Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Toporcov, Tatiana Natasha; Znaor, Ariana; Zhang, Zuo‐Feng; Gao, Yu; Winn, Deborah M.; Wei, Qingyi; Vilensky, Marta; Vaughan, Thomas L.; Thomson, Peter; Talamini, Renato; Szeszenia-Da̧browska, Neonila; Sturgis, Erich M.; Smith, Elaine; Shangina, Oxana; Schwartz, Stephen M.; Schantz, Stimson P.; Rudnai, Péter; Richiardi, Lorenzo; Ramroth, Heribert; Purdue, Mark P.; Olshan, Andrew F.; Eluf-Neto, José; Muscat, Joshua E.; Moysés, Raquel Ajub; Morgenstern, Hal; Menezes, Ana; McClean, Michael D.; Matsuo, Keitaro; Mateș, Dana; Macfarlane, Tatiana V.; Lissowska, Jolanta; Levi, Fabio; Lazarus, Philip; Vecchia, Carlo La; Λάγιου, Παγώνα; Koifman, Sérgio; Kjærheim, Kristina; Kelsey, Karl T.; Holcátová, Ivana; Herrero, Rolando; Healy, Claire M.; Hayes, Richard B.; Franceschi, Silvia; Fernández, Leticia; Fabiánovà, Eleonóra; Daudt, Alexander W.; Curioni, O A; Maso, Luigino Dal; Curado, María Paula; Conway, David I.; Chen, Chu; Castellsagué, Xavier; Canova, Cristina; Cadoni, Gabriella; Brennan, Paul; Boccia, Stefania; Antunes, José Leopoldo Ferreira; Ahrens, Wolfgang; Agudo, Antonio; Boffetta, Paolo; Hashibe, Mia; Lee, Yuan Chin Amy; Filho, Victor WÃ1⁄4nsch

doi:10.1093/ije/dyu255

Cited by 142 publications

(148 citation statements)

References 62 publications

(103 reference statements)

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“…Interestingly, the relative proportion of OSCC and OPSCC in young patients revealed a significant difference between North America (5.5%) and both Africa (17.2%) and the Middle East (14.5%). Taken together, there seems to be a rising trend in the incidence of OSCC and OPSCC among young patients worldwide [6]. …”

Section: Epidemiology Of Hnsccsmentioning

confidence: 99%

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

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Background: The association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSCC) was first described in 1982–1983 by the authors of this review. Prompted by this discovery 35 years ago, an entirely new field of HPV research has emerged, resulting in a paradigm shift from smoking and alcohol as the only etiological factors to confirmation of HNSCC as an important group of HPV-related human malignancies. Summary: In this review, the authors first describe the scope (i.e., HNSCC) by the anatomic sites of the tumors. Their important site-specific differences in epidemiology are emphasized, and the misconceptions caused by the adopted practice of pooling all tumors from these divergent anatomic sites as a single entity (HNSCC) are pinpointed. The convincing evidence of the established risk factors (smoking and alcohol) is briefly addressed, before entering in the discussion on the causal role of HPV in HNSCC pathogenesis. The global HPV prevalence in different subsets of HNSCC is summarized using the data extracted from all meta-analyses published since 2010. Of all HNSCC subsets, oropharyngeal SCC has an HPV profile distinct form all the other subsets, and the possible mechanisms explaining this intimate association with HPV are discussed. Key Messages: Recent global trends show a constant increase in HNSCC rates particularly among younger age groups. The evidence on cigarette smoking and alcohol consumption as the prime risk factors of HNSCC is overwhelming. During the past 35 years, however, increasing evidence has accumulated implicating an important causal role of HPV in HNSCC. These data have important clinical implications, HPV detection and tailored treatment strategies for HPV-positive HNSCCs currently being an integral part of the oncological management practices of HNSCC.

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Section: Epidemiology Of Hnsccsmentioning

confidence: 99%

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

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“…Several studies have shown a high rate of occult nodal metastasis (20-40%) in tongue SCC patients with no evidence of regional spread on clinical or radiographic evaluation (8,(10)(11)(12)(13)(14)(15). There is a tendency that tongue cancer increases in young females in recent 2-3 decades (16)(17)(18). Thus, metastasis suppression is a main and urgent subject in the treatments of patients with tongue SCC.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis

Tanaka

Imamura

Yoneda

et al. 2016

International Journal of Oncology

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Abstract.To study the role of TNF-α in tongue cancer metastasis, we made highly metastatic cells from a human oral squamous cell carcinoma cell line (SAS) by repeating the passage in which the cells were injected into a nude mouse tongue and harvested from metastasized cervical lymph nodes. Cancer cells after 5 passages (GSAS/N5) increased invasive activity 7-fold in a TNF-α receptor 1 (TNFR1)-dependent manner and enhanced mRNA expression of TNF-α and TNFR1. In the highly metastatic cells, NF-κB activation was upregulated via elevated phosphorylation of Akt and Ikkα/β in the signaling pathway and secretion of TNF-α, active MMP-2 and MMP-9 increased. Suppression of increase of TNF-α mRNA expression and MMP secretion by NF-κB inhibitor NBD peptide suggested a positive feedback loop in GSAS/N5 cells; TNF-α activates NF-κB and activated NF-κB induces further TNF-α secretion, leading to increase of active MMP release and promotion of invasion and metastasis of the cells. GSAS/N5 cells that had been injected into the nude mouse tongue and harvested from metastasized lungs multiplied angiopoietin-like 4 (Angptl4) expression with enhanced migration activity, which indicated a possible involvement of Angptl4 in lung metastasis of the cells. These results suggest that TNF-α and Angptl4 promote metastasis of the oral cancer cells, thus, these molecules may be therapeutic targets for patients with tongue cancer. IntroductionThe American Cancer Society estimated 45,780 new cases of oral cavity and pharyngeal cancer, and 8,650 deaths from these tumors, in 2015 in the United States (1). By advances in surgery and radiation therapy, the 5-year survival rate for oropharyngeal cancer has increased to 66%, but the rate is still unsatisfactory in comparison with some other site cancers including prostate, thyroid and breast; the rates of these types of cancer are >90% (1). A primary cause for the unfavorable prognosis is patient death from the cancer metastasized at regional and distant sites (2-5). Squamous cell carcinoma (SCC) accounts for approximately 90% of oral and oropharyngeal malignancies in the United States and tongue is a common site of the malignant diseases (6,7). The rate of nodal metastasis is higher in tongue cancer patients than oral cavity cancer patients whose rate is 30% on their initial evaluation (8,9). Several studies have shown a high rate of occult nodal metastasis (20-40%) in tongue SCC patients with no evidence of regional spread on clinical or radiographic evaluation (8,10-15). There is a tendency that tongue cancer increases in young females in recent 2-3 decades (16-18). Thus, metastasis suppression is a main and urgent subject in the treatments of patients with tongue SCC.The process of metastasis is complex and involves tumor growth, the extra-cellular matrix breakdown, invasion to the vessels, escape from immune surveillance, transport to other sites with adhesion to the vessel, subsequent invasion into an organ where tumor cells proliferate, grow and spread. Various molecules participate in the pr...

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“…The most relevant risk factors are smoking, air pollutants, chronic alcohol consumption, biological agents, and particularly human papillomavirus infection. 2,3 Nowadays, conventional treatment strategies for oral cancer involve surgical treatment, radiation therapy, and chemotherapy, administered alone or in different combinations. Chemotherapeutic agents used for oral cancer treatment are doxorubicin (Dox) or cisplatin.…”

Section: Introductionmentioning

confidence: 99%

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Irimie

Sonea²,

Jurj

et al. 2017

IJN

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Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed.

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Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Cited by 142 publications

References 62 publications

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

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