Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases

Nunes, Kamilla Schmitz; Matos, Leandro Luongo de; Cavalheiro, Beatriz G.; Magnabosco, Felipe Ferraz; Tavares, Marcos Roberto; Kulcsar, Marco Aurélio Vamondes; Hoff, Ana O.; Kowalski, Luiz Paulo; Leite, Ana Kober Nogueira

doi:10.1007/s12020-021-02901-z

Cited by 11 publications

(3 citation statements)

References 33 publications

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“… 33 , 34 With the current high recurrence rate of thyroid cancer, our research results may help reduce recurrence and improve post-surgery prognosis. 35 In later stages, monitoring the survival of patients with distant metastases after treatment can further refine patient management guidelines. 36 …”

Section: Discussionmentioning

confidence: 99%

Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Fan,

Zhang,

Wang

et al. 2024

DIGITAL HEALTH

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Purpose This study aims to evaluate the diagnostic value of texture analysis for lymph node metastasis after thyroid cancer surgery. Methods We retrospectively analyzed patients who underwent positron emission tomography/computed tomography (PET/CT) examination before 131I treatment at Shanghai Tenth People's Hospital between 2017 and 2020. Clinical follow-up results were used as the criterion for determining the presence of lymph node metastasis. The study included 119 patients, who were then randomly divided into training and test groups in a 7:3 ratio. Regions of interest were identified, and radiomics features were extracted using LIFEx 7.3.0. Mann–Whitney U test and LASSO regression were employed to screen radiomics parameters for modeling. Subsequently, a nomogram model was built by combining radscore and clinical features. SPSS 26.0 software was utilized for statistical analysis, and p < 0.05 was considered statistically significant. Results Follow-up confirmed 54 patients with thyroid cancer lymph node metastasis and 65 patients in the non-metastasis group. A total of 119 lymph nodes were delineated. For each lesion, 164 CT texture features and 164 PET texture features were extracted, and 107 significant parameters were identified, including 16 CT texture parameters and 91 PET texture parameters. After screening, 3 CT parameters, 4 PET parameters and 12 PET/CT parameters were selected to establish three radiomic models. The AUC values were as follows: AUC (CT) = 0.730, AUC (PET) = 0.759 and AUC (PET/CT) = 0.864. We then combined clinical features and radscore to construct a nomogram, resulting in a C-index of 0.915 in the training group. In the test group, the C-index was confirmed to be 0.868. Conclusions Radiomics may enhance the diagnostic efficiency of lymph node metastases after thyroid cancer surgery and could potentially assist clinicians in future diagnoses. The developed nomogram, which combines radiomics and clinical features, offers relatively high accuracy in helping clinicians assess the risk of metastasis in thyroid patients after surgery.

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Section: Discussionmentioning

confidence: 99%

Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Fan,

Zhang,

Wang

et al. 2024

DIGITAL HEALTH

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“…Differentiated thyroid cancer (DTC) is the most common histological and least-aggressive type of thyroid cancer ( 1 ). However, 10%–20% of DTC patients develop distant metastatic disease, which is the most frequent cause of disease-specific death ( 2 , 3 ). Distant metastatic DTC (dmDTC) patients require radioiodine (RAI) therapy at least once during their disease course.…”

Section: Introductionmentioning

confidence: 99%

Indoleamine 2,3-Dioxygenase Immune Status as a Potential Biomarker of Radioiodine Efficacy for Advanced Distant Metastatic Differentiated Thyroid Cancer

et al. 2022

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PurposeHost immunity influences the impact of cancer therapy but the effect of immune status in radioiodine (RAI)-treated differentiated thyroid cancer (DTC) remains obscure. Here we investigated indoleamine 2,3-dioxygenase (IDO) activity as a biomarker of response to RAI in patients with distant metastatic DTC (dmDTC).MethodsPatients with dmDTC receiving RAI were evaluated for serum IDO activity (kynurenine and kynurenine:tryptophan ratio) at baseline and 3 months after RAI. The optimal cut-off value for these biomarkers to predict response was established by receiver operating characteristic analysis. The relationship between disease outcomes, overall survival (OS) and progression-free survival (PFS), and IDO activity levels was studied.ResultsHigher baseline kynurenine:tryptophan ratio (>2.46) was correlated with poorer RAI response as well as shorter median PFS (45 mo versus not reached, p=0.002) and OS (78 mo versus not reached, p=0.035). High baseline kynurenine:tryptophan ratio was also correlated with a reduced number of tumor-infiltrating lymphocytes. Higher post/pre-kynurenine ratio (>1.69) was associated with survival endpoints: shorter median PFS (48 mo versus not reached, p=0.002) and OS (68 mo versus not reached, p=0.010). Favorable baseline and favorable change corresponded with better PFS and OS.ConclusionsOur results suggest that RAI also alters IDO activity in dmDTC patients. IDO activity could predict progression and survival outcomes for advanced dmDTC patients. Serum IDO biomarker levels could be used to select dmDTC likely to benefit from RAI therapy, although further studies are necessary.

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“…For example, patients with poor cardiopulmonary function eventually died of heart failure rather than thyroid cancer, which would lead to an underestimate of the efficacy of 125 I on the prognosis of the patient. Therefore, we suggest that the authors should focus on patients’ disease-specific mortality rather than OS ( 2 ).…”

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confidence: 99%

A commentary on 125I seed brachytherapy for refractory loco-regional recurrence of non-anaplastic thyroid cancer

Wang

Xia

2022

Front. Oncol.

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Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases

Cited by 11 publications

References 33 publications

Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Indoleamine 2,3-Dioxygenase Immune Status as a Potential Biomarker of Radioiodine Efficacy for Advanced Distant Metastatic Differentiated Thyroid Cancer

A commentary on 125I seed brachytherapy for refractory loco-regional recurrence of non-anaplastic thyroid cancer

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