Risk Factors for Gallstone Disease in a Hospital-Based Study

Lai, Shih‐Wei; Ng, Kim-Choy

doi:10.1097/00007611-200212000-00013

Cited by 19 publications

(25 citation statements)

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“…In a retrospective review of 1,028 subjects undergoing a periodic health examination at China Medical College Hospital in Taiwan, multivariate analysis identified HCV infection as a risk factor for GBD in women (OR ϭ 3.6; 95% CI, 1.4-9.7) but not men. 42 In contrast, a retrospective study by O'Sullivan et al 43 found that the incidence of gallstones in 318 patients infected with HCV was no different than the incidence of gallstones in the general population in Ireland.…”

Section: Discussionmentioning

confidence: 91%

Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States†

Bini¹,

McGready²

2005

Hepatology

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Although cirrhosis is a known risk factor for gallstones, little is known about gallbladder disease (GBD) in individuals with hepatitis C virus (HCV) infection. We determined the association between chronic HCV infection and GBD in a representative sample of adults in the United States. Data on HCV infection and GBD were available for 13,465 persons 20 to 74 years of age who participated in the Third National Health and Nutrition Examination Survey. The presence of GBD (gallstones or cholecystectomy) was determined using abdominal ultrasonography, and HCV infection was assessed via a positive HCV antibody test and a positive HCV RNA test. Overall, 1.6% of adults (95% CI, 1.1-2.1) had chronic HCV infection and 12.5% (95% CI, 11.3-13.7) had GBD. After adjusting for potential confounding variables, the odds of gallstones (OR ‫؍‬ 3.20; 95% CI, 1.08-9.45) and cholecystectomy (OR ‫؍‬ 4.57; 95% CI, 1.57-13.27) among HCV-positive men was significantly higher compared with HCV-negative men. In contrast, the adjusted odds of gallstones (OR ‫؍‬ 2.55; 95% CI, 0.58-11.25) and cholecystectomy (OR ‫؍‬ 0.70; 95% CI, 0.21-2.37) among HCV-positive women was not significantly higher. The odds of GBD increased significantly with the severity of liver disease as assessed via elevated serum bilirubin levels and low levels of serum albumin and platelets. In conclusion, chronic HCV infection was strongly associated with GBD among men but not women in the United States, and GBD was more common in adults with severe liver disease. (HEPATOLOGY 2005;41:1029-1036

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Section: Discussionmentioning

confidence: 91%

Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States†

Bini¹,

McGready²

2005

Hepatology

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“…Chronic hepatic inflammation has been recognized as one of the causes of GB stone formation [1]. Increased prevalence of GB stones has been reported in patients with chronic HCV infection [5,19].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonography (US) is a noninvasive tool for evaluating disorders of the internal organs. Because of its extensive application in the clinical diagnosis of abdominal diseases, diagnosis of gallbladder (GB) stones and polyps is common in US examinations [1,2]. The criteria for diagnosing GB stones are the presence of echogenic densities casting distal acoustic shadow or mobility upon postural change with or without distal acoustic shadow [3,4].…”

Section: Introductionmentioning

confidence: 99%

Association between gallbladder stones and chronic hepatitis C: Ultrasonographic survey in a hepatitis C and B hyperendemic township in Taiwan

Dai

Lin

Yeh

et al. 2013

The Kaohsiung J of Med Scie

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Gallbladder (GB) stones have been associated with several metabolic factors and liver diseases. This community-based study aimed at investigating the prevalence rate of GB stones and its associated factors in a hepatitis B virus (HBV)/hepatitis C virus (HCV)-endemic township in southern Taiwan. A total of 1701 residents (689 males and 1012 females; mean age: 51.2 ± 16.0 years) were enrolled in this prospectively designed screening project. Serum biochemistry tests, including testing for levels of serum aspartate aminotransferase, alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), and antibody to HCV (anti-HCV) were conducted. In addition, a hepatobiliary ultrasonographic (US) examination was also conducted. Of the 1701 residents, 243 (14.3%) and 475 (27.9%) were found to be positive for HBsAg and anti-HCV, respectively. Results of the US examination revealed the prevalence rate of GB stone and fatty liver to be 6.8% and 55.6%, respectively. Using univariate analyses we found that significantly higher proportions of the participants with GB stone were male, over 50 years of age, positive for anti-HCV (p = 0.001, p < 0.001, and p = 0.001, respectively), with significantly higher mean age and ALT level (p ≤ 0.001 and p = 0.048, respectively) than did those without GB stone. By applying multivariate analyses, male gender, positive anti-HCV, and older age (>50 year) were identified as independent factors associated with the formation of GB stones. Anti-HCV was associated with GB stones in males but not in females in both univariate and multivariate analyses. GB stones were found to have a prevalence rate of 6.8% in this HCV/HBV hyperendemic township and are associated with higher mean age. A correlation between chronic hepatitis C and GB stones is observed only among males.

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“…The risk of gallstone disease is greater in women than in men at all ages in the majority of studies 2 . Exceptions are studies from Taiwan reporting no statistical significance in the prevalence of cholelithiasis among males and females [12][13][14] . The more commonly found pigment stones in that population have been offered as a possible reason for this exception.…”

Section: Sexmentioning

confidence: 95%

Prevalence of cholelithiasis among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.

Gyedu¹,

Adae-Aboagye²,

Badu-Peprah³

2015

Afr H. Sci.

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Background: The prevalence of gallstones among Ghanaians is unknown. We aimed to determine the prevalence of gallstones among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital (KATH). Methods: We performed a cross-sectional study of patients aged ≥14years presenting to KATH for abdominal ultrasound between 2009 and 2012. Patient demographics were recorded. The gallbladder was assessed by ultrasonography. Cholelithiasis was defined as presence of gallstones or absence of gallbladder. Data was expressed as descriptive and inferential statistics. Results: There were 2824 participants. 55% were females. Mean age was 47±18 years. Mean body mass index (BMI) was 24.0±5.5. Mean parity among females was 3±3. Prevalence of cholelithiasis was 5.9 (95%C.I:5.0,6.8). Females had a high prevalence compared to males (6.8 vs 4.7). Prevalence increased steadily by age. Prevalence was 6.6, 5.1 and 8.8 for patients with BMI <18.5, 18.5-24.9 and ≥30 respectively. Prevalence among women with parity of 0,1-5 and >5 was 3.1, 6.7 and 6.4 respectively.On multivariate regression analysis, female sex (AOR=1.55;p<0.05), age≥40 years (AOR=2.05;p<0.01), BMI<18.5 (AOR=1.25;p>0.05) or BMI≥30 (AOR=1.39;p>0.05) and family history of gallstones (AOR=11.9;p<0.01) increased the odds of cholelithiasis. Conclusions: Prevalence of cholelithiasis among patients undergoing ultrasonography at KATH was 5.9. Patient age, sex and family history significantly influenced the prevalence.

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Risk Factors for Gallstone Disease in a Hospital-Based Study

Cited by 19 publications

References 0 publications

Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States†

Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States†

Association between gallbladder stones and chronic hepatitis C: Ultrasonographic survey in a hepatitis C and B hyperendemic township in Taiwan

Prevalence of cholelithiasis among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.

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