Risk Factors for Increased Bone Loss in an Elderly Population The Rotterdam Study

Abstract

The association of bone loss with age, sex, and several prevalent and modifiable potential risk factors for osteoporosis was studied in 1,856 men and 2,452 women aged 55 years and over from the Rotterdam Study, a population-based cohort study in the Netherlands. The rate of change in femoral neck bone mineral density was estimated longitudinally between 1990 and 1995, after 2 years of follow-up on average. These rates, adjusted for age and body mass index, were -0.0025 (95% confidence interval -0.0038 to -0.0012) in men and -0.0045 (95% confidence interval -0.0056 to -0.0034) g/cm2/year in women (p=0.03). Bone loss accelerated with age, as seen more clearly in men than in women. Lower body mass index and cigarette smoking were associated with increased bone loss in both men and women. In men, higher calcium intake was associated with lower rates, and disability was associated with borderline significantly higher rates of bone loss (p=0.07). In women, a nonsignificant relation was observed with disability, but not with dietary calcium intake. Alcohol intake was not consistently related to the rate of bone loss in either sex. It is concluded that in elderly people the rate of bone loss is higher in women, progresses with age, and is further determined by several modifiable risk factors, particularly in men.

Beverage-specific alcohol intake and bone loss in older men and women: a longitudinal study

“…Initial reports suggested this association was U-shaped, but the differences were not significant (Burger et al, 1998;Hannan et al, 2000). Recently, an inverted U-shape curve was showed in a cross-sectional study in old men, but not in women (Tucker et al, 2009), whereas a meta analysis has described a linear relationship between femoral neck bone density and alcohol consumption (Berg et al, 2008).…”

Heritability of bone density: Regional and gender differences in monozygotic twins

“…6 Environmental factors also affect the risk for future fracture and include physical activity, calcium intake, smoking, and possibly alcohol intake. [6][7][8][9][10] While some studies have found site-specific gender differences in BMD heritability, others have observed no gender differences. 2 Many of these studies were limited in their site selection, often focusing mostly on BMD of the hip, spine, femoral neck and forearm, and only one 11 was a twin study.…”

Randomized withdrawal of long‐term prednisolone treatment in rheumatoid arthritis: effects on inflammation and bone mineral density

“…Доказано, что ежегодная потеря МПК у больных с РА более выражена, чем в популяции. Например, в Роттер-дамском исследовании [11], включавшем 4333 человека без РА в возрасте старше 55 лет, было выявлено сниже-ние МПК через 2 года с момента начала исследования на 0,4% у мужчин и на 0,6% у женщин, а у больных с ранней стадией РА идентичного возраста, согласно исследова-нию BeSt, МПК в шейке бедра снижалось на 1,4 и 1,5% соответственно уже через год после начала исследова-ния, несмотря на то что все пациенты получали базис-ную терапию. Рассматривается целый ряд причин увели-чения риска ОП при РА.…”