Risk factors for meniscal body extrusion on MRI in subjects free of radiographic knee osteoarthritis: longitudinal data from the Osteoarthritis Initiative

Zhang, Fan; Kumm, J.; Svensson, Fredrik; Turkiewicz, Aleksandra; Frobell, Richard; Englund, Martin

doi:10.1016/j.joca.2015.12.003

Cited by 45 publications

(40 citation statements)

References 34 publications

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“…At large, we found that women without OA had similar degree of meniscal body extrusion and cartilage coverage as men without OA. We further corroborate previous findings that the presence of ipsilateral meniscus damage was associated with meniscal extrusion in the medial compartment [8, 15, 17, 18, 23–25, 32–34]. Similar to prior reports, our cross-sectional data cannot answer the question whether meniscus damage, typically consisting of horizontal cleavages and/or flap tears (or in elderly women, simply meniscus maceration/destruction), is a result of a more mobile meniscus, or if the extrusion and displacement are a result of an already damaged meniscus and potentially disrupted hoop-tension.…”

Section: Discussionsupporting

confidence: 91%

“…Similar to prior reports, our cross-sectional data cannot answer the question whether meniscus damage, typically consisting of horizontal cleavages and/or flap tears (or in elderly women, simply meniscus maceration/destruction), is a result of a more mobile meniscus, or if the extrusion and displacement are a result of an already damaged meniscus and potentially disrupted hoop-tension. However, a prior longitudinal report based on Osteoarthritis Initiative data has provided evidence in support of the latter [25]. Either way, a damaged and extruded meniscus can no longer optimally fulfill its main purpose to distribute loads on the surrounding hyaline cartilage surfaces.…”

Section: Discussionmentioning

confidence: 99%

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Meniscal body extrusion and cartilage coverage in middle-aged and elderly without radiographic knee osteoarthritis

et al. 2018

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ObjectivesTo determine meniscal extrusion and cartilage coverage on magnetic resonance (MR) images and factors associated with these parameters in knees of middle-aged and elderly persons free from radiographic tibiofemoral osteoarthritis (OA).MethodsSeven hundred eighteen persons, free of radiographic tibiofemoral OA, aged 50–90 years from Framingham, MA, USA, were included. We measured meniscal extrusion on 1.5 T MRI of both knees to evaluate both medial and lateral meniscal body extrusion and cartilage coverage. We also determined meniscal morphology and structural integrity. The multivariable association with age, body mass index (BMI), and ipsilateral meniscal damage was also evaluated.ResultsThe mean meniscal body extrusion medially was 2.7 mm and laterally 1.8 mm. The tibial cartilage coverage was about 30% of ipsilateral cartilage surface (both compartments). The presence of ipsilateral meniscal damage was associated with more extrusion in only the medial compartment, 1.0 mm in men and 0.6 mm in women, and less cartilage coverage proportion, -5.5% in men and -4.6% in women.ConclusionsMean medial meniscal body extrusion in middle-aged or older persons without radiographic tibiofemoral OA approximates the commonly used cutoff (3 mm) to denote pathological extrusion. Medial meniscal damage is a factor associated with medial meniscal body extrusion and less cartilage coverage.Key Points • Medial meniscal extrusion in middle-aged/older persons without OA is around 3 mm. • Lateral meniscal extrusion in middle-aged/older persons without OA is around 2 mm. • Meniscal damage is associated with medial meniscal extrusion and less cartilage coverage. Electronic supplementary materialThe online version of this article (10.1007/s00330-018-5741-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Meniscal body extrusion and cartilage coverage in middle-aged and elderly without radiographic knee osteoarthritis

et al. 2018

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“…Englund et al showed that a higher BMI is related to meniscal extrusion, although this was not confirmed in another study sample 3,4 . Since obesity is modifiable, one can hypothesize that losing weight might reduce or reverse extrusion, thus preventing development or progression of knee OA.…”

Section: Discussionmentioning

confidence: 83%

“…It can occur secondary to meniscal tears 2,3 , but multiple other factors are related to extrusion, including higher age, obesity, history of knee trauma, malalignment and generalized osteoarthritis (OA) 4,5 . The generally accepted idea is that a displaced meniscus affects the weight-bearing and load distribution capacities within the knee joint, which leads to loss of cartilage and increase in bone marrow lesions, ultimately resulting in knee OA [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women

Voet

Runhaar

Plas

et al. 2017

Osteoarthritis and Cartilage

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ObjectiveTo investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological knee OA at baseline. we determined the association between knees with and without meniscal extrusion and both outcomes, corrected for the baseline differences.Results 640 knees were available at baseline of which 24% (153) had meniscal extrusion. There was a significantly higher incidence of KOA according to the primary outcome measure in women with meniscal extrusion compared to those without extrusion (28.8%, OR 2.39, 95% CI 1.53, 3.73). A significantly higher incidence was found for the development of radiographic knee OA (12.4%, OR 2.61, 95% CI 1.11, 6.13) and medial JSN (11.8%, OR 3.19, 95% CI 1.59, 6.41). Meniscal extrusion was not significantly associated with clinical knee OA and lateral JSN. 4 ConclusionMeniscal extrusion was associated with a significantly higher incidence of KOA, providing an interesting target for early detection of individuals at risk for developing KOA.

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“…This was also shown in other studies. (20,21) Meniscal extrusion was also seen with higher frequency in those patients with a history of trauma (36.8%) in contrast to those without trauma (9.1%).…”

Section: Discussionmentioning

confidence: 99%

Cross Sectional Study of The Pattern of Abnormalities in The Knee Joint Detected by Knee MRI in Patients Evaluated at Tikur Anbessa Specialized Hospital, Addis Ababa University, Addis Ababa, Ethiopia from April–August 2017

Solomon¹,

Gizaw²,

Admassie³

et al. 2018

Int J Cont Res Rev

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Introduction: The knee joint, the largest joint in the body, has several functions which are essential for human beings to walk, run and jump. Primarily, it enables flexion-extension of the lower limb in the sagittal plane. Joint stability during movement is attained by the shape of the articular surfaces, the collateral and cruciate ligaments, the menisci and tendons and muscles crossing the knee joint. (1) The vulnerability of the knee, the largest joint in the body, to direct trauma makes knee injuries very common throughout life. (2) MRI visualizes most components of the knee joint, including articular cartilage, menisci, intra-articular ligaments, synovium, bone marrow, subchondral cysts, and other periarticular and intra-articular lesions that are not detectable by radiography. (4). The prevalence of abnormalities of these different joint components as detected by MRI has been studied in different centers. Such types of studies, to date, have not been done in our country to our knowledge. The aim of this paper is to study prevalence of these abnormalities in the knee joint detected by knee MRI. Objective: To assess the prevalence of abnormalities in the knee joint detected by knee MRI. Methods: Hospital based prospective cross sectional study was conducted on 49 patients who had knee MRI at Tikur Anbessa Specialized Hospital in a period of 7 months from January 1 to August 2016. Patients included here are those who had knee MRI and no history of knee surgery. Results: A total of 49 patients were included in the study out of which 26(53.1%) were male and 23 (46.9%) were female, with a mean age of 43 years (range 17 to 68 years). The three most common pathologies were joint effusion seen in 32(65.3%), bone marrow edema in 22(45.8%) and osteophytes in 22(44.9%). ACL tear was the commonest ligament abnormality occurring in 5 (10.4%) patients. Ten (20.8%) patients had meniscal tear, all involving the medial meniscus with the posterior horn being involved in 8(80%) of these patients. Conclusion: The mean age of our study population was higher than most referenced papers suggestive for possible delayed health seeking. The commonest knee pathologies were similar to other studies. Features of osteoarthritis were seen in higher frequency in our study population. Even though the higher mean age could be the possible cause, further study is recommended to look into the causes. Abnormalities which were seen with higher frequency in those with a history of trauma were also seen in higher frequency in the male population.

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Risk factors for meniscal body extrusion on MRI in subjects free of radiographic knee osteoarthritis: longitudinal data from the Osteoarthritis Initiative

Cited by 45 publications

References 34 publications

Meniscal body extrusion and cartilage coverage in middle-aged and elderly without radiographic knee osteoarthritis

Meniscal body extrusion and cartilage coverage in middle-aged and elderly without radiographic knee osteoarthritis

Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women

Cross Sectional Study of The Pattern of Abnormalities in The Knee Joint Detected by Knee MRI in Patients Evaluated at Tikur Anbessa Specialized Hospital, Addis Ababa University, Addis Ababa, Ethiopia from April–August 2017

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