Risk Factors for Periprosthetic Joint Infections Following Primary Total Hip Arthroplasty

Michael, Jesenko; Windhager, Reinhard; Kontekakis, Antonis; Tim, Hanstein; Klaus-Dieter, Kuehn

doi:10.13189/ujmsj.2016.040105

Cited by 1 publication

(1 citation statement)

References 43 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Well-established infection around the implant results in necrosis of the surrounding tissue, often requiring surgical debridement. Extensive tissue necrosis breaks down the bone-implant interface, causing loosening of the implant and loss of limb function, which then requires surgical retrieval and replacement of the implant [7,8]. Implant retrieval not only incurs significant financial costs and patient discomfort but also results in further bone tissue loss, meaning that implant replacement can only be performed a limited number of times over the lifetime of the patient.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces

Townsend

Williams

Anuforom

et al. 2017

J. R. Soc. Interface.

View full text Add to dashboard Cite

The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material-tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.

show abstract

Section: Introductionmentioning

confidence: 99%