Risk factors for central line-associated bloodstream infection in pediatric oncology patients with a totally implantable venous access port: A cohort study

Abstract

Risk factors for CLABSI in pediatric cancer patients with a TIVAP may be related to the severity of the child's condition at catheter insertion. Insertion of the catheter before chemotherapy and unfavorable conditions such as malnutrition and bone marrow aplasia can increase the risk of CLABSI. Protocols must be revised and surveillance increased over the first 10 weeks of treatment.

Infection surveillance in pediatric hematopoietic stem cell transplantation recipients

“…20 This is also shown in another national study, which presented an ID of 1.2 per 1000 CVC-days in pediatric HSCT patients. 12 Moreover, in our study, the ID of CVC-LC-BSI was 50% higher in patients with a permanent CVC, although this did not reach statistical significance (P = .79). In the study conducted by Besides, Libbrecht et al, 21 in a multivariate analysis, showed that grafts from unrelated donors were found to be an independent risk factor for bacteremia (P = .003).…”

“…A national study also showed a similar proportion of GNB (46.8%), but coagulase-negative staphylococci were the most prevalent. 12 In another recent study, in Egypt, including all LC-BSIs not associated with CVCs, gram-positive bacteria were the most commonly encountered, whereas GNB comprised 43% of the isolated microorganisms. 26 The percentage of infections attributed to coagulase-negative staphylococci was also important.…”

“…11 Although HSCT has been performed since the late 1970s in Brazil, few studies have thus far addressed its distinctive infectious features and complications in children and adolescents in our country. 3,12 Bearing this in mind, the objective of this study was to describe the profile of reported infections in pediatric patients submitted to HSCT at a Pediatric Hematology and HSCT reference center in Brazil.…”

Early central line‐associated blood stream infections in children with cancer pose a risk for premature catheter removal

“…Previous studies of CLABSI in children undergoing cancer treatment have identified several risk factors, such as failure to observe hygiene procedures, longer duration of catheterisation, more frequent CVC manipulation, double‐lumen catheters, young age, chronic malnutrition and an absolute neutrophil count of <0.5 × 109/L . However, the varying infection rates that have been reported probably reflect the different methodology used and the differences in patient cohorts.…”

Totally Implantable Central Venous Port Catheters: Radiation Exposure as a Function of Puncture Site and Operator Experience

“…A central venous access is mandatory for hyperosmolar, basic (pH ≤4.0), alkaline (pH ≥9.0) and local irritant medication, such as chemotherapy, antibiotics and parenteral nutrition. Moreover, high pressure infusions such as those required for computed tomographic examinations of up to 5 ml/s, as well as blood tests, which can be performed through such selected systems, streamlining workflow and increasing patient quality of life (1)(2)(3).…”