Risk factors for melanoma incidence in prospective follow-up. The importance of atypical (dysplastic) nevi

Schneider, J.

doi:10.1001/archderm.130.8.1002

Cited by 29 publications

(27 citation statements)

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“…Above all, their knowledge about melanocytic nevi included false items: about 33% of them still think that malignant melanoma might develop by occasional trauma of clinically benign nevi, while it is well known that the majority of malignant melanomas can arise de novo and that only 20% of them develop on a ‘dysplastic nevus’ [8, 9]. …”

Section: Discussionmentioning

confidence: 99%

General Practitioners’ Accuracy in Diagnosing Skin Cancers

et al. 2002

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Background: The incidence of both melanoma and nonmelanocytic skin cancers has risen dramatically during the past decades, skin cancer becoming an important public health concern. Objective: The purpose of this study was to assess the ability of general practitioners (GPs) in the early diagnosis of skin cancers, their correct differential diagnosis of benign lesions and their accuracy in the choice of the treatment. Methods: A multiple-choice questionnaire regarding 7 cases (with 4 figures) were sent to 625 GPs to evaluate their diagnostic abilities. Conclusions: The results indicate that many GPs are not confident in their ability to recognize the most common skin cancers, and knowledge deficiencies were identified.

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Section: Discussionmentioning

confidence: 99%

General Practitioners’ Accuracy in Diagnosing Skin Cancers

et al. 2002

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“…Multiple epidemiologic studies have proposed several risk factors for the development of melanoma with the most important being excessive sun exposure, a prominent mole pattern, and a fair skin phenotype with a propensity to sunburn [8][9][10][11][12]. Investigation of the precise set of risk factors of melanoma in Greece would be intriguing, taking in consideration the high year-round ambient UV exposure and the significant portion of individuals with a darker, ''sun-protective'' skin complexion.…”

Section: Introductionmentioning

confidence: 99%

Risk associations of melanoma in a Southern European population: results of a case/control study

Nikolaou

Sypsa

Stefanaki

et al. 2008

Cancer Causes Control

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“…The ensuing controversy persists and, curiously, the discussion appears to be concerned with terminology rather than with a more precise characterization of this phenotype on a clinical or histological basis [6,31,39]. Nevertheless, it emerges that a large number of nevi, regardless of their clinical or histological aspect, is associated with an increased risk of malignant melanoma [24,37,38,39,42] even in extracutaneous sites [42]. In this setting, it is well conceivable that the nevi known as dysplastic, being the most prevalent type overall, should account for an important percentage of the nevi in melanoma patients.…”

Section: Discussionmentioning

confidence: 99%

“…Dysplastic nevus syndrome (DNS) is characterized by the occurrence of multiple acquired nevi, especially in non-sunexposed areas of the body and is associated with an increased risk for malignant melanoma [4,5,11,14,17,23,25,37,39,40]. Nevi of such patients are claimed to have a clinically atypical appearance [5,11,17,18], and corresponding histomorphological criteria have been proposed [5,7,9,10,11,36].…”

Section: Introductionmentioning

confidence: 99%

A distinctive melanocytic lesion associated with melanoma-prone dysplastic naevus syndrome: the hybrid naevus

Schubert¹,

Parwaresch²,

Rudolph³

2001

Virchows Archiv

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Clinically and histologically, the concept of dysplastic nevi remains controversial. To elaborate more precise criteria for the nevi of patients with dysplastic naevus syndrome (DNS), we examined 58 nevi from seven DNS patients who developed one or several malignant melanomas. Clinical presentation and histomorphology were evaluated, and immunohistochemistry was performed using proliferation marker Ki-S5 and antibody DO-7 to the p53 protein. Sixty nevi from individuals without history of melanoma served as controls. Of the DNS nevi, 21 (36.2%) exhibited no morphological particularities. The remaining 37 nevi presented distinctive histological features consisting of a slight epidermal acanthosis, spitzoid vertically oriented nests of dyscohesive nevus cells, and single-standing atypical melanocytes in the basal cell layer of the epidermis. Immunohistochemical analysis revealed an average proliferation index of 2.5%, which significantly surpassed the mean growth fraction of conventional dysplastic nevi (<1%). No increase in p53 expression was observed. Characteristically, active proliferation was found in junctional single-standing melanocytes with or without nuclear atypia rather than in nest-shaped compounds. In conclusion, certain moles of patients with DNS possess distinctive features. The newly characterized criteria may provide a basis for the diagnosis of DNS and might help to identify patients at increased risk for malignant melanoma by examination of a single biopsy.

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Risk factors for melanoma incidence in prospective follow-up. The importance of atypical (dysplastic) nevi

Cited by 29 publications

References 0 publications

General Practitioners’ Accuracy in Diagnosing Skin Cancers

General Practitioners’ Accuracy in Diagnosing Skin Cancers

Risk associations of melanoma in a Southern European population: results of a case/control study

A distinctive melanocytic lesion associated with melanoma-prone dysplastic naevus syndrome: the hybrid naevus

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