Risk Factors For Diabetic Retinopathy Progression

Deák, Mónika; Lasca, Monica; Vereşiu, Ioan Andrei

doi:10.1515/rjdnmd-2015-0020

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…15 Meanwhile, age above 50 years and a history of metabolic syndrome have been reported as one risk factors in the development of DM and PDR. 16 The mean value of TGF-β1 levels in patients with or without PRP laser therapy using a vitreous sample was 3,692.86 ± 333.89 pg/ml, while the mean serum level was 12,821.43 ± 5,25pg/ml (Table 1). However, after treatment (Table 2), the vitreous TGF-β1 level in the group treated with laser therapy showed lower values than patients who did not receive PRP laser therapy.…”

Section: Processing and Data Analysismentioning

confidence: 95%

Comparison of serum and vitreous TGF-β1 levels in proliferative diabetic retinopathy with and without panretinal photocoagulation laser therapy

et al. 2022

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Introduction: A long-term diabetic retinopathy will cause an increase in several growth factors expression like Transforming Growth Factor β (TGF-β). This multipotent cytokine is involved in the process of endothelial cell proliferation. Therefore, this study aims to observe the relationship between TGF-β1 levels in serum and vitreous fluid of Proliferative Diabetic Retinopathy (PDR) patients given Pan Retinal Photocoagulation (PRP) laser therapy. Method: This was a cross-sectional study involving 14 patients with PDR. TGF-β1 levels of vitreous and peripheral blood were measured using Enzyme-linked Immunosorbent Assay (ELISA) method. The data were statistically analyzed using SPSS software for Windows ver. 23.0 for Mann-Whitney and the Spearman correlation test. Results: Our subjects consisted of 57.1% males with a mean age of 51.8 years, where dyslipidemia was the most common comorbid disease. Mean serum TGF-β1 level was 12,821.43 ± 5,253.16 pg/ml, while the mean value in vitreous was 3,692.86 ± 333.89 pg/ml. Meanwhile, there was no significant difference in serum and vitreous TGF-β1 levels between subjects with and without PRP laser therapy (p>0.05). Conclusion: There was no significant correlation between TGF-β1 levels in proliferative diabetic retinopathy patients with and without panretinal photocoagulation laser therapy. However, there was a decreasing trend in TGF-β1 levels in the vitreous fluid, indicating that PRP laser therapy has a positive effect on preventing the formation of neovascularization in the eye.

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Section: Processing and Data Analysismentioning

confidence: 95%

Comparison of serum and vitreous TGF-β1 levels in proliferative diabetic retinopathy with and without panretinal photocoagulation laser therapy

et al. 2022

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“…Numerous empirical studies have been conducted to identify risk factors associated with the development and severity of DR. Comorbidities such as impaired renal function, uncontrolled T2DM, hypertension, and dyslipidemia have been shown to be prevalent among individuals with proliferative diabetic retinopathy. [8,9] However, many of these studies did not specifically investigate factors associated with the progression of DR, as they did not segregate subjects based on the stage of diabetic retinopathy for comparison of risk factors among them. To address this gap in the literature, the present study aims to investigate the significant association between various cardiac and renal risk factors, namely age, gender, duration of diabetes, history of ischemic heart disease, hypertension, serum levels of urea, creatinine, cholesterol, and triglycerides, and the progression of NPDR into PDR.…”

Section: Introductionmentioning

confidence: 99%

Study on Risk Factors Associated with Severity of Diabetic Retinopathy in Type-2 Diabetic Patients, Attending a Tertiary Care Centre in Kerala

Varma,

Thulaseedharan

2023

Int J Res Rev

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Introduction: Diabetic retinopathy (DR) is a significant public health concern affecting individuals with diabetes mellitus (DM). Despite treatment advances, a substantial proportion of patients do not respond adequately. This study investigates risk factors associated with the progression of non-proliferative diabetic retinopathy (NPDR) to proliferative diabetic retinopathy (PDR) in type-2 diabetes patients. Methods: A retrospective case-control study was conducted on diabetic patients older than 40 years with at least 5 years of Type-2 Diabetes Mellitus history, attending ophthalmology clinic in Government Medical College, Thrissur, a tertiary care hospital. Data from patients with retinal examination showing diabetic retinopathy were analyzed. Records with missing data were excluded. Patients with Proliferative Diabetic Retinopathy (n=153) were compared with those having Non- Proliferative Diabetic Retinopathy (n=230). Various risk factors were assessed using statistical analysis. Results: Among the studied variables, sex, duration of diabetes, serum urea, serum creatinine, serum triglycerides, and chronic kidney disease were significantly different between Proliferative Diabetic Retinopathy and Non-Proliferative Diabetic Retinopathy patients. Binary logistic regression revealed that duration of diabetes (OR = 1.8, 95% CI = 1.1 - 2.39) and serum creatinine (OR =1.8, 95% CI = 1.1 - 2.39) independently influenced Proliferative Diabetic Retinopathy development. Conclusion: This study highlights that longer diabetes duration and elevated serum creatinine levels independently increase the risk of Non- Proliferative Diabetic Retinopathy progressing to Proliferative Diabetic Retinopathy in type-2 diabetic patients. Other factors such as age, gender, hyperlipidemia, systemic hypertension, type of diabetic treatment, and history of ischemic heart disease did not show significant associations with disease progression. These findings emphasize the importance of close monitoring, early detection, and intervention in patients with Non- Proliferative Diabetic Retinopathy, particularly those with a longer diabetic history, to prevent Proliferative Diabetic Retinopathy development. Further research should explore the causal relationship between serum creatinine and diabetic retinopathy progression and evaluate the impact of renal disease management on disease outcomes. Keywords: Diabetic Retinopathy, diabetes mellitus (DM), Type-2 Diabetes Mellitus (T2DM).

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Risk Factors For Diabetic Retinopathy Progression

Abstract: Background and Aims. There is no unanimous opinion regarding the risk factors associated with progression of diabetic retinopathy (DR

Cited by 2 publications

References 8 publications

Comparison of serum and vitreous TGF-β1 levels in proliferative diabetic retinopathy with and without panretinal photocoagulation laser therapy

Comparison of serum and vitreous TGF-β1 levels in proliferative diabetic retinopathy with and without panretinal photocoagulation laser therapy

Study on Risk Factors Associated with Severity of Diabetic Retinopathy in Type-2 Diabetic Patients, Attending a Tertiary Care Centre in Kerala

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