Risk factors associated with a breast cancer in a population of Moroccan women whose age is less than 40 years: a case control study

Laamırı, Fatima Zahra; Hasswane, Nadia; Kerbach, Aicha; Ashayeri, Hassan; Taboz, Youness; Benkirane, Hassna; Mrabet, M.; Barkat, Amina

doi:10.11604/pamj.2016.24.19.8784

Cited by 15 publications

(19 citation statements)

References 26 publications

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“…In this study, the results showed that more respondents in the experimental group used some form of contraception, while in the 2002 study ( 12 ) there was no significant difference between the control (3.6%) and the experimental group (2.4%) and similar results are quoted by Laamiri et al ( 17 ).…”

Section: Discussionsupporting

confidence: 80%

Predictive Analysis of Palmar Dermatoglyphics in Patients with Breast Cancer for Small Bosnian-Herzegovinian Population

et al. 2018

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Introduction:Malignant breast cancer is the most common malignancy in women between 40 and 55 years of age. Dermatoglyphs are polygenetically determined properties, whose appearance and number are determined by a specific gene. They represent the skin reefs that are created by epidermis on the fingers or toes, palms and soles. Palmar dermatoglyphs have been used to estimate the hereditary basis of many diseases.Aim:The aim of the paper is to determine whether there is a statistically significant difference between the observed qualitative and quantitative parameters of both palms between the experimental and the control group.Material and Methods:A survey of the qualitative and quantitative properties of the palmar complex was carried out on a total of 100 female respondents. The first group included 50 women with breast cancer. Comparative data were used for the analysis of palmar dermatoglyphs in the second group of respondents, or 50 phenotypic healthy female subjects. The imprints of the palmar complex were taken using the printake ribbons, analyzed, and the data was then statistically processed and displayed in charts. An analysis of the number of reefs between two digital triradius was performed, followed by the determination of the axially triad position, as well as the ATD angle measurement.Results:Quantitative analysis of ATD-angle showed statistically significant difference between the left and right palms of the analyzed groups. However, the analysis of the number of reefs between triradius A-B, B-C, C-D did not show statistically significant results for both the left and right hand between the analyzed groups.Conclusion:These results indicate that the quantitative palmar parameter, ATD-angle, can play a role in identifying women with increased risk of breast cancer.

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Section: Discussionsupporting

confidence: 80%

Predictive Analysis of Palmar Dermatoglyphics in Patients with Breast Cancer for Small Bosnian-Herzegovinian Population

et al. 2018

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“…Late menopause is associated with the risk of ductal types and lobular types of breast malignancies as well as HR+ histological type breast cancers in well-differentiated (G1) forms. 3 Menarche and menopause bring marked changes within the breast and are related to hormonal fluctuations and cellular proliferation. 16 Age at Menopause Before menopause, serum ovarian hormones circulate freely in the blood and have bioavailability to the breast, resulting in the proliferation of breast epithelial cells.…”

Section: Her2 Breast Cancermentioning

confidence: 99%

“…In univariate analysis, it was found that multiparous state decreases the risk of breast malignancies up to 74.2%. 3 Higher parity is associated with extensive breast cancer mortality among premenopausal women. A large UK cohort study found that approximately a 10% reduction in risk for each additional birth for the most common histologic types of breast malignancies is seen.…”

Section: Her2 Breast Cancermentioning

confidence: 99%

“…30 Other studies have stated that the blood ER levels of nursing women gradually increase after the last birth and continue to increase for several years until they reach the nulliparous state. 3 A study in 2002 analyzed the role of reproductive factors in breast cancer occurrence. It was agreed that the protective effect of breastfeeding is directly proportional to the duration of breastfeeding a mother has.…”

Section: Prolonged Interval Between Menarche and First Pregnancymentioning

confidence: 99%

“…Hence, it constitutes a major public health concern in both developed and developing countries as a female cancer risk. 3 Over the past decade, it has been evident that breast cancer represents as a heterogeneous disease, for which different subtypes are distinguished based on the combination of tumor grade and presence of hormone receptors, i.e. estrogen (ER), progesterone (PR), and human epidermal growth factor receptor-2 (HER2).…”

Section: Introductionmentioning

confidence: 99%

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Reproductive Factors and Breast Cancer Risk

Tarannum¹,

Pittala²,

Deekshitha³

et al. 2019

Int J Med Rev

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A neoplasm, also referred to as a tumor, is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissue and remains in the same excessive manner even after removal of the stimuli which evoked the changes. Tumors may be either benign or malignant. Benign tumors remain localized and are amenable to surgical removal, whereas malignant tumors, i.e. cancerous ones, adhere to any part in an obstinate manner, often invade surrounding tissue, and metastasize to distinct sites. Breast cancer occupies second place as the most occurring cancer in terms of incidence. Breast cancer is a heterogenous cancer, mostly linked with reproductive and hormonal factors in its occurrence. Nulliparous, younger age at menarche, early age pregnancy, older age at first live birth, late menopause, prolonged interval between menarche and first pregnancy, repeated abortions, first pregnancy after 35 years, and no/less breastfeeding are major risk factors for breast malignancies. Recent studies have shown that the implications of reproductive and hormonal factors in patients with breast cancer are associated mostly with BRCA1 (breast cancer gene 1) and BRCA2 (breast cancer gene 2) gene mutations.

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Glutathione S transferase T1 gene polymorphism and its promoter methylation are associated with breast cancer susceptibility in Egyptian women

Raafat

Ismail

Hawsawi

et al. 2021

Biotech and App Biochem

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Background Breast cancer (BC) is one of the leading causes of cancer mortality in women. Glutathione S‐transferase (GSTT1) is involved in activation of detoxification reactions and catalysis of chemicals conjugation with glutathione. GSTT1 genotype is a limiting factor for some environmental diseases. Epigenetic changes have an essential role in BC through inappropriate interaction between genomic and environmental risk factors. Aim This study was directed to explore the association of BC risk with GSTT1 genetic variations and its methylation status in Egyptian women. Design and Methods This study included 100 healthy women as the control group and 100 patients were clinically and histologically diagnosed with breast cancer. All blood samples were used for genomic DNA extraction. GSTT1 genotyping was accomplished by multiplex PCR and methylation‐specific PCR was used to analyze the GSTT1 promoter methylation status. Results Breast cancer patients showed significant incidence of null GSTT1 in relation to controls (p = 0.004). GSTT1 gene promoter methylation status showed significant difference between hypermethylated and unmethylated patients when compared with healthy subjects (p = 0.005). GSTT1 promoter methylation status was not significantly associated with null genotype. There was no significant association between GSTT1‐null genotypes and BC stage in cases with or without family history, but for promotor methylation, there was significant association with stage III and IV breast cancer disease. Conclusion GSTT1 null genetic variant and promoter hypermethylation in the GSTT region of the gene may be considered as critical risk factors for BC in Egyptian women.

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Risk factors associated with a breast cancer in a population of Moroccan women whose age is less than 40 years: a case control study

Cited by 15 publications

References 26 publications

Predictive Analysis of Palmar Dermatoglyphics in Patients with Breast Cancer for Small Bosnian-Herzegovinian Population

Predictive Analysis of Palmar Dermatoglyphics in Patients with Breast Cancer for Small Bosnian-Herzegovinian Population

Reproductive Factors and Breast Cancer Risk

Glutathione S transferase T1 gene polymorphism and its promoter methylation are associated with breast cancer susceptibility in Egyptian women

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