Risk Factors for Hypothermia in Psychiatric Patients

Young, Dykes M

doi:10.3109/10401239609148807

Cited by 36 publications

(40 citation statements)

References 17 publications

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“…Der Begriff der Hypothermie bezeichnet eine Erniedrigung der Körperkerntemperatur beim Menschen unter 35°C [2,39]. Es handelt sich um eine potenziell lebensbedrohliche unerwünschte Arzneimittelwirkung, die für einen Teil der nicht geklärten Todesfälle bei psychi atrischen Patienten mitverantwortlich sein könnte [28,39]. Häufiger als im Zusammenhang mit Arzneimittelgaben treten Hypothermien jedoch bei Unfällen in niedriger Umgebungstemperatur …”

Section: Diskussionunclassified

“…Entsprechend stellt der Aufenthalt in kühler Umgebung (z. B. klimatisierten Räumen) für antipsychotikaassoziierte Hypothermien einen weiteren bedeutsamen Risikofaktor dar [39].…”

Section: Risikofaktoren Für Antipsychotikaassoziierte Hypothermieunclassified

“…Als weitere Risikofaktoren für die Entwicklung einer Hypothermie in psychiatrischen Patientenpopulationen wurden nächtliche Enuresis, Epilepsie, gravierende somatische Komorbidität und Intelligenzminderung identifiziert [39]. Gerade bei vorliegenden Infektionen kann es im Rahmen einer Sepsis auch zu erniedrigten Körpertemperaturen kommen, was sich in den SIRS ("systemic inflammatory response syndrome") -Kriterien niederschlägt [38].…”

Section: Risikofaktoren Für Antipsychotikaassoziierte Hypothermieunclassified

“…Gerade bei vorliegenden Infektionen kann es im Rahmen einer Sepsis auch zu erniedrigten Körpertemperaturen kommen, was sich in den SIRS ("systemic inflammatory response syndrome") -Kriterien niederschlägt [38]. Das Hypothermierisiko nach Applikation antipsychotischer Substanzen wird weiter erhöht durch die Kombination von Antipsychotika mit β-Blockern, Benzodiazepinen und anderen Sedativa [39]. Als Erklärung könnte neben einem möglichen direkten Kausalzusammenhang die Vermutung herangezogen werden, dass schwerkranke Patienten, welche einer polypharmakologischen Behandlung bedürfen, aufgrund ihrer Komorbiditäten häufiger von antipsychotikaassoziierten Hypothermien betroffen sind.…”

Section: Risikofaktoren Für Antipsychotikaassoziierte Hypothermieunclassified

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Hypothermie unter Olanzapin

et al. 2011

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A review of the current literature reveals that thermoregulatory disturbances as sequelae of antipsychotic drug administration depend on individual disposition as well as various independent risk factors such as environmental temperature, somatic comorbidities, endocrinological abnormalities (e.g. hypothyroidism) and structural damage of the brain. A complex interaction of dopaminergic regulatory mechanisms in the ventral hypothalamus and peripheral vaso- and sudomotor adjustments seems to be causative. Hypothermia following antipsychotic drug administration represents a serious adverse drug reaction and a potentially life-threatening event.

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Section: Diskussionunclassified

“…Entsprechend stellt der Aufenthalt in kühler Umgebung (z. B. klimatisierten Räumen) für antipsychotikaassoziierte Hypothermien einen weiteren bedeutsamen Risikofaktor dar [39].…”

Section: Risikofaktoren Für Antipsychotikaassoziierte Hypothermieunclassified

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Hypothermie unter Olanzapin

et al. 2011

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“…The references cited in their communication are so important that they are listed again here. [6][7][8][9][10][11] According to his family, the patient presented here was not known to be taking any antipsychotic or neuroleptic drugs, and no pill bottles were found on his person or in his hotel room.…”

Section: Hypothermia Due To Neuroleptic Drugsmentioning

confidence: 99%

Osborn waves in the electrocardiogram, hypothermia not due to exposure, and death due to diabetic ketoacidosis

Sheikh

Hurst

2003

Clinical Cardiology

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Summary:Hypothermia usually occurs because a patient has been exposed to a cold environment; however, a number of nonenvironmental conditions may produce hypothermia. This report relates the clinical course of a patient whose hypothermia was due to severe diabetic ketoacidosis. In addition, we review the causes of hypothermia and Osborn waves beyond exposure to cold temperature. Hypothermia due to diabetic ketoacidosis is an uncommon complication of a common disease that carries with it clinically significant consequences. Accordingly, we believe that all clinicians should be aware of this potential complication of diabetic ketoacidosis and should be able to recognize the importance of the electrocardiogram in such patients.

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Characteristics of antipsychotic drug‐induced hypothermia in psychogeriatric inpatients

Kamp

Paschali

Bouanane

et al. 2021

Human Psychopharmacology

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Objective Hypothermia is a potentially lethal adverse reaction to typical and atypical antipsychotic drugs (APD). Among predisposing factors are advanced age and comorbid somatic diseases. The aim of this study was to assess the incidence of hypothermia and quantify risk factors. Method Charts of N = 3002 psychogeriatric inpatients were screened for incidence of hypothermia (body core temperature <35.0°C). The frequency of hypothermia was compared between patients treated with versus without APD and, within the sample of APD‐treated patients, for (1) specific APD, (2) sex, (3) main diagnosis, and (4) age. Results N = 54 cases (2.6%) of hypothermia occurred in APD‐treated patients and 12 cases (1.3%) in non‐APD‐treated patients (p = 0.024). In APD‐treated patients, only male sex (p = 0.038) and pipamperone were associated with a higher incidence of hypothermia (p = 0.0017). Whereas the main diagnosis delirium showed a trend to significance, age did not correlate with hypothermia. Conclusion Medication with pipamperone was associated with an increased risk of hypothermia. The advanced age of our sample might as well explain the high incidence of hypothermia within our sample and the failure to detect high age as a risk factor due to a ceiling effect.

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Risk Factors for Hypothermia in Psychiatric Patients

Cited by 36 publications

References 17 publications

Hypothermie unter Olanzapin

Hypothermie unter Olanzapin

Osborn waves in the electrocardiogram, hypothermia not due to exposure, and death due to diabetic ketoacidosis

Characteristics of antipsychotic drug‐induced hypothermia in psychogeriatric inpatients

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