Risk Factors for Health Care–Associated Sepsis in Critically Ill Neonates Stratified by Birth Weight

Verstraete, Evelien; Coen, Kris De; Vogelaers, Dirk; Blot, Stijn

doi:10.1097/inf.0000000000000851

Cited by 16 publications

(7 citation statements)

References 39 publications

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“…During 2013-2017, Gram-positive bacteria, in particular CONS (25.3%) and S. aureus (2.3%), were the most frequent pathogens responsible for CLABSIs. This finding is in accordance with several reports showing that grampositive bacteria are the main cause of bloodstream infections in neonates in the NICUs [4,12,17,[28][29][30]. Other most frequent pathogens responsible for CLABSIs in the NICU were Candida spp., C. parapsilosis (21.8%) and C. albicans (4.6%), P. aeruginosa (5.7%), E. coli (3.4%) and K. pneumoniae (3.4%).…”

Section: Discussionsupporting

confidence: 92%

“…This finding is in agreement with previous studies showing that bloodstream infections prevailed among HAIs in Italian NICUs [16,17] and that bloodstream infections were the main infections (45,4%), followed by lower respiratory tract infections (27.8%) and urinary tract infections (15.8%) in Italian and Brazilian PICUs and NICUs [19]. High percentage of bloodstream infections in NICUs has been also reported by NHSN in USA [4], neonINnetwork in UK [12] and worldwide [28][29][30][31]. Finally, the increase of CLABSI incidence density during 2013-2017 in our NICU is alarming because CLABSI rates measure Hospital performance for high-quality patient care [32].…”

Section: Discussionsupporting

confidence: 92%

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Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017

et al. 2020

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Background: Healthcare-associated infections (HAIs) occur frequently in intensive care units (NICUs). The aim of this study was to analyze the results of surveillance of HAIs in a III level NICU in Naples, Italy during 2013-2017 and to compare with those obtained during 2006-2010. Methods:The surveillance included 1265 neonates of all birth weight (BW) classes with > 2 days NICU stay. Infections were defined using standard Centers for Disease Control and Prevention definitions adapted to neonatal pathology.Results: A total of 125 HAIs were registered during 2013-2017 with a frequency of 9.9% and an incidence density of 3.2 per 1000 patient days. HAIs occurred in all BW classes with a decreasing trend from the lowest to the highest BW classes (p = < 0.001). Central line-associated blood stream infection (CLABSI) was the most frequent infection (69.6%), followed by ventilator associated pneumonia (VAP) (20%), urinary tract infection (UTI) (8.8%) and necrotizing enterocolitis (NEC) (1.6%). Also, CLABSI and VAP incidence density decreased from lower to highest BW classes showing a significant trend (p = 0.007). Most frequent pathogens responsible for CLABSI were: Coagulase-negative staphylococci (CONS) (25.3%), Candida parapsilosis (21.8%), Pseudomonas aeruginosa (5.7), Escherichia coli and Klebsiella pneumoniae (6.8%). No microbiological diagnosis was achieved for 20.7% of CLABSI. Pseudomonas aeruginosa (28%), Stenotrophomonas maltophilia (20%), and CONS (20%) were the most frequent pathogens responsible for VAP. CLABSI incidence density showed no differences between 2006 and 2010 and 2013-2017, while VAP incidence density for the 751-100 g BW class was higher during 2006-2010 than during 2013-2017 (p = 0.006). A higher incidence of the CLABSI caused by Gram positive bacteria (p = 0.002) or by undetermined etiology (p = 0.01) was observed during 2013-2017 than during 2006-2010, while a significant lower incidence of VAP caused by Gram-negative bacteria was found during

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017

et al. 2020

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“…Os estudos nacionais publicados mostram que essas infecções estão relacionadas com o peso ao nascimento, a utilização de cateter venoso central (CVC) e com o tempo de ventilação mecânica (2) . Nesse sentido, a investigação dos fatores de risco para a sepse neonatal é importante na implementação de medidas que qualifiquem a assistência prestada ao RN, e principalmente, a prevenção de riscos relativos à exposição a agentes patogênicos causadores da sepse (3) .…”

Section: Introductionunclassified

Fatores De Risco Para Sepse Neonatal Em Unidade De Terapia: Estudo De Evidência

et al. 2016

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RESUMEN: Revisión integrativa de literatura cuya finalidad fue presentar las principales evidencias de factores de riesgo para sepsis neonatal en recién nacidos internados en Unidad de Terapia Neonatal. La búsqueda fue hecha entre los meses de julio y agosto de 2015, en las bases de datos Scientific Eletronic Library Online, SciVerse Scopus y PubMed, utilizándose los descriptores: factores de riesgo, unidad de terapia intensiva neonatal, recién nacido; y las siguientes palabras claves: sepsis neonatal y prematuridad. La búsqueda totalizó 31 publicaciones cuyos resultados mostraron que los factores predictivos para sepsis neonatal están asociados a edad gestacional, ruptura prematura de las membranas amnióticas e infección materna. Condiciones de nacimiento, bajo peso y prematuridad son fuertes evidencias para sepsis. Los factores referentes al ambiente de la unidad de terapia intensiva neonatal contribuyen mucho para la sepsis tardía.

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“…Otros estudios tienen resultados similares como el desarrollado en Bélgica y publicado en el año 2015, donde se trabajó con 342 neonatos que sobrevivieron las primeras 72 horas después del nacimiento, y que fueron hospitalizados en la Unidad de Cuidados Críticos, se encontró que el riesgo de sepsis neonatal temprana aumenta conforme disminuye el peso al nacer 15 .…”

Section: Discussionunclassified

Factores de riesgo asociados a sepsis neonatal temprana en prematuros de un Hospital Nacional Docente Madre Niño, 2017

Burga-Montoya¹,

Luna-Muñoz

Correa-López

2019

RFMH

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Introducción: La sepsis neonatal es una de las enfermedades más importantes de nuestro País, es necesario conocer sus factores de riesgo. Objetivo: Determinar los factores asociados a sepsis neonatal temprana en prematuros del Hospital Nacional Docente Madre Niño San Bartolomé en el año 2017. Métodos: Estudio de casos y controles, observacional, analítico de corte transversal y retrospectivo. La población consta de 210 recién nacidos prematuros del Hospital Nacional Docente Madre Niño San Bartolomé, año 2017. La variable dependiente fue la sepsis neonatal temprana. Se trabajó con un tamaño muestral de 62 casos y 124 controles (ratio 1:2).Los datos se obtuvieron de las historias clínicas. Para la estadística inferencial se utilizó el análisis bivariado para hallar los Odds Ratio con sus respectivos intervalos de confianza al 95%. Se consideró p<0,05 como estadísticamente significativo.

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Risk Factors for Health Care–Associated Sepsis in Critically Ill Neonates Stratified by Birth Weight

Abstract: In our neonatal intensive care unit, risk stratification by birth weight revealed some difference. Special attention concerning infection control practices is for neonates receiving TPN, mechanical ventilation, cardiac surgery, and with a gastrointestinal disease.

Cited by 16 publications

References 39 publications

Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017

Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017

Fatores De Risco Para Sepse Neonatal Em Unidade De Terapia: Estudo De Evidência

Factores de riesgo asociados a sepsis neonatal temprana en prematuros de un Hospital Nacional Docente Madre Niño, 2017

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