Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: a multicenter study

Wu, Xian; Zheng, Xiao; Huang, Yan; Cao, Qian; Zhang, Hongjie; Miao, Yinghui; Zou, Kai Fang; Chen, Min; Zhang, Faming; Qiao, Mu; Gonzálo, David; Allende, Daniela S.; Hu, Pin Jin; Shen, Bo; Liu, Xiu Li; Lan, Ping

doi:10.1093/gastro/goy039

Cited by 8 publications

(7 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammatory bowel disease (IBD) is also associated with an increased risk of CRC and the risk is higher when the history of IBD is longer [ 56 ]. However, it only explains ∼1% of all CRC in Western populations.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal cancers in China, the USA, and Europe

Xie

Shi

et al. 2021

Gastroenterology Report

146

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers, including colorectal cancer, gastric cancer, and esophageal cancer, are a major medical and economic burden worldwide and have the largest number of new cancer cases and cancer deaths each year. Esophageal and gastric cancers are most common in developing countries, while colorectal cancer forms the major GI malignancy in Western countries. However, a great shift in the predominant GI-cancer type is happening in countries under economically transitioning and, at the same time, esophageal and gastric cancers are reigniting in Western countries due to the higher exposure to certain risk factors. The development of all GI cancers is highly associated with lifestyle habits and all can be detected by identified precancerous diseases. Thus, they are all suitable for cancer screening. Here, we review the epidemiological status of GI cancers in China, the USA, and Europe; the major risk factors and their distribution in these regions; and the current screening strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Gastrointestinal cancers in China, the USA, and Europe

Xie

Shi

et al. 2021

Gastroenterology Report

146

View full text Add to dashboard Cite

show abstract

“…108 Moreover, there are few data on IBD-related CRN in non-Western populations, and, although recent data from China suggests similar risk factors for the development of CRN in Western populations, future investigations are required to reveal major population differences in risk factors for IBD-related CRN. 109 While there have been dramatic improvements in the prevention, identification, and management of colorectal neoplasia in IBD, there are several areas requiring further study. These areas include (a) increasing adherence to recommended quality metrics and surveillance practices; (b) appropriate surveillance intervals tailored to individual patient characteristics and updated to reflect current evidence supporting (cumulative inflammatory burden) or refuting (pseudopolyps) risk determinants; (c) noninvasive biomarker development to complement endoscopy; and (d) efforts to reduce barriers to surveillance, including safely lengthening intervals in those at lowest risk.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and management of inflammatory bowel disease-associated neoplasia: considerations in the modern era

Axelrad

Shah

2020

Therap Adv Gastroenterol

View full text Add to dashboard Cite

Patients with inflammatory bowel disease (IBD) are at an increased risk of developing intestinal neoplasia—particularly colorectal neoplasia, including dysplasia and colorectal cancer (CRC)—as a primary consequence of chronic inflammation. While the current incidence of CRC in IBD is lower compared with prior decades, due, in large part, to more effective therapies and improved colonoscopic technologies, CRC still accounts for a significant proportion of IBD-related deaths. The focus of this review is on the pathogenesis; epidemiology, including disease- and patient-related risk factors; diagnosis; surveillance; and management of IBD-associated neoplasia.

show abstract

“…The identification of dysplastic changes is important as this is an important stage in the development of cancer and considered a strong predictor of CRC in IBD. Chronic intestinal inflammation is the primary risk factor that leads to LGD, which can then progress to HGD and eventually CRC[ 54 ] (Figure 4 ). This sequence of events is thought to be accelerated in IBD-CRC compared to sporadic CRC[ 54 ].…”

Section: Pathogenesis Of Crc In Ibdmentioning

confidence: 99%

“…Chronic intestinal inflammation is the primary risk factor that leads to LGD, which can then progress to HGD and eventually CRC[ 54 ] (Figure 4 ). This sequence of events is thought to be accelerated in IBD-CRC compared to sporadic CRC[ 54 ]. In a study de Jong et al [ 55 ] investigated the long-term risk of HGD and CRC following the development of LGD using a nationwide database identifying a large IBD patient cohort.…”

Section: Pathogenesis Of Crc In Ibdmentioning

confidence: 99%

Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives

Majumder¹,

Shivaji²,

Kasturi³

et al. 2022

WJGO

View full text Add to dashboard Cite

Inflammatory bowel disease-related colorectal cancer (IBD-CRC) is one of the most serious complications of IBD contributing to significant mortality in this cohort of patients. IBD is often associated with diet and lifestyle-related gut microbial dysbiosis, the interaction of genetic and environmental factors, leading to chronic gut inflammation. According to the “common ground hypothesis”, microbial dysbiosis and intestinal barrier impairment are at the core of the chronic inflammatory process associated with IBD-CRC. Among the many underlying factors known to increase the risk of IBD-CRC, perhaps the most important factor is chronic persistent inflammation. The persistent inflammation in the colon results in increased proliferation of cells necessary for repair but this also increases the risk of dysplastic changes due to chromosomal and microsatellite instability. Multiple pathways have been identified, regulated by many positive and negative factors involved in the development of cancer, which in this case follows the ‘inflammation-dysplasia-carcinoma’ sequence. Strategies to lower this risk are extremely important to reduce morbidity and mortality due to IBD-CRC, among which colonoscopic surveillance is the most widely accepted and implemented modality, forming part of many national and international guidelines. However, the effectiveness of surveillance in IBD has been a topic of much debate in recent years for multiple reasons — cost-benefit to health systems, resource requirements, and also because of studies showing conflicting long-term data. Our review provides a comprehensive overview of past, present, and future perspectives of IBD-CRC. We explore and analyse evidence from studies over decades and current best practices followed globally. In the future directions section, we cover emerging novel endoscopic techniques and artificial intelligence that could play an important role in managing the risk of IBD-CRC.

show abstract

Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: a multicenter study

Cited by 8 publications

References 51 publications

Gastrointestinal cancers in China, the USA, and Europe

Gastrointestinal cancers in China, the USA, and Europe

Diagnosis and management of inflammatory bowel disease-associated neoplasia: considerations in the modern era

Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives

Contact Info

Product

Resources

About