Risk factors associated with the development of gastric cancer — case-control study

Ramos, Marcus Fernando Kodama Pertille; Júnior, Ulysses Ribeiro; Viscondi, Juliana Kodaira Yukari; Zilberstein, Bruno; Cecconello, Ivan; Eluf‐Neto, José

doi:10.1590/1806-9282.64.07.611

Cited by 33 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main GC carcinogenesis model involves several molecular alterations induced by environmental factors including: 1) high salt intake diets (mostly with high sodium concentrations); 2) poor food conservation; 3) increase in N-nitroso compounds in the gastric mucosa; 4) antioxidants/ vitamin deficiencies (e.g. vitamin C); 5) Helicobacter pylori infection; 6) proinflammatory cytokine gene polymorphisms; 7) prolonged alcohol and tobacco consumption 2,3 . The cumulative effect of these aggressions on the gastric epithelium over the years leads to the development of neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Câncer gástrico em adultos jovens: um grupo de pior prognóstico?

Ramos

Pereira

Sagae

et al. 2019

Rev. Col. Bras. Cir.

Self Cite

View full text Add to dashboard Cite

RESUMO Objetivo: avaliar as características clínico-patológicas e sobrevivência de pacientes jovens, portadores de câncer gástrico, independentemente da intenção de tratamento. Métodos: análise retrospectiva de todos os pacientes com câncer gástrico submetidos a qualquer tratamento cirúrgico entre 2008 e 2017. Pacientes com idade inferior a 45 anos foram considerados adultos jovens, e aqueles com mais de 45 anos foram definidos como grupo com idade avançada. Resultados: dos 875 pacientes avaliados, 84 (9,6%) eram adultos jovens e 791 (90,4%) tinham idade avançada. Jovens associaram-se ao sexo feminino (p<0,001), menor escore de Charlson (p=0,002), ASA I/II (p<0,001), tipo difuso de Lauren (p<0,001) e tumores pouco diferenciados (p<0,001). Não houve diferença entre os grupos quanto à intenção de tratamento (paliativo versus curativo) (p=0,267) e estádio clínico cTNM (p=0,120). A sobrevida livre de doença foi pior nos jovens (p=0,049), mas a sobrevida global foi semelhante entre os grupos (p=0,578). A análise multivariada identificou gastrectomia total, pT3/T4, pN+ e tipo difuso de Lauren como fatores prognósticos associados a pior sobrevida livre de doença e sobrevida global. A idade não foi um fator independente associado a pior prognóstico. Conclusão: apesar de os jovens apresentarem uma menor sobrevida livre de doença, a sobrevida global foi semelhante entre os grupos, e a idade não demonstrou ser um fator prognóstico independente significativo.

show abstract

Section: Introductionmentioning

confidence: 99%

Câncer gástrico em adultos jovens: um grupo de pior prognóstico?

Ramos

Pereira

Sagae

et al. 2019

Rev. Col. Bras. Cir.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In 2017, according to the Korea Central Cancer Registry (KCCR), the age-adjusted incidence rate of GC was 32.0 per 100,000 in the overall population, 46.4 per 100,000 in men, and 19.6 per 100,000 in women [3]. Various epidemiological studies have demonstrated that smoking [4][5][6][7], alcohol consumption [4,5,8], obesity and physical inactivity [4,5,9], family history of GC [10][11][12][13][14], and numerous dietary factors such as foods preserved with salts, pickled vegetables, low fruit and vegetable consumption, low dietary vitamin C and carotenoid intake, high salt consumption, high processed meat consumption, and high salt intake [4,5,15,16] are associated with an increased risk of GC. In addition, some of recent epidemiological studies have suggested the involvement of the gastric microbiome in GC occurrence by the induction of chronic inflammation or down regulation of host immunity [17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Gastric Microbial Communities Are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study

Gunathilake

Lee

Choi

et al. 2020

Cancers

View full text Add to dashboard Cite

Although the microbiome has a potential role in gastric cancer (GC), little is known about microbial dysbiosis and its functions. This study aimed to observe the associations between the alterations in gastric microbial communities and GC risk. The study participants included 268 GC patients and 288 controls. The 16S rRNA gene sequencing was performed to characterize the microbiome. Streptococcus_NCVM and Prevotella melaninogenica species were highly enriched in cases and controls, respectively. Those who were in the third tertile of P. melaninogenica showed a significantly decreased risk of GC in total (odds ratio (OR): 0.91, 95% confidence interval (CI): 0.38–0.96, p-trend = 0.071). Class Bacilli was phylogenetically enriched in cases, while phylum Actinobacteria, class Actinobacteria were related to the controls. The microbial dysbiosis index (MDI) was significantly higher for the cases compared with the healthy controls in the female population (p = 0.002). Females in the third tertile of the MDI showed a significantly increased risk of GC (OR: 2.66, 95% CI: 1.19-5.99, p-trend = 0.017). Secondary bile acid synthesis and biosynthesis of ansamycins pathways were highly abundant in cases and controls, respectively. Dysbiosis of gastric microbial communities is associated with an increased risk of GC specifically in females.

show abstract

“…In 2017, according to the Korea Central Cancer Registry (KCCR), the ageadjusted incidence rate of GC was 32.0 per 100,000 in the overall population, 46.4 per 100,000 in men, and 19.6 per 100,000 in women [3]. Various epidemiological studies have demonstrated that smoking [4][5][6][7], alcohol consumption [4,5,8], obesity and physical inactivity [4,5,9], family history of GC [10][11][12][13][14] and numerous dietary factors such as foods preserved with salts, pickled vegetables, low fruits and vegetables consumption, low dietary vitamin C and carotenoid intake, high salt consumption, high processed meat consumption, high salt intake [4,5,15,16] are associated with the increased risk of GC.…”

Section: Introductionmentioning

confidence: 99%

Alterations in Gastric Microbial Communities are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study

Gunathilake

Lee²,

Choi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Although recent studies have reported the potential role of microbiome in GC, little is known about the microbial dysbiosis and their functions in GC. This study aimed to observe the associations between the alterations in gastric microbial communities and GC risk.Results: The study participants included 268 GC patients and 288 controls. DNA was extracted from gastric biopsies, and 16S rRNA gene analysis was performed to assign into bacterial taxa. Linear discriminant analysis (LDA) effect size (LEfSe) was used to identify differentially abundant taxa and pathways. Compositionality corrected by renormalization and permutation (CCREPE) was applied to derive microbial dysbiosis index (MDI). Microbiota metabolic pathways were analyzed using Phylogenetic Investigation of Communities by Reconstruction of Observed States (PICRUSt) based on the Kyoto Encyclopedia of Genes and Genomes (KEGG). Based on LEfSe, Streptococcus_NCVM and Prevotella melaninogenica species were highly enriched in GC cases and controls, respectively. Those who are in the third tertile of Prevotella melaninogenica showed a significantly decreased risk of GC in total (odds ratio (OR): 0.91, 95% confidence interval (CI): 0.38-0.96, p-trend=0.071). In the cladogram, class Bacilli was phylogenetically enriched in GC cases while phylum Actinobacteria, class Actinobacteria were phylogenetically related in the controls. MDI was significantly higher for the GC cases compared to the healthy controls in the female population (p=0.002). Females, those who are in the third tertile of the MDI showed a significantly increased risk of GC (OR: 2.66, 95% CI: 1.19-5.99, p-trend=0.017; model II). There was a significant inverse correlation between MDI and Shannon index for the total population (R=-0.83, p<0.001). Secondary bile acid synthesis and biosynthesis of ansamycins pathways were highly abundant in cases and controls, respectively.Conclusion: There is a significantly higher MDI in GC cases than controls and further, MDI is significantly positively associated with GC risk in the female population. Biosynthesis of ansamycins is a critical function which is highly enriched in healthy controls. Further microbiome studies are needed to confirm the findings of the current study.

show abstract

Risk factors associated with the development of gastric cancer — case-control study

Cited by 33 publications

References 22 publications

Câncer gástrico em adultos jovens: um grupo de pior prognóstico?

Câncer gástrico em adultos jovens: um grupo de pior prognóstico?

Alterations in Gastric Microbial Communities Are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study

Alterations in Gastric Microbial Communities are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study

Contact Info

Product

Resources

About