Risk factors and risk for mortality of mild hypoparathyroidism in hemodialysis patients

Guh, Jinn‐Yuh; Chen, Hung‐Chun; Chuang, Hung‐Yi; Huang, Su-Chen; Chien, Li‐Chu; Lai, Yung‐Hsiung

doi:10.1053/ajkd.2002.33398

Cited by 70 publications

(66 citation statements)

References 43 publications

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“…13,16,17 Reduced intake of calcium, phosphorous and bPEP/bET predicts mortality in hemodialysis S-C Chen et al protein might lead to low serum creatinine and PTH levels, which usually reflect poor nutritional status and might contribute to high mortality. 13,18 In this study, patients in the mortality group had lower creatinine and PTH levels and their serum creatinine level was a predictor of overall and cardiovascular mortality (HR, 0.733; P¼0.029 and HR, 0.610; P¼0.004, respectively) in multivariate analysis. Therefore, malnutrition, as indicated by the low serum creatinine and PTH levels, might have a function in increased mortality in this study.…”

Section: Discussionmentioning

confidence: 60%

A new systolic parameter defined as the ratio of brachial pre-ejection period to brachial ejection time predicts overall and cardiovascular mortality in hemodialysis patients

et al. 2010

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Impaired left ventricular systolic function is an important cause of mortality in hemodialysis patients. An increase in the ratio of pre-ejection period (PEP) to ejection time (ET) is associated with a decrease in left ventricular systolic function. Brachial PEP (bPEP) and brachial ET (bET) can be automatically determined from an ankle-brachial index (ABI)-form device. The aim of this study was to investigate whether bPEP/bET was a useful predictor for overall and cardiovascular mortality in hemodialysis patients. We enrolled 212 hemodialysis patients in one regional hospital. The bPEP and bET were measured using an ABI-form device. The mean follow-up period was 28.3 ± 5.7 months. The relative mortality risk was analyzed by Cox-regression methods. Twenty-two deaths were recorded in 212 patients (10.4%). In a multivariate analysis, the bPEP/bET (hazard ratio [HR], 1.055; P¼0.047) and serum creatinine level (P¼0.029) were positively and negatively associated with overall mortality, respectively. In addition, increased bPEP/bET (HR, 1.080; P¼0.017), increased fasting glucose (P¼0.046) and decreased serum creatinine level (P¼0.004) were independent predictors for cardiovascular mortality. Our findings show that bPEP/bET, a surrogate of left ventricular systolic function, is a useful predictor for overall and cardiovascular mortality in hemodialysis patients. Screening hemodialysis patients by means of bPEP/bET may help to identify a high-risk group for increased mortality.

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Section: Discussionmentioning

confidence: 60%

A new systolic parameter defined as the ratio of brachial pre-ejection period to brachial ejection time predicts overall and cardiovascular mortality in hemodialysis patients

et al. 2010

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“…In addition, increased mortality was linked with higher PTH levels, particularly in the highest PTH categories (5-7). Some studies have also demonstrated increased mortality with low PTH levels (22,23) and low Ca levels (10), suggesting that these relationships may be complex. A time-dependent survival analysis reported that P and Ca ϫ P levels above the upper thresholds published by KDOQI were associated with increased all-cause mortality in hemodialysis and peritoneal dialysis patients (10).…”

Section: Discussionmentioning

confidence: 99%

Consistent Control of Mineral and Bone Disorder in Incident Hemodialysis Patients

Danese¹,

Belozeroff²,

Smirnakis³

et al. 2008

Clinical Journal of the American Society of Nephrology

134

104

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Results: In the simultaneous control analysis, patients who achieved target for none of the markers had a 51% greater risk for death than those who achieved target for all three markers (reference group). Patients who achieved any target for any single marker had a 35 to 39% higher risk for death, and patients who achieved target for any two of the three markers had a 15 to 21% higher risk for death compared with the reference group. In the time in target analysis, patients with parathyroid hormone in target for 4 quarters had a 25% lower risk for death compared with those who did so for <1 quarter (reference group). Patients with calcium in target for 4 quarters had a 14% lower risk, and patients with phosphorus in target for 4 quarters had a 38% lower risk.Conclusions: Consistent control of the markers of bone metabolism and disease within published targets is a strong predictor of survival in hemodialysis patients.

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“…CKD-MBD has two distinct components; high PTH related to high bone turn over and low PTH resulting in adynamic bone disease. 14 Diabetic patients 17 and those with poor glycaemic control 9,12,13 are reported to have low iPTH and at high risk of vascular calcification 18 , accelerated peripheral vascular disease 19 and adverse cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Serum Intact Parathyroid Hormone Level is Inversely Correlated with Glycated Haemoglobin in Diabetic Chronic Kidney Disease Stages 3-5 Predialysis Patients

et al. 2017

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Introduction: Diabetes mellitus (DM) is one of the leading causes of chronic kidney disease (CKD). Management of chronic kidney disease-mineral and bone disorder (CKD-MBD 77±2.14, 6.8±3.0, 141.1±75.7, 8.1±1.2, 5.2±1.9,164.1±135.3 and 229.7±151.2 respectively. Mean HbAlc (%) and iPTH (pg/ml) in CKD stages 3, 4 and 5 were 8.36±1.59 and 171.7±127.9, 7.99±1.92 and 179.5±131.4, and 7.77±2.14 and 273.8±119.2

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Risk factors and risk for mortality of mild hypoparathyroidism in hemodialysis patients

Cited by 70 publications

References 43 publications

A new systolic parameter defined as the ratio of brachial pre-ejection period to brachial ejection time predicts overall and cardiovascular mortality in hemodialysis patients

A new systolic parameter defined as the ratio of brachial pre-ejection period to brachial ejection time predicts overall and cardiovascular mortality in hemodialysis patients

Consistent Control of Mineral and Bone Disorder in Incident Hemodialysis Patients

Serum Intact Parathyroid Hormone Level is Inversely Correlated with Glycated Haemoglobin in Diabetic Chronic Kidney Disease Stages 3-5 Predialysis Patients

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