Risk factors for basal cell carcinoma in a southern Brazilian population: a case–control study

Gon, and Airton; Minelli, Lorivaldo

doi:10.1111/j.1365-4632.2011.04947.x

Cited by 19 publications

(21 citation statements)

References 8 publications

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“…Although the markers of interest used in this study were not prone to recall bias, in most studies it was unclear if observers were blinded to skin cancer status before examination, potentially resulting in biased assessments (47)(48)(49)(50)(51). The most likely result of this would have been to overestimate the association between chronic skin damage and BCC.…”

Section: Discussionmentioning

confidence: 75%

Cutaneous Markers of Photo-Damage and Risk of Basal Cell Carcinoma of the Skin: A Meta-Analysis

Khalesi

Whiteman

Doi

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between histologically confirmed BCC and actinic keratoses, solar elastosis, solar lentigines, or telangiectasia. Seven eligible studies were identified and summary odds ratios (ORs) were calculated using both random and quality effects models. Having more than ten actinic keratoses was most strongly associated with BCC, conferring up to a fivefold increase in risk (OR: 4.97; 95% CI: 3.26-7.58). Other factors, including solar elastosis, solar lentigines, and telangiectasia had weaker but positive associations with BCC with ORs around 1.5. Markers of chronic photo-damage are positively associated with BCC. The presence of actinic keratoses was the most strongly associated with BCC of the markers examined. This work highlights the relatively modest association between markers of chronic ultraviolet exposure and BCC. Cancer Epidemiol Biomarkers Prev; 22(9);

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Section: Discussionmentioning

confidence: 75%

Cutaneous Markers of Photo-Damage and Risk of Basal Cell Carcinoma of the Skin: A Meta-Analysis

Khalesi

Whiteman

Doi

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Indeed, some studies showed no effect of sunscreen use on BCC prevention. In a case-control Italian study [178], the frequent use of sunscreens entailed a non-significant protective effect (OR 0.6, 95% CI 0.3-1.4) and a recent Brazilian case-control study carried out in subjects aged 18-80 years found no effect of sunscreen or protective clothing use on BCC risk [179]. Finally, two cohort studies did not show a decrease in SCC or BCC risk with sunscreen use after adjusting for skin phenotype and sun-exposure [180,181].…”

Section: Preventionmentioning

confidence: 94%

Update of the European guidelines for basal cell carcinoma management

Trakatelli¹,

Morton²,

Nagore³

et al. 2014

European Journal of Dermatology

204

197

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Background European guidelines for the management of basal cell carcinoma (BCC) prepared by the former BCC subcommittee of the Guidelines Committee of the European Dermatology Forum (EDF) were published in 2006. Objectives To present updated guidelines that include consensual expert definitions on various BCC types, prognosis and risk factors for BCC as well as review recommendations for diagnosis and treatment reflecting current published evidence. Methods These guidelines (S1 type) were prepared by the new BCC subgroup of the European Dermatology Forum (EDF)'s Guidelines Committee through extensive literature review (up to 2012) and expert experience; they were extensively discussed within the EDF subcommittee and approved by peer reviewers of the EDF. Results BCC is a common tumour with an incidence rising worldwide. Three major clinical types of BCC are recognized: nodular, superficial and morpheaform. Four histological subtypes are defined: superficial, nodular, infiltrative and morpheaform. On the basis of the risk of relapse, three prognosis groups have been identified: high, intermediate and low risk. According to these classifications and evidence-based evaluation of the therapeutic strategies available, a decision tree is proposed for the management of BCCs. Conclusions. The guidelines offer a useful tool that will help dermatologists to select the most appropriate treatment for individual patients.

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“… 3 , 20 Other environmental factors which related to increased incidence of skin cancers were the ozone layer depletion and living in high altitude, low latitude areas. 22 Among individual risk factors, 9 , 12 , 20 , 21 fair skin, age above 40 years, genetic predisposition (albinism, xeroderma pigmentosum, epidermodysplasia verruciformis, and basal-cell nevus syndrome), and immunosuppression. Absent or improper skin protection during professional activities or leisure times allows for sunburns, mainly during childhood and adolescence, which leads to increased skin cancer risk.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 20 Outros fatores ambientais relacionados à maior incidência de câncer de pele são a redução da camada de ozônio e viver em regiões de alta altitude e baixa latitude. 22 Entre os fatores de risco individuais, 9 , 12 , 20 , 21 encontram-se pele clara, idade acima de 40 anos, predisposição genética (albinismo, xeroderma pigmentoso, epidermodisplasia verruciforme e síndrome do nevo basocelular) e imunossupressão. A ausência ou a inadequada proteção da pele nas atividades laborais e nos momentos de lazer propiciam queimaduras solares, principalmente na infância e adolescência, o que leva ao aumento do risco de câncer de pele.…”

Section: Introductionunclassified

Multiple skin neoplasms in subjects under 40 years of age in Goiania, Brazil

2015

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OBJECTIVE To describe the trend for malignant skin neoplasms in subjects under 40 years of age in a region with high ultraviolet radiation indices.METHODS A descriptive epidemiological study on melanoma and nonmelanoma skin cancers that was conducted in Goiania, Midwest Brazil, with 1,688 people under 40 years of age, between 1988 and 2009. Cases were obtained from Registro de Câncer de Base Populacional de Goiânia (Goiania’s Population-Based Cancer File). Frequency, trends, and incidence of cases with single and multiple lesions were analyzed; transplants and genetic skin diseases were found in cases with multiple lesions.RESULTS Over the period, 1,995 skin cancer cases were observed to found, of which 1,524 (90.3%) cases had single lesions and 164 (9.7%) had multiple lesions. Regarding single lesions, incidence on men was observed to have risen from 2.4 to 3.1/100,000 inhabitants; it differed significantly for women, shifting from 2.3 to 5.3/100,000 (Annual percentage change – [APC] 3.0%, p = 0.006). Regarding multiple lesions, incidence on men was observed to have risen from 0.30 to 0.98/100,000 inhabitants; for women, it rose from 0.43 to 1.16/100,000 (APC 8.6%, p = 0.003). Genetic skin diseases or transplants were found to have been correlated with 10.0% of cases with multiple lesions – an average of 5.1 lesions per patient. The average was 2.5 in cases without that correlation.CONCLUSIONS Skin cancer on women under 40 years of age has been observed to be increasing for both cases with single and multiple lesions. It is not unusual to find multiple tumors in young people – in most cases, they are not associated with genetic skin diseases or transplants. It is necessary to avoid excessive exposure to ultraviolet radiation from childhood.

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Risk factors for basal cell carcinoma in a southern Brazilian population: a case–control study

Cited by 19 publications

References 8 publications

Cutaneous Markers of Photo-Damage and Risk of Basal Cell Carcinoma of the Skin: A Meta-Analysis

Cutaneous Markers of Photo-Damage and Risk of Basal Cell Carcinoma of the Skin: A Meta-Analysis

Update of the European guidelines for basal cell carcinoma management

Multiple skin neoplasms in subjects under 40 years of age in Goiania, Brazil

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