Risk factors for acquisition of Methicillin-resistant Staphylococcus aureus among patients from a burn unit in Brazil

Olivo, Taylor Endrigo Toscano; Melo, Edson Carvalho de; Rocha, Cristiane; Fortaleza, Carlos Magno Castelo Branco

doi:10.1016/j.burns.2009.02.008

Cited by 12 publications

(2 citation statements)

References 31 publications

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“…For example, MRSA strains have been rarely encountered in the Netherlands so far [ 34 ], and classical SID regimen developers consider this method unsuitable for geographic areas with high MRSA prevalence [ 36 ]. Moreover, MRSA is an important pathogen causing infectious complications in burn patients in many countries [ 63 – 66 ] and, in particular, in Russia [ 67 – 69 ]. A large prospective study conducted in Spain [ 70 ] involved two groups: 402 patients for whom only barrier and isolation measures were used to prevent contamination of burns from the environment (group 1), and 375 patients (group 2) receiving SID according to standard regimen + enteral vancomycin (500 g orally 4 times a day, 4% vancomycin paste for intranasal and oropharyngeal application).…”

Section: The Use Of Selective Intestinal Decontamination In Burn Patientsmentioning

confidence: 99%

Selective Intestinal Decontamination as a Method for Preventing Infectious Complications (Review)

Барсук¹,

Nekaeva²,

Ловцова³

et al. 2020

Sovrem Tehnol Med

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Infectious complications are the most common cause of death in patients with severe burns. To date, there is no generally accepted method for preventing such complications in burn injury. One of the possible prevention options is selective intestinal decontamination (SID). This method is based on the enteral administration of non-absorbable antimicrobial agents. The preventive effect of SID involves inhibition of intestinal microflora translocation through the mucous membranes, inasmuch as studies demonstrate that endogenous opportunistic microorganisms are a common cause of infectious complications in various critical conditions. The SID method was originally developed in the Netherlands for patients suffering from mechanical injury. Antimicrobial drugs were selected based on their high activity in relation to the main endogenous opportunistic pathogens and minimal activity against normal intestinal microflora components. The combination of polymyxin (B or E), tobramycin, and amphotericin B with intravenous cefotaxime was chosen as the first SID regimen. Other regimens were proposed afterwards, and the application field of the method was expanded. In particular, it became the method of choice for prevention of infectious complications in patients with severe burn injury. Clinical studies demonstrate efficacy of some SID regimens for preventing infectious complications in patients with thermal injury. Concomitant administration of SID and systemic preventive antibiotics and addition of oropharyngeal decontamination increases the method efficacy. SID is generally well-tolerated, but some studies show an increased risk of diarrhea with this preventive option. In addition, SID increases the risk of developing antibiotic resistance like any other antibiotic regimens.

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Section: The Use Of Selective Intestinal Decontamination In Burn Patientsmentioning

confidence: 99%

Selective Intestinal Decontamination as a Method for Preventing Infectious Complications (Review)

Барсук¹,

Nekaeva²,

Ловцова³

et al. 2020

Sovrem Tehnol Med

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“…Staphylococcus aureus ( S. aureus ) is one of the most common causes of infection among patients with severe burn wounds [1, 2]. Colonization of burn wounds with S. aureus can cause septicemia and substantially increase mortality rate [3]. The pathogenicity of S. aureus strains depends on different virulence factors such as Panton-Valentine leukocidin (PVL), staphylococcal enterotoxins, and hemolysins alpha, beta, gamma, and delta [4].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of direct repeat unit types of 10di, 8 h and 8i among methicillin resistant Staphylococcus aureus strains with staphylococcal cassette chromosome mec type IIIA isolated in Tehran, Iran

Motallebi

Jabalameli

Beigverdi

et al. 2019

Antimicrob Resist Infect Control

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Background The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a main concern in burn care centers worldwide. The some reports of MRSA in Iran suggested that MRSA with type SCC mec III is common among burn patients. The aim of this study was to determine the prevalence, virulence genes, and antimicrobial susceptibility of the direct repeat units ( dru ) types of MRSA with SCC mec IIIA isolated from burn wounds in a burn care center in Tehran, Iran. Methods In total, 165 S. aureus isolates were collected from clinical samples. In order to detect MRSA isolates, the mec A gene was amplified through the polymerase chain reaction (PCR) method. Antimicrobial susceptibility was tested using the disc agar diffusion test. Moreover, the PCR method was applied to determine SCC mec types, virulence genes, and antimicrobial resistance genes. The dru region was sequenced and thereby, dru types and dru repeats were identified. A similarity matrix was used to create minimum spanning tree (MST). Results The prevalence of MRSA was 69% (114 out of 165 isolates). Most of MRSA isolates (61 out of 114, 53.5%) were SCC mec type IIIA. All MRSA isolates were vancomycin-susceptible and more than 68% of MRSA isolates with SCC mec type IIIA were mupirocin resistant. The successful dru typing of isolates with SCC mec type IIIA revealed fourteen different dru types. There were two new dru types, namely dt10di and dt7aj. MST analysis indicated the presence of the three clusters of dt10di (cluster I), dt8i-dt8 h (cluster II), and dt11c-dt10ao-dt11dd-dt11a-dt10a (cluster III). There were significant differences between clusters I and II respecting antimicrobial resistance pattern and virulence genes. Conclusion Three main dru clusters are prevalent in the study setting. The main dru types in the setting are dt10di, dt8i, and dt8 h. Dru typing can be used to differentiate MRSA strains with SCC mec IIIA.

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A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients

Shahsavan¹,

Emaneini²,

Khoshgnab³

et al. 2012

Burns

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Risk factors for acquisition of Methicillin-resistant Staphylococcus aureus among patients from a burn unit in Brazil

Cited by 12 publications

References 31 publications

Selective Intestinal Decontamination as a Method for Preventing Infectious Complications (Review)

Selective Intestinal Decontamination as a Method for Preventing Infectious Complications (Review)

High prevalence of direct repeat unit types of 10di, 8 h and 8i among methicillin resistant Staphylococcus aureus strains with staphylococcal cassette chromosome mec type IIIA isolated in Tehran, Iran

A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients

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