Risk factors and prediction model for nonalcoholic fatty liver disease in northwest China

Abstract

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most important chronic liver disease worldwide. The prevalence of NAFLD in China has also increased year by year. This study aimed to detect NAFLD early by developing a nomogram model in Chinese individuals. A total of 8861 subjects who underwent physical examination in Karamay and were 18 to 62 years old were enrolled. Clinical information, laboratory results and ultrasound findings were retrieved. The participants were randomly assigned to the development set (n = 6203) and the validation set (n = 2658). Significant variables independently associated with NAFLD were identified by least absolute shrinkage and selection operator (LASSO) regression and the multiple logistic regression model. Six variables were selected to construct the nomogram: age, sex, waist circumference (WC), body mass index (BMI), alanine aminotransferase (ALT), triglycerides and glucose index (TyG). The area under the receiver operating characteristic curve (AUROC) of the development set and validation set was 0.886 and 0.894, respectively. The calibration curves showed excellent accuracy of the nomogram model. This physical examination and laboratory test-based nomogram can predict the risk of NAFLD intuitively and individually.

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

“…In contrast to some previous observational studies, our study results suggest that BMI is not a direct factor leading to NAFLD. This discrepancy may be attributed to the smaller sample sizes and uncontrolled potential variables in those studies ( 48 , 49 ). The research findings of Yuan et al corroborate our conclusion that type 2 diabetes might be a key mediator in the pathway from BMI to NAFLD ( 50 ).…”

Gastrointestinal and Hepatological Manifestations in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results from the Major COVID Hospital in Serbia

“…Regarding liver biochemistry, mild elevation of AST was present in 90% of patients, while mild elevation of ALT was observed in over 95% of patients. Men over 45 years of age had elevated liver enzymes more often, as did the population over 65 years of age, which can be explained by the fact that metabolic liver diseases are more common in men, as well as polypharmacy in patients over 65 years old [ 24 ]. Liver enzymes were frequently elevated in patients with COVID-19 pneumonia in over 60% of cases.…”

Dietary patterns and metabolic dysfunction-associated fatty liver disease in China’s multi-ethnic regions

“…The reason why the prevalence was low in this population may as follows. Many risk factors have been identified in previous study [ 28 , 29 ], which including age, obesity, genetic background, socioeconomic status, complications and lifestyle such as diet and physical activity. It has been well recognized that obesity is a vital contributor to MAFLD, several researches have studied the relationship between obesity and MAFLD [ 30 , 31 ], and most studies concluded that obesity was positively associated with MAFLD.…”