Risk Factors for Intracranial Infection Secondary to Penetrating Craniocerebral Gunshot Wounds in Civilian Practice

Jimenez, Carlos; Polo, J.M.; España, Julian Andres

doi:10.1016/j.wneu.2012.06.025

Cited by 35 publications

(25 citation statements)

References 22 publications

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“…Post traumatic intracranial infection is generally due to contamination that caused by foreign body entered into the brain parenchyma after the injury [2]. Intracranial infection is commonly manifested as seizures, altered mental status, and cranial nerve palsy [3].…”

Section: Introductionmentioning

confidence: 99%

Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection

Yin

Song²,

Pan

2017

J Inflamm

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BackgroundIntracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of miR-155 in lipopolysaccharide (LPS)-induced inflammatory injury in mouse microglia BV2 cells.ResultsThe expression level of miR-155 was significantly up-regulated after LPS stimulation in BV2 cells. LPS administration decreased BV2 cell viability, promoted apoptosis and increased the release of pro-inflammatory cytokines; while miR-155 knockdown rescued BV2 cell from LPS-induced injury. RACK1 was a directly target of miR-155. Interestingly, miR-155 knockdown did not attenuate LPS-induced inflammatory injury when RACK1 was knocked down. The mechanistic study indicated that miR-155 knockdown deactivated MAPK/NF-κB and mTOR signaling pathways under LPS-treated conditions.ConclusionsKnockdown of miR-155 protected mouse microglia BV2 cells from LPS-induced inflammatory injury via targeting RACK1 and deactivating MAPK/NF-κB and mTOR signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection

Yin

Song²,

Pan

2017

J Inflamm

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“…Risk factors associated with infection include contaminated wound due to dirt, penetrating object passing from contaminated paranasal cavity with communication to cerebrospinal fluid and prolong hospital stay. 14 The infection rate is higher in children than adults with retained bone fragments 13 less common complications are cerebral abscess, cerebrospinal f luid f istula, and neuroendocrine dysfunction. Prognosis of patients depends on age, mode of injury, area of the brain involved, associated other condition such as coagulopathy, hypotension, radiological finding of underlying brain hematoma and preoperative neurological status which is the reflection of underlying parenchyma injury.…”

Section: Discussionmentioning

confidence: 99%

Key in Brain: An Interesting Case of Civilian Penetrating Head Injury

Kotecha

Diyora

Patil

et al. 2016

IJNT

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Civilian penetrating head injuries are not common, and the occurrence of such injuries in the pediatric population is rare. Pediatric penetrating head injuries are low-velocity injuries, resulting from household objects. Presentation entirely depends on the area of the brain involved. There are several management dilemmas related to the nature, size, shape, and location of the object, but always warrants removal of the foreign body into the operation theater. The outcome depends on the presenting neurological status of the patient, which reflects underlying parenchymal injury. We are reporting an interesting case of civilian penetrating head injury in a 5-year-old female child with a key in the brain. Computed tomographic scan of the brain revealed a household key penetrated through the right temporal bone. The patient underwent a surgical procedure for the removal of the key. She recovered well without any neurological deficit.

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“…However, infectious processes were related to a poor prognosis 10 , antibiotic prophylaxis being recommended. Jimenez et al 11 mention an infection rate of 25%, with the following independent risk factors for infection: persistence of bone or metal fragments in the Table 2 Table 2 Table 2 Table 2 Table 2 Table 3 Table 3 Table 3 Table 3 Table 3 Total Total 3-5 0 4 55 9 68 6-8 2 20 6 7 35 9-12 5 10 1 4 20 13-15 19 31 2 6 58 Total 26 65 64 26 181 Table 1 -Table 1 -Table 1 -Table 1 - Table 1 -Distribution of the patients according to GCS at admission. Glasgow Coma Scale Glasgow Coma Scale Glasgow Coma Scale Total Total Total Total Total 3-5 68 6-8 35 9-12 20 13-15 58 Total 181 parenchyma after operation (relative risk -RR -7.45), trajectory of the projectile by a natural cavity with contaminated flora (RR 2.84) and lengthy hospitalization (RR 2.84%).…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Traumatismo cranioencefálico por projétil de arma de fogo: experiência de 16 anos do serviço de neurocirurgia da Santa Casa de São Paulo

Souza

Todeschini

Veiga

et al. 2013

Rev. Col. Bras. Cir.

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Risk Factors for Intracranial Infection Secondary to Penetrating Craniocerebral Gunshot Wounds in Civilian Practice

Cited by 35 publications

References 22 publications

Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection

Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection

Key in Brain: An Interesting Case of Civilian Penetrating Head Injury

Traumatismo cranioencefálico por projétil de arma de fogo: experiência de 16 anos do serviço de neurocirurgia da Santa Casa de São Paulo

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