Risk Factors, Coronary Severity, Outcome and ABO Blood Group

Zhang, Yan; Li, Sha; Zhu, Cheng‐Gang; Guo, Yuan‐Lin; Wu, Na‐Qiong; Xu, Rui‐Xia; Dong, Qian; Li, Geng; Li, Jianjun

doi:10.1097/md.0000000000001708

Cited by 25 publications

(26 citation statements)

References 29 publications

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“…Second, a multiplier was assigned to each main vascular segment based on the functional significance of the myocardial area supplied by that segment: 5 for the left main coronary artery, 2.5 for the proximal segment of the left anterior descending (LAD) coronary artery, and the proximal segment of the circumflex artery, 1.5 for the mid-segment of the LAD, 1.0 for the right coronary artery, the distal segment of the LAD, mid-distal region of the circumflex artery, the posterolateral artery, and the obtuse marginal artery, and 0.5 for small segments. 15,18 Follow-Up…”

Section: Severity Assessment Of Coronary Atherosclerosismentioning

confidence: 99%

Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease

Gong

Yang

Sha

et al. 2016

Clin Appl Thromb Hemost

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Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiographic-proven patients with CAD were consecutively enrolled. Then, all patients were subjected to follow up for an average of 18 months (ranged from 14 to 1037 days). The relationships of the plasma d-dimer with the severity of CAD and future clinical outcomes were evaluated. We found that plasma d-dimer was higher in patients with prior myocardial infarction (MI) than that in patients with nonprior MI (P = .006). Multivariate linear regression analysis suggested that the plasma d-dimer was linked to the severity of CAD assessed by Gensini score (β = 0.052, 95% confidence interval [CI]: 1.20-6.84, P = .005) even after adjusting for confounding factors. During the follow-up, 42 patients underwent prespecified outcomes. After adjustment for multiple variables in the Cox regression model, the d-dimer levels remained to be a potential predictor of total outcome (hazard ratio = 1.22, 95% CI: 1.09-1.37, P = .001). Therefore, plasma d-dimer levels appeared to be a useful predictor for the severity of CAD and the subsequent major clinical events.

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Section: Severity Assessment Of Coronary Atherosclerosismentioning

confidence: 99%

Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease

Gong

Yang

Sha

et al. 2016

Clin Appl Thromb Hemost

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“…Clinical trials determined that blood group types are associated with CAD. 5,[26][27] A recent meta-analysis confirmed that non-O blood groups appear to be an independent risk factor for CAD and myocardial infarction. 28 Non-O blood groups have been found to show a significant relationship with family history of CAD and hypercholesterolemia, and this might be a possible genetic interaction between blood groups and CAD.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, it is acknowledged that blood type groups are associated with CAD. 4,5 Genome-wide association studies have determined a significant association between the blood type group genes and inflammatory marker genes. [6][7][8][9] Blood group types frequency is different in different areas of the world.…”

Section: Introductionmentioning

confidence: 99%

Blood Group Types O and Non-O Are Associated With Coronary Collateral Circulation Development

Celebi

Çelebi²,

Berkalp

et al. 2020

Clin Appl Thromb Hemost

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Blood group types are associated with coronary artery disease. However, data are scarce about the impact of blood group types on coronary collateral circulation. In this study, we aimed to investigate the relationship between the blood group types and coronary collateral circulation. Two hundred and twelve patients who underwent coronary angiography in our department and had a stenosis of ≥ 90% in at least one major epicardial vessel were included in our study. Collateral degree was graded according to Rentrop-Cohen classification. After grading, patients were divided into poor coronary collateral circulation (Rentrop grade 0 and 1) and good coronary collateral circulation (Rentrop 2 and 3) groups. The ABO blood type of all participants was determined. The incidence rates of O blood group type were significantly higher in the good coronary collateral group compared to the poor collateral group (37.9% vs 17.1%, P < .001). The O type blood group was an independent predictor of good coronary collateral circulation (odds ratio = 1.83, 95% confidence interval = 1.56-6.18, P = .015). Coronary collateral circulation is associated with blood group types. The O blood group predicts good coronary collateral development among patients with coronary artery disease.

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“…The ABO blood group is considered an overarching genetic determinant of CVD risk [7]. Advances in technology, biochemistry, and genetics have clarified to a plausible extent the association of blood group typesespecially the human blood group antigens, A, B, and H (O)and their relationship to risk for disease [8].…”

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confidence: 99%

“…Extensive, evidence-based, scientific validation has substantiated the association between ABO blood groups and diseases such as cancer, infection, coagulation disorders, diabetes, and CVD [8,9]. Thus, the study of ABO blood group phenotypes remains a fascinating field, given its role in the pathogenesis of different diseases, particularly CVD [7,9]. The influence of ABO blood groups on the cardio-metabolic health status of an individual is multifaceted, because MUH status and the risk of CVD is a multi-factorial condition that is not controlled by just a single blood group antigen [8].…”

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confidence: 99%

Metabolic health status and cardiovascular risk of different ABO blood group phenotypes

Anioke¹

2019

Int J Med Biochem

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Metabolic health status and cardiovascular risk of different ABO blood group phenotypes C linically, certain cardio-metabolic risk determinants often occur in a cluster of components of obesity, dyslipidemia, hypertension, and hyperglycemia [1]. This formed the basis of the definition of metabolic syndrome (MetSyn). Various sets of criteria for the diagnosis of MetSyn have been proposed using a different number and combination of these compo-Objectives: ABO blood group antigens could play a role in the pathogenesis of cardiovascular disease (CVD). This study examined the metabolic health status (MHS) and CVD risk of apparently healthy individuals from across the ABO blood group system. Methods: Demographic details as well as anthropometric and biochemical data were collected in a cross-sectional survey from 120 participants of different ABO groups (range: 18-70 years). Height, weight, and waist circumference were measured using standard procedures. Body mass index was calculated as weight divided by height squared (kg/ m 2). A blood sample of approximately 5 mL was collected after an overnight fast. Fasting blood glucose was estimated using a glucometer. The blood group was determined using a monoclonal ABO blood grouping reagent. Direct enzymatic methods and a commercial kit were used to measure the level of total cholesterol (TC), triglycerides, and highdensity lipoprotein. Low-density lipoprotein (LDL) and very low-density lipoproteins were estimated using the Friedewald equation. Metabolically healthy (MH) and metabolically unhealthy (MUH) individuals were identified based on the presence of metabolic syndrome using the Joint Interim Statement criteria. CVD risk was determined using the Systematic Coronary Risk Evaluation chart. Results: Females showed significant differences in TC across the ABO system: The O group (mean±SD: 4.85±0.77 mmol/L) demonstrated a significantly higher TC level compared with the A group (mean±SD: 4.22±0.72 mmol/L; p=0.015). The LDL in females was also significantly higher in the O group samples (mean±SD: 3.06±0.75 mmol/L) compared with the A samples (mean±SD: 2.53±0.62 mmol/L; p=0.042). There was no significant difference between the MUH and MH groups based on ABO blood phenotype (p>0.05). The CVD risk among those with the O phenotype (51.7%) was significantly higher than in the non-O blood groups among male subjects (χ 2 =6.213; p=0.045). Conclusion: MHS was not associated with the ABO system, but there is a possibility that male members of blood group O are more susceptible to CVD than men with non-O phenotypes.

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Risk Factors, Coronary Severity, Outcome and ABO Blood Group

Abstract: Supplemental Digital Content is available in the text

Cited by 25 publications

References 29 publications

Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease

Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease

Blood Group Types O and Non-O Are Associated With Coronary Collateral Circulation Development

Metabolic health status and cardiovascular risk of different ABO blood group phenotypes

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