Risk factors for delayed graft function after renal transplantation and their significance for long-term clinical outcome

Abstract

Delayed graft function (DGF) remains a grieving complication after renal transplantation. In this study, we examined various factors related to organ donation, transport, and transplantation for their influence on the incidence of DGF and on long-term prognosis.

Multicenter Analysis of Kidney Preservation

“…However, the definition of delayed graft function is poorly standardized (2) and, not surprisingly therefore, reports on the relevance of delayed graft function for graft survival varied considerably (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). We decided at the outset of this study that delayed graft function was an unsuitable factor for inclusion in this international database and relied on the graft survival rate as an objective measure of transplant outcome.…”

UW is Superior Compared with HTK After Prolonged Preservation of Renal Grafts

“…Flushing organ allografts with cold preservation solution rapidly reduces organ temperature and subsequently lowers metabolic rate and requirement for oxygen [1]. Yet, prolonged cold storage is associated with functional deterioration and poor graft outcome, as a consequence of tissue necrosis or apoptosis during organ preservation and reperfusion [2][3][4][5][6][7]. In addition, cold storage may impair the endothelial barrier function, resulting in parenchymal edema and hemorrhage [8].…”

Protective Effects of Peroxisome Proliferator-Activated Receptor γ Ligand on Apoptosis and Hepatocyte Growth Factor Induction in Renal Ischemia-Reperfusion Injury

“…In particular, the initial ischemia-reperfusion injury may affect the long-term outcome of renal allografts (2). A number of mechanisms of ischemia-reperfusion injury have been elucidated, with evidence indicating that apoptosis is a contributing factor such that inhibition of apoptosis ameliorates renal ischemia-reperfusion injury (3,4).…”