Risk factors for microalbuminuria in black americans with newly diagnosed type 2 diabetes

Kohler, Kathryn A.; McClellan, William M.; Ziemer, David C.; Kleinbaum, David G.; Boring, John R.

doi:10.1053/ajkd.2000.19080

Cited by 50 publications

(33 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the baseline HbA1c levels in other studies were higher than in our cohort, and higher HbA1c levels have been shown to be a significant predictor of albuminuria among patients with newly diagnosed type 2 diabetes mellitus [19].…”

Section: Discussioncontrasting

confidence: 48%

Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus

et al. 2014

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 48%

Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus

et al. 2014

View full text Add to dashboard Cite

“…Kohler et al evaluated 1,044 diabetic black patients having less than 2 years disease duration. Macroalbuminuria was detected in 3.8% and 23.4% had microalbuminuria [20]. Thirty percent of black patients with diabetes duration less than 1 year had proteinuria in the report by Goldschmid et al [19], 25% microalbuminuria and 5% overt proteinuria.…”

Section: Discussionmentioning

confidence: 88%

“…Thirty percent of black patients with diabetes duration less than 1 year had proteinuria in the report by Goldschmid et al [19], 25% microalbuminuria and 5% overt proteinuria. As in this report, the studies by Kohler et al [20] and Goldschmid et al [19] included patients from the southeastern United States.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Prevalence of Nephropathy in Black Patients with Type 2 Diabetes mellitus

Gitter

Langefeld²,

Rich³

et al. 2002

Am J Nephrol

View full text Add to dashboard Cite

The prevalence of nephropathy in black patients with type 2 diabetes mellitus is poorly defined. We performed a cross-sectional analysis of 98 unrelated and unselected black type 2 diabetic patients treated in indigent care internal medicine clinics to determine the prevalence of proteinuria and nephropathy. Serum creatinine, blood urea nitrogen, urine albumin and urine creatinine concentrations were measured. A Spearman’s rank correlation was computed to test for a relationship between diabetes duration and continuous outcomes. For binary outcomes, an odds ratio and 95% confidence interval were computed for a change of 10 years diabetes duration based on logistic regression. Cases were 61% female, and had mean (± SD) age 59.9 ± 12.5 years, diabetes duration 12.6 ± 9.4 years, body mass index 32.4 ± 9.3 kg/m², hemoglobin A1C (HbA1C) 9.2 ± 2.3%, and serum creatinine concentration 1.60 ± 1.1 mg/dl. For continuous variables, diabetes duration was positively associated with albuminuria (r = 0.31; p = 0.0017), serum creatinine (r = 0.36; p = 0.0003) and blood urea nitrogen concentration (r = 0.36; p = 0.0003). For binary variables, cases with longer diabetes duration were at increased risk for urinary albumin:creatinine >300 µg/mg (p = 0.006), elevated serum creatinine concentration (≧1.4 mg/dl in women or ≧1.6 mg/dl in men; p = 0.045), elevated blood urea nitrogen concentration (≧20 mg/dl; p = 0.026), and clinical cerebrovascular disease (p = 0.028). HbA1C, body mass index, and blood pressure did not correlate with diabetes duration in this population. Among the cases, 33.7% had elevated serum creatinine concentration and 71.5% had abnormal levels of albuminuria (27.6% > 300 µg albumin/mg Cr and 43.9% 30–300 µg albumin/mg Cr). Abnormal proteinuria was seen in the majority of black patients with poorly controlled type 2 diabetes mellitus treated in indigent care clinics. This prevalence may be conservative, due to the widespread use of angiotensin-converting enzyme inhibitor therapy and exclusion of cases treated only by nephrologists. Approximately 70% of black patients with type 2 diabetes cared for in indigent care clinics have abnormal proteinuria and are at heightened risk for ESRD and death.

show abstract

“…They are responsible for restricting the passage of proteins from blood to the urinary space However, these abnormalities are reversible with weight loss [5] . Positive correlation between albuminuria and body weight and body mass index has been found in diabetics as well as in non-diabetic subjects [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

The role of oxidative stress in renal injury related to obesity

Pierine

Biondo

Silva

et al. 2015

Inflamm Cell Signal

View full text Add to dashboard Cite

The mechanisms linking obesity to kidney damage are unknown. AGEs are responsible for renal damage in obese individuals. The receptor AGEs (RAGE) contributes to nuclear transcription factors that result in the production of proinflammatory cytokines and this seems to contribute to the development of renal disease. Thus, intervention with antioxidant can have an important effect in the prevention and treatment of pro-oxidant and pro-inflammatory state in the kidneys resulting from obesity.

show abstract

Risk factors for microalbuminuria in black americans with newly diagnosed type 2 diabetes

Cited by 50 publications

References 49 publications

Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus

Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus

Prevalence of Nephropathy in Black Patients with Type 2 Diabetes mellitus

The role of oxidative stress in renal injury related to obesity

Contact Info

Product

Resources

About