Risk Factors and Risk Assessment

Goldstein, Nancy S.; Ziegfeld, Constance R.

doi:10.1016/b978-1-4160-4932-6.50009-3

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…Breast cancer is one of the most common diseases in women globally [1] . Several factors make women at high risk of the breast cancer [2] . Early detection and the use of radiation therapy, surgery, and chemotherapeutic drugs including selective estrogen receptor modulators (SERMs) and aromatase inhibitors can reduce invasive breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Prediction of anticancer peptides against MCF-7 breast cancer cells from the peptidomes of Achatina fulica mucus fractions

E-kobon

Thongararm

Roytrakul

et al. 2016

Computational and Structural Biotechnology Journal

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Several reports have shown antimicrobial and anticancer activities of mucous glycoproteins extracted from the giant African snail Achatina fulica. Anticancer properties of the snail mucous peptides remain incompletely revealed. The aim of this study was to predict anticancer peptides from A. fulica mucus. Two of HPLC-separated mucous fractions (F2 and F5) showed in vitro cytotoxicity against the breast cancer cell line (MCF-7) and normal epithelium cell line (Vero). According to the mass spectrometric analysis, 404 and 424 peptides from the F2 and F5 fractions were identified. Our comprehensive bioinformatics workflow predicted 16 putative cationic and amphipathic anticancer peptides with diverse structures from these two peptidome data. These peptides would be promising molecules for new anti-breast cancer drug development.

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Section: Introductionmentioning

confidence: 99%

Prediction of anticancer peptides against MCF-7 breast cancer cells from the peptidomes of Achatina fulica mucus fractions

E-kobon

Thongararm

Roytrakul

et al. 2016

Computational and Structural Biotechnology Journal

View full text Add to dashboard Cite

show abstract

“…The first problem is particularly important in young women, in whom the role of ultrasound – as the authors noted – cannot be overestimated due to the structure of the breasts. For example, a 20-year-old female patient presents with a lump in the breast, for an ultrasound test, and does not expect to receive a diagnosis by biopsy; therefore a senologist-ultrasonographer is faced with the dilemma whether to classify the condition as BI-RADS 3 or BI-RADS 4, considering that the risk of developing breast cancer within 10 years from the age of 20 is 1:1760 (0.06%) ( 5 ) . The second issue concerns the nature of counselling offered to the patient, because if the US permits identification of the gene expression patterns of different molecular subtypes of BC, the patient must be informed of the specific diagnosis and associated course of treatment before undergoing biopsy and receiving the associated histopathological result.…”

mentioning

confidence: 99%