Risk factors associated with gallstone and biliary sludge formation during pregnancy

Bolukbas, Fusun F.; Bolukbas, Cengiz; Horoz, Mehmet; İnce, Ali Tüzün; Uzunköy, Ali; Ozturk, Adil; Aka, Nurettin; Demirci, Fuat; İnci, Erdal; Ovunc, Oya

doi:10.1111/j.1440-1746.2006.04444.x

Cited by 44 publications

(21 citation statements)

References 34 publications

(66 reference statements)

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“…There are several reports from Turkey on the etiological factors of gallstone formation. Pregnancy (12), iron deficiency anemia (13) and bacterial infections such as H. pylori were suggested to have possible roles in the formation of gallstones (14). Okumuçoglu et al (15) reported in their series that cholesterol stones are almost three times as frequent as other types of stones and concluded that this might be related to the dietary habits of Turkish people.…”

Section: Discussionmentioning

confidence: 99%

Expression of p16 protein and cyclin d1 in periampullary carcinomas

Tuncer

Türk²,

Arici³

et al. 2011

TJPATH

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Objective: Gallbladder is one of the most commonly encountered specimen in a pathology laboratory. a diverse spectrum of diseases affect the biliary system, often presenting with similar clinical signs and symptoms. We aimed to define the profile of gallbladder diseases in our region, and to determine potential correlations between histopathologic features we observed. Material and Method: We reviewed all cholecystectomies processed in Department of Pathology of afyon Kocatepe University Hospital between January 2000 and March 2008. Gross and histopathologic features of the specimens were reevaluated. Results: among 1500 patients; 69.9% were women and 30.1% were men. We found out fourteen primary gallbladder carcinomas (0.93%) with adenocarcinomas being the most frequent type (78.57%). The rate of cholelithiasis was found as 89.9%. The most common type of gallstones was mixed cholesterol type gallstones with 67.5% followed by black pigment and brown pigment types as 23.83% and 5.89%, respectively. The association of metaplasia with dysplasia and also gallstones were statistically significant (p<0.001, p<0.005). The rate of the gallbladder polyps was 2.6% with the cholesterol polyps being the most common type (56.4%). Conclusion: Gallbladder diseases often present with similar clinical signs and symptoms and a surgical pathologist should be alert especially of precancerous lesions. With our results, we also conclude that elderly women with longstanding gallstone disease should undergo elective surgery even when no symptoms are present.

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Section: Discussionmentioning

confidence: 99%

Expression of p16 protein and cyclin d1 in periampullary carcinomas

Tuncer

Türk²,

Arici³

et al. 2011

TJPATH

View full text Add to dashboard Cite

show abstract

“…There are several reports from Turkey on the etiological factors of gallstone formation. Pregnancy (12), iron deficiency anemia (13) and bacterial infections such as H. pylori were suggested to have possible roles in the formation of gallstones (14). okumuşoğlu et al (15) reported in their series that cholesterol stones are almost three times as frequent as other types of stones and concluded that this might be related to the dietary habits of Turkish people.…”

Section: Discussionmentioning

confidence: 99%

Expression of p16 protein and cyclin d1 in periampullary carcinomas

Tuncer¹,

Türk²,

Arici³

et al. 2011

TJPATH

View full text Add to dashboard Cite

Objective: Gallbladder is one of the most commonly encountered specimen in a pathology laboratory. a diverse spectrum of diseases affect the biliary system, often presenting with similar clinical signs and symptoms. We aimed to define the profile of gallbladder diseases in our region, and to determine potential correlations between histopathologic features we observed. Material and Method:We reviewed all cholecystectomies processed in Department of Pathology of afyon Kocatepe University Hospital between January 2000 and March 2008. Gross and histopathologic features of the specimens were reevaluated.Results: among 1500 patients; 69.9% were women and 30.1% were men. We found out fourteen primary gallbladder carcinomas (0.93%) with adenocarcinomas being the most frequent type (78.57%). The rate of cholelithiasis was found as 89.9%. The most common type of gallstones was mixed cholesterol type gallstones with 67.5% followed by black pigment and brown pigment types as 23.83% and 5.89%, respectively. The association of metaplasia with dysplasia and also gallstones were statistically significant (p<0.001, p<0.005). The rate of the gallbladder polyps was 2.6% with the cholesterol polyps being the most common type (56.4%). Conclusion:Gallbladder diseases often present with similar clinical signs and symptoms and a surgical pathologist should be alert especially of precancerous lesions. With our results, we also conclude that elderly women with longstanding gallstone disease should undergo elective surgery even when no symptoms are present.

show abstract

“…It is possible that the combination of pregnancy and fascioliasis may have increased the risk of developing stones in this patient. [6][7][8] The risk of gall bladder stones increases in pregnancy, especially in the last two trimesters, because of the alteration in biliary lipid composition and gall bladder hypomotility by sex steroids. 6 Fascioliasis, on the other hand, causes inflammation and hyperplasia of the epithelium, leading to gall bladder edema and mechanical obstruction.…”

Section: Commentmentioning

confidence: 99%

“…[6][7][8] The risk of gall bladder stones increases in pregnancy, especially in the last two trimesters, because of the alteration in biliary lipid composition and gall bladder hypomotility by sex steroids. 6 Fascioliasis, on the other hand, causes inflammation and hyperplasia of the epithelium, leading to gall bladder edema and mechanical obstruction. 7,8 These changes ultimately will cause bile stasis and subsequent development of bile stones.…”

Section: Commentmentioning

confidence: 99%