Risk factors associated with COVID-19-induced death in patients hospitalized in intensive care units (ICUs) in a city in Southern Brazil

Olak, André Silva; Susuki, Aline M; Kanashiro, Milena; Paoliello, Mônica Maria Bastos; Aschner, Michael; Urbano, Mariana Ragassi

doi:10.1016/j.toxrep.2021.07.020

Cited by 4 publications

(1 citation statement)

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“…In contrast, in the study by Grasselli et al [ 19 ], the independent risk factors associated with mortality include male gender, advanced age, history of chronic obstructive pulmonary disease (COPD), and high fraction of the oxygen inspiration level. In addition, immunosuppression, cardiovascular disease, diabetes, neurological disorders, renal disease [ 8 , 33 ], and the use of invasive mechanical ventilation [ 17 ] can be highlighted.…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic Profile and Risk Factors for the Evolution of Patients with COVID‐19 in ICUs in Brazil: A Cross‐Sectional Study

Fernandes Lira,

Alves de Olinda,

Correia Basto da Silva

et al. 2024

The Scientific World Journal

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This is a cross‐sectional study, with secondary data from Brazilian hospitals in the state of Paraíba, between January 2021 and January 2022. The evolution of clinical cases configured the dependent variable (cure or death), while the predictive variables were sociodemographic data, risk factors, use of ventilatory support, and vaccination against COVID‐19. With the help of R software, the following tests were used: chi‐square, Pearson’s chi‐square, and Fisher’s exact adherence. Simple logistic regression models were constructed, and odds ratios (95% CI) were estimated using the LR test and Wald test. 7373 cases were reported, with a mean age of 58.1. Of the reported cases, 63.8% died. The most frequent sociodemographic profile included male people, of mixed race, with less than eight years of schooling. Chronic cardiovascular disease (OR 1.28; 95% CI: 1.13–1.45), diabetes (OR 1.41; 95% CI: 1.24–1.61), lung disease (OR 1.52; 95% CI: 1.11–2.09), and the use of invasive ventilatory support (OR 14.1; 95% CI: 10.56–18.59) were all associated with increased mortality. Nonvaccination was associated with a decreased risk of death (OR 0.74; 95% CI: 0.65–0.84). Male patients, nonwhite, and those with low education were more likely to have a worse clinical outcome. The risk factors studied were related to deaths, and those who did not require ventilatory support were related to cure.

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