid arthritis show predominance of metabolic disorder characterized by overweight, central obesity, dyslipidemia, and impaired glucose tolerance, specifically, few studies have explained insulin resistance in this disease.Objective: The aim of the present study is to examine insulin resistance and the risk of developing diabetes mellitus in middle age Iraqi women with early rheumatoid arthritis.Patients and methods: This work involved seventy female with early rheumatoid arthritis. Who was attending to the National Diabetic Center (NDC) of Al-Mustansiriya University and 35 healthy subjects as a control group. From all subjects blood sample was drawn in fasting state to measure the biochemical parameters which including plasma glucose level and fasting insulin concentrations. Other measurements (RF and anti-CCP) were made by routine methods. Homeostasis model of assessment insulin resistance (HOMA-IR) by using the formula HOMA model Insulin sensitivity was calculated in RA patients and healthy control.Results: Results revealed a highly significant in the level of the rheumatoid factor (RF), anti-CCP and fasting insulin, and HOMA-IR when compared the patient group with the control group. While a significant increase in the level of FBG in the RA group than the control group. Also, there was a positive correlation with high significance among, Anti-CCP, and RF with HOMA-IR in the rheumatoid arthritis group. Conclusions: This study shows that patient with rheumatoid arthritis have abnormal insulin secretion with a high value of IR than a group of healthy control and these patients may be at risk of diabetic mellitus. عوامل الخطر والتشخيص المبكر لداء السكري للنساء حديثات الاصابة بألتهاب المفاصل الروماتويدي محمد حسن علي د.عـبير جبـار حسن أيناس جبار حسن الخلاصة: خلفية البحث:يكون المرضى الذين يعانون من التهاب المفاصل الروماتويدي عرضة للاصابة بمتلازمة التمثيل بالغذائي والعوامل المرتبطة بها مثل زيادة الوزن، وقلة دهون الدم أو ضعف تحمل الجلوكوز، وهناك بعض الدراسات بينت ان هولاء المرضى يكونون معرضون لمقاومة الانسولين . الهدف: صممت هذه الدراسة لفحص مقاومة الانسولين وخطر الإصابة بداء السكري عند النساء العراقيات المصابات حديثا بالتهاب المفاصل الروماتويدي. طرق العمل: شملت الدراسة سبعين أنثى مصابات حديثا بالتهاب المفاصل الروماتويدي و 35 من النساء المتطوعات كمجموعة ضابطة. تم سحب عينة الدم من الجميع في حالة الصيام لقياس المعلمات البيوكيميائية بما في ذلك مستوى الجلوكوز ، تركيزالأنسولين وقياسات أخرى مثل (RF and anti-CCP). وايضا تم حساب المقاومة للانسولين (HOMA-IR). النتائج أظهرت النتائج وجود زيادة معنوية في مستوى العامل الروماتويدي (RF) وتركيز الانسولين مقاومة الانسولين (HOMA-IR) عند مقارنة مجموعة المرضى مع مجموعة السيطرة. في حين أن زيادة كبيرة في مستوى السكر الصائم في مجموعة المرضى مقارنة بالمجموعة الضابطة. أيضا كان هناك علاقة إيجابية مؤثرة بين، Anti-CCP, and RF و HOMA-IR في مجموعة مرضى التهاب المفاصل الروماتويدي. الاستنتاجات: اظهرت نتائج هذه الدراسة أن المرضى بالتهاب المفاصل الروماتويدي يكون لديهم إفراز الأنسولين غير طبيعي وبالتالي تظهر لديهم مقاومة للانسولين ويكونون عرضة لخطر الاصابة بمرض السكري. الكلمات المفتاحية: مقاومة الانسولين, داء السكري, التهاب المفاصل الروماتويدي.
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