Risk Factors for Classical Kaposi's Sarcoma

Goedert, James J.; Vitale, Francesco; Lauria, Carmela; Serraino, Diego; Tamburini, Mario; Montella, Maurizio; Messina, Angelo; Brown, Elizabeth E.; Rezza, Giovanni; Gafà, Lorenzo; Romano, Nino

doi:10.1093/jnci/94.22.1712

Cited by 112 publications

(91 citation statements)

References 38 publications

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“…Regarding solid cancers, the deficit for lung cancer, also reported in other studies (Dictor and Attewell, 1988;Biggar et al, 1994;Hjalgrim et al, 1997;Iscovich et al, 1999a, b;Goedert et al, 2002), could be explained by the inverse association between cigarette smoking and CKS (Anderson et al, 2008). However, our results are only in part consistent with this association, in which certain causes of smoking-attributable deaths showed a deficit (smoking-associated vascular mortality: ischaemic heart disease and cerebrovascular disease), whereas others showed an excess (smoking-related respiratory mortality: COPD and allied conditions).…”

Section: Discussionsupporting

confidence: 60%

“…However, our results are only in part consistent with this association, in which certain causes of smoking-attributable deaths showed a deficit (smoking-associated vascular mortality: ischaemic heart disease and cerebrovascular disease), whereas others showed an excess (smoking-related respiratory mortality: COPD and allied conditions). In any case, the literature on the association between CKS and cardiovascular and respiratory diseases is conflicting (Goedert et al, 2002;Guttman-Yassky et al, 2006;Anderson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have found an association (either positive or negative) between CKS and an additional primary cancer, both when CKS was the first primary neoplasm (Franceschi et al, 1996;Hjalgrim et al, 1997;Iscovich et al, 1999a) and when it was the second primary neoplasm (Iscovich et al, 1999b;Hisada et al, 2001), or regardless of the temporal order of diagnosis (Cannon et al, 2000). A few studies have also reported an association (positive or negative) with a variety of non-neoplastic diseases (Goedert et al, 2002;Guttman-Yassky et al, 2006;Anderson et al, 2008). Classic Kaposi's sarcoma is rarely considered to be an actual cause of death (Brambilla et al, 1994;Franceschi et al, 1996;Hiatt et al, 2008).…”

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confidence: 99%

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Cause-specific mortality in classic Kaposi's sarcoma: a population-based study in Italy (1995–2002)

et al. 2009

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BACKGROUND: Little information is available on the causes of death among persons with classic Kaposi's sarcoma (CKS). METHODS: We conducted a population-based study in Italy to identify deceased persons with CKS and the underlying causes of death among them, by reviewing multiple-causes-of-death records. Standardised mortality ratios (SMRs) and 95% confidence intervals were calculated to compare the distribution of causes to that among the same-age general population of deceased persons. The geographical distribution was also evaluated. RESULTS: Of the 946 deaths among persons with CKS, 65.9% were attributable to non-neoplastic conditions and 21.9% to malignancies. For 12.2%, no lethal pathology was identified and CKS was considered as the underlying cause. In 90% of these cases, there was visceral/nodal involvement, therapy-related complications, or neoplastic cachexia. Among persons with CKS who died of other causes, an excess for lymphoid malignancies emerged (SMR ¼ 4.40) (chronic lymphocytic leukaemia (11.03), non-Hodgkin's lymphoma (4.22), Hodgkin's lymphoma (11.80), and multiple myeloma (2.3)), balanced by a deficit for all solid cancers (0.56), with a marked deficit for lung cancer (0.41). We found an excess for respiratory diseases (chronic obstructive pulmonary disease (1.86)) and genitourinary diseases (chronic renal failure (6.47)). There was marked geographical heterogeneity in the distribution of deaths. CONCLUSIONS: Though referring specifically to Italy, the results are informative for other countries and populations and all cases of CKS in general.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Cause-specific mortality in classic Kaposi's sarcoma: a population-based study in Italy (1995–2002)

et al. 2009

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“…This population included 141 CKS cases and 192 KSHV LANA-seropositive controls enrolled between April 13, 1998, andOctober 8, 2001, from Sicily, Rome, and Naples. As described elsewhere (26), CKS cases (International Classification of Disease-Oncology, third edition, M9140/3) were enrolled from population-based cancer registries and major referral centers. Population-based potential controls were screened for KSHV LANA antibodies.…”

Section: Study Populationsmentioning

confidence: 99%

A Common Genetic Variant inFCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma

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Goedert

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome -associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANAseronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II, we examined risk of CKS from 133 CKS cases and 172 KSHV LANA-seropositive controls from Sicily, Rome, and Naples (70% males; median age, 74 years; range, 29-91). FCGR3A variants were determined by direct sequence analysis of a nested PCR of genomic DNA assay using allele-specific primers. KSHV LANA was determined by immunofluorescence assay. Overall, compared with the 158F allele, 158V was overrepresented among controls from both Mediterranean populations (frequency = 0.52 and 0.51, respectively). After controlling for age, 158V homozygous women were at increased risk of KSHV infection and CKS compared with 158F homozygous women [odds ratio (OR), 8.7; 95% confidence interval (95% CI), 0.8-98 and OR, 3.8; 95% CI, 1.0-14, respectively], whereas homozygous men were at decreased risk (OR, 0.4; 95% CI, 0.1-2.3 and OR, 0.4; 95% CI, 0.2-0.8, respectively). Significant gene-dose effects were observed among men and women at risk for CKS (P trend V V V 0.05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance.

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“…In general, the seroprevalence rates of KSHV in different geographical regions correlate with the incidence rates of CKS (Gao et al, 1996;Chatlynne and Ablashi, 1999;Schulz, 1999;Antman and Chang, 2000). Yet, genetic and/or environmental cofactors affecting the risk of CKS after KSHV infection probably play an important role, and thus may modify the relationship between the seroprevalence of KSHV and incidence of KS (Ariyoshi et al, 1998;Goedert et al, 2002;Grossman et al, 2002).…”

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confidence: 99%

Epidemiology of classic Kaposi's sarcoma in the Israeli Jewish population between 1960 and 1998

et al. 2003

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Risk Factors for Classical Kaposi's Sarcoma

Abstract: Risk for classical KS was approximately fourfold lower in cigarette smokers, a result that requires confirmation by other studies. Identification of how smoking affects KS risk may lead to a better understanding of the pathogenesis of this malignancy and interventions for its prevention.

Cited by 112 publications

References 38 publications

Cause-specific mortality in classic Kaposi's sarcoma: a population-based study in Italy (1995–2002)

Cause-specific mortality in classic Kaposi's sarcoma: a population-based study in Italy (1995–2002)

A Common Genetic Variant inFCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma

Epidemiology of classic Kaposi's sarcoma in the Israeli Jewish population between 1960 and 1998

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