Risk Factors for Hypoglycemia-Related Hospitalization in Patients With Type 2 Diabetes: A Nested Case–Control Study

Sulfonylurea monotherapy and emergency room utilization among elderly patients with type 2 diabetes

“…In addition, our finding related to documented hypoglycemia is consistent with existing studies suggesting an increased risk of hypoglycemia among patients using SUs [12,13] and studies suggesting an association between hypoglycemia and increased morbidity and mortality among patients with type 2 diabetes [14][15][16].…”

“…In an earlier study involving patients with type 2 diabetes taking OADs, patients with hypoglycemia were significantly older and had more comorbidities than controls [12]. Previous visits to ERs and offices for hypoglycemia were associated with significant, approximately 8-to 9-fold increased odds of hospitalizations for hypoglycemia.…”

A Patient-level Analysis of Efficacy and Hypoglycaemia Outcomes Across Treat-to-target Trials with Insulin Glargine Added to Oral Antidiabetes Agents in People with Type 2 Diabetes

“…These include younger age, lower BMI, previous hypoglycaemic events, presence of individual micro-and macrovascular complications, duration of diabetes, duration of insulin treatment, type of insulin and number of insulin injections. [32][33][34][35][36][37] Finally, and as shown in the current study, the type of OAD administered as background therapy and the characteristics of the patients administered these different combinations can also impact on the risk of hypoglycaemia.…”

Association Between Hypoglycemia and Fall-Related Events in Type 2 Diabetes Mellitus: Analysis of a U.S. Commercial Database

“…Continuous and intermittent sulfonylurea availability has also been reported as a predictor for hypoglycemia-related hospitalization. 25 A detailed understanding of sulfonylureas is a critical need, given that an estimated 50%-66% T2DM patients use sulfonylureas alone or in combination with other diabetes medications. 26 Physicians treating elderly diabetes patients need to make treatment decisions that minimize the risk of hypoglycemia thereby avoiding the ensuing complications of falls.…”