Risk factors associated with the development of ischemic colitis

Abstract

The development of an episode of IC was independently associated with diabetes, dyslipidemia, presence of heart failure, peripheral arterial disease and treatment with digoxin or ASA.

Clinical Characteristics of Young-Onset Ischemic Colitis

“…Furthermore, multivariate logistic regression analysis revealed that a smoking habit and hyperuricemia were factors significantly associated with IC development in young adults. These It is generally accepted that IC predominantly develops in the elderly, especially in those aged more than 60 years [3][4][5][6][7][8][9][10][11]. However, in our study, approximately 15% of all adult patients diagnosed as having IC were 20-45 years of age.…”

“…Constipation is reported to be one of the risk factors of IC [4,8]. The prevalence of constipation in young IC patients was comparatively high and tended to be higher than that in young healthy adults, but this difference did not reach statistical significance.…”

“…Generally speaking, IC is considered to occur in the elderly having underlying disorders [3][4][5][6][7][8][9][10][11]. According to previous reports, vascular/hemodynamic and intestinal factors, as well as some kinds of medications, including contraceptive pills, vasoconstrictors, psychotropic drugs, non-steroidal antiinflammatory drugs, and 5-hydroxytriptamine three receptor antagonists, are associated with the pathogenesis of IC.…”

“…According to previous reports, vascular/hemodynamic and intestinal factors, as well as some kinds of medications, including contraceptive pills, vasoconstrictors, psychotropic drugs, non-steroidal antiinflammatory drugs, and 5-hydroxytriptamine three receptor antagonists, are associated with the pathogenesis of IC. Vascular disorders include hypertension [3], dyslipidemia [4], diabetes mellitus [5], atrial fibrillation [6], cardiovascular disease [7,8], cerebral infarction [9], and chronic renal failure [7,10], while intestinal factors mainly comprise constipation [8] and history of abdominal operation [7,8,11].…”

Incidence of Ischemic Colitis in Treated, Commercially Insured Hypertensive Adults: A Cohort Study of US Health Claims Data

“…It occurs when colonic blood flow becomes insufficient because of systemic changes in circulation or local changes in the mesenteric vasculature [4]. Often, the precipitating cause of an ischemic event cannot be established [5].…”