Risk factors contributing to the difference in prognosis for papillary versus micropapillary thyroid carcinoma

Karatzas, Theodore; Vasileiadis, Ioannis; Kapetanakis, Stylianos; Karakostas, Efthimios; Chrousos, George P.; Kouraklis, Gregory

doi:10.1016/j.amjsurg.2013.02.008

Cited by 54 publications

(54 citation statements)

References 33 publications

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“…Our experience only partly confirms the literature on multifocality and bilaterality as the percentage of multifocality was lower (15.66%), albeit slightly, compared with that reported by other authors, and only in 7,23% we observed bilaterality of neoplastic lesions. However, the data resulting from postoperative scintigraphic controls (57.69% of lymph node metastasis detected) gives us the validation of our approach and some authors agree with us (23,(79)(80)(81)(82). On the contrary some Authors do not share this setting (83)(84)(85)(86)(87)(88)(89)(90)(91) and others suggest a stratification of the risk of recurrence based on the presence of BRAF mutation, extrathyroidal extension, lateral neck lymph node metastases, multifocality, TSH levels, molecular markers, high metabolic tumor volume and tumor stage (92)(93)(94)(95)(96)(97)(98)(99)(100)(101)(102).…”

Section: Discussionsupporting

confidence: 60%

Incidental thyroid carcinomas. A retrospective study

Maturo¹

2017

GCHIR

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Section: Discussionsupporting

confidence: 60%

Incidental thyroid carcinomas. A retrospective study

Maturo¹

2017

GCHIR

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“…ITMCs have significantly fewer aggressive characteristics than conventional TC. NITMC, which presents with aggressive features like conventional TC, should be treated in a similar manner and a routine total thyroidectomy with central lymph node compartment dissection should be performed (35). Similar observations were noted in a study by Vasileiadis et al (36), which recorded 339 individuals with the papillary type of TMC, accounting for 12% of all patients who underwent surgery for thyroid disease.…”

Section: Tumor Size MM ---------------------------------------------supporting

confidence: 65%

Incidental and non-incidental thyroid microcarcinoma

et al. 2016

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Abstract. There is no clear therapeutic approach for thyroid microcarcinoma (TMC). This may be as a consequence of recent observations that have reported biologically different types of TMC, which should be treated differently. The objective of the present study was to compare incidental TMC (ITMC) and non-incidental TMC (NITMC) in order to assess the differences in the incidence, diagnostic results, clinicopathological characteristics and surgical treatment. The study consisted of a retrospective chart review of 3,218 patients consecutively admitted and surgically treated in a single institution due to thyroid pathology. A total of 246 (7.64%) patients presented with a thyroid malignancy, and 97 (39.43%) of these individuals were diagnosed with TMC; 37 (38.14%) patients exhibited ITMC and 60 (61.86%) exhibited NITMC. All 37 (100.00%) patients with ITMC exhibited a papillary type of cancer. In the NITMC group, 1 (1.67%) patient presented with follicular microcarcinoma, 1 (1.67%) individual with papillary-and follicular-type microcarcinoma, 1 (1.67%) individual with medullary microcarcinoma, and the remaining 57 (95.00%) patients presented with papillary microcarcinoma. The number of younger patients (<45 years old) was higher in the NITMC group, but this difference was not significant (P=0.205). In all patients with ITMC, ultrasound-guided fine-needle aspiration biopsy did not reveal malignant processes. In the NITMC group, the number of larger tumors (>5 mm) was significantly higher compared with that in the ITMC group (P<0.001). ITMC was significantly associated with multinodular goiter (MNG) (P<0.001). Amongst the NITMC group, 18.33% of patients presented with cervical lymph node involvement (P<0.001). Overall, the incidence of TMC is high, and consists of ITMC and NITMC, although the prevalence of NITMC is higher than that of ITMC. The majority of ITMCs and NITMCs are composed of a papillary type of cancer. The majority of ITMCs have dimensions ≤5 mm in diameter and are significantly associated with MNG. In comparison with ITMC, NITMC more often presents with aggressive features such as cervical lymph node metastases, so the surgical approach to this tumor should be more radical.

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“…The average age of these patients was 56.7 years at diagnosis, higher than the average age of 45.4 years among those staged as pT1N0/N1, pT2N0/N1, pT3N0. Associations with older age (1,11), multifocality (7,10), and the presence of lymph node metastases (7,12) with advanced stages and prognosis were reported in differentiated thyroid carcinoma. Of the 68 patients who had differentiated carcinoma and developed distant metastases (9.2%), 46 were age 50 years or older at the diagnosis of their primary tumors, three of whom were less than 20 years old (mean 55.2 years).…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital

Cavalheiro

Matos

Leite

et al. 2016

Arch. Endocrinol. Metab.

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Objective: The aim of the present study was to describe the epidemiologic data, histological type, treatment and follow-up of the 811 patients treated for thyroid cancer in Instituto do Câncer do Estado de São Paulo (ICESP) over 5 years. Materials and methods: Retrospective analyses of electronic chart information. Results: There were 679 cases (83.7%) of papillary thyroid cancer, 61 (7.5%) of follicular carcinoma, 54 (6.7%) of medullary carcinoma, 11 (1.4%) of poorly differentiated carcinoma and 6 of anaplastic carcinoma (0.7%). The majority of patients were female (82.2%), and the mean age was 50.5 ± 15 years. Two hundred forty-two patients had disease persistence or recurrence. At the last follow-up, 629 (77.6%) patients were alive and disease free, 141 (17.4%) were alive with disease, and 41 (5.1%) were deceased, with 37 deaths related to thyroid cancer. Conclusion: This study was able to outline the profile, disease type and evolution of patients treated for thyroid cancer at a single tertiary hospital. Arch Endocrinol Metab. 2016;60(5):472-8

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Risk factors contributing to the difference in prognosis for papillary versus micropapillary thyroid carcinoma

Cited by 54 publications

References 33 publications

Incidental thyroid carcinomas. A retrospective study

Incidental thyroid carcinomas. A retrospective study

Incidental and non-incidental thyroid microcarcinoma

Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital

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