Clinical Characteristics of Young-Onset Ischemic Colitis

Kimura, Takefumi; Shinji, Akihiro; Horiuchi, Akira; Nagaya, Tadanobu; Shigeno, Takashi; Nakamura, Naoshi; Komatsu, Michiharu; Umemura, Takeji; Arakura, Norikazu; Matsumoto, Akihiro; Tanaka, Naoki

doi:10.1007/s10620-012-2088-5

Cited by 41 publications

(36 citation statements)

References 48 publications

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“…The elder the patients, the higher the incidence of the disease; however, ischemic colitis has been increasingly recognized in younger individuals with identifiable causes including vasculitis, hypercoagulable states, certain medications and cocaine abuse . Younger individuals account for 10–15% of all cases; however, it could exceed 34% in some studies …”

Section: Discussionmentioning

confidence: 99%

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Sherid

Sifuentes

Samo

et al. 2014

J of Digest Diseases

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Section: Discussionmentioning

confidence: 99%

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Sherid

Sifuentes

Samo

et al. 2014

J of Digest Diseases

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“…Obesity was defined as BMI >25 kg/m 2 based on criteria released by the Japan Society for the Study of Obesity . Hypertension was determined as systolic pressure >140 mmHg and/or diastolic pressure >90 mmHg or the use of antihypertensive drugs . Diabetes mellitus (DM) was judged as fasting blood sugar (FBS) >120 mg/dL or hemoglobin A1c (HbA1c) >6.5% after conversion into National Glycohemoglobin Standardization Program values or the use of glucose‐lowering drugs .…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological characteristics of non‐B non‐C hepatocellular carcinoma without past hepatitis B virus infection

Kimura

Kobayashi

Sakai

et al. 2016

Hepatology Research

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“…At the time of admission, blood samples were obtained in a fasting state and complete blood counts and blood chemistries were determined by standard methods [23,24]. Free FAs and ketone bodies were measured enzymatically (http://www.srl-group.co.jp, SRL, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα

Komatsu

Kimura

Yazaki

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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SLC25A13 (citrin or aspartate-glutamate carrier 2) is located in the mitochondrial membrane in the liver and its genetic deficiency causes adult-onset type II citrullinemia (CTLN2). CTLN2 is one of the urea cycle disorders characterized by sudden-onset hyperammonemia due to reduced argininosuccinate synthase activity. This disorder is frequently accompanied with hepatosteatosis in the absence of obesity and ethanol consumption. However, the precise mechanism of steatogenesis remains unclear. The expression of genes associated with fatty acid (FA) and triglyceride (TG) metabolism was examined using liver samples obtained from 16 CTLN2 patients and compared with 7 healthy individuals. Although expression of hepatic genes associated with lipogenesis and TG hydrolysis was not changed, the mRNAs encoding enzymes/proteins involved in FA oxidation (carnitine palmitoyl-CoA transferase 1α, medium- and very-long-chain acyl-CoA dehydrogenases, and acyl-CoA oxidase 1), very-low-density lipoprotein secretion (microsomal TG transfer protein), and FA transport (CD36 and FA-binding protein 1), were markedly suppressed in CTLN2 patients. Serum concentrations of ketone bodies were also decreased in these patients, suggesting reduced mitochondrial β-oxidation activity. Consistent with these findings, the expression of peroxisome proliferator-activated receptor α (PPARα), a master regulator of hepatic lipid metabolism, was significantly down-regulated. Hepatic PPARα expression was inversely correlated with severity of steatosis and circulating ammonia and citrulline levels. Additionally, phosphorylation of c-Jun-N-terminal kinase was enhanced in CTLN2 livers, which was likely associated with lower hepatic PPARα. Collectively, down-regulation of PPARα is associated with steatogenesis in CTLN2 patients. These findings provide a novel link between urea cycle disorder, lipid metabolism, and PPARα.

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Clinical Characteristics of Young-Onset Ischemic Colitis

Abstract: High prevalences of a smoking habit and hyperuricemia are characteristic features of IC in the young adult population.

Cited by 41 publications

References 48 publications

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Clinicopathological characteristics of non‐B non‐C hepatocellular carcinoma without past hepatitis B virus infection

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα

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