Risk Factors for Developing Glaucoma Among Patients With Uveitis

Hwang, De‐Kuang; Chou, Yiing Jenq; Pu, Cheng Yun; Chou, Pesus

doi:10.1097/01.ijg.0000435774.97407.67

Cited by 18 publications

(17 citation statements)

References 30 publications

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“…A Taiwanese study also found that increasing age was a significant risk factor for the development of OHT at initial uveitis presentation; however, that study reported that increasing age was only significant in the adult age group (17–64 years), but not in the elderly (>64 years). 10 That study also found that having anterior uveitis was a significant risk factor for the development of OHT, a finding echoed in the current study and in some previous reports, 1 but not others. 4 , 11 In our cohort, for each additional 0.5 logMAR increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P =0.047).…”

Section: Discussionsupporting

confidence: 85%

Ocular hypertension and hypotony as determinates of outcomes in uveitis

Aman

Engelhard

Bajwa

et al. 2015

OPTH

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PurposeTo assess ocular hypertension (OHT) and hypotony as outcomes of uveitis in patients managed in a mid-Atlantic tertiary care center.MethodsRetrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014.ResultsA total of 442 patients (582 eyes) with uveitis were identified and included in the study. The patient population was 57.0% female. Overall, 61.9% were Caucasian and 26.6% were African American. Mean age was 46.8 years. Overall, 11.5% of the eyes had OHT at initial visit, and 7.9% had OHT at final visit (P=0.035). For each additional decade of life, the odds that an eye had OHT were elevated by a factor of 1.15 (95% confidence interval [CI]: [1.02, 1.30], P=0.027) at initial visit and by a factor of 1.15 (95% CI: [1.00, 1.32], P=0.055) at final visit. The odds that an anterior uveitis eye had OHT were greater by a factor of 2.50 (95% CI: [1.22, 5.14], P=0.013) than the odds for a nonanterior uveitis eye at initial visit and greater by a factor of 2.61 (95% CI: [1.24, 5.50], P=0.011) at final visit. For each additional 0.5 logarithm of the minimum angle of resolution increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P=0.047) at initial visit and 1.23 (95% CI: [0.99, 1.54], P=0.065) at final visit. Overall, 21 of 582 eyes (3.6%) were hypotonous initially, while 24 of 582 eyes (4.1%) were hypotonous at final follow-up (P=0.631).ConclusionOHT was associated with increasing age, anterior uveitis, and poor presenting visual acuity. Ocular hypotony was more common in anterior uveitis than in nonanterior uveitis. Fluctuations in intraocular pressure are an important cause of visual impairment in patients with uveitis. Careful monitoring of all uveitis patients, and especially those most at risk for fluctuations in intraocular pressure, can preserve vision and improve patient outcomes.

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Section: Discussionsupporting

confidence: 85%

Ocular hypertension and hypotony as determinates of outcomes in uveitis

Aman

Engelhard

Bajwa

et al. 2015

OPTH

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“…Glaucoma was proven to be associated with certain types of uveitis, with a significant difference from preceding articles. 5,13,32 Moreover, cataracts also occurred more commonly in individuals with chronic forms of uveitis. 5 Because antiglaucoma medication and DED would impair the ocular surface and cornea, [33][34][35] the higher disease numbers in the study group may disturb the effect of uveitis on keratopathy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Nien

Lee

Chao

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. METHODS. Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four nonuveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. RESULTS. A total of 4773 uveitis patients (2662 male and 2111 female) and 19,092 non-uveitis patients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR ¼ 1.765) and panuveitis (aHR ¼ 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. CONCLUSIONS. The presence of uveitis significantly elevates the risk for developing keratopathy.

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“…In a report by Hwang et al 13 from Taiwan, the risk factors for OHT or glaucoma at the time of uveitis development included male, 17–64 years of age, and anterior uveitis. Although we did not separate patients in whom OHT was observed when uveitis occurred from all uveitic patients with OHT, the prevalence of eyes with OHT in male uveitic patients was significantly higher than that in female patients (31.0% vs 21.6%).…”

Section: Discussionmentioning

confidence: 99%