Risk Factors for Placental Malaria and Its Effect on Pregnancy Outcome in Yaounde, Cameroon

Tako, Ernest A.; Zhou, Ainong; Lohoue, J.; Leke, Robert J. I.; Taylor, Diane Wallace; Leke, Rose G. F.

doi:10.4269/ajtmh.2005.72.236

Cited by 123 publications

(129 citation statements)

References 31 publications

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“…The malaria parasites either directly cause mechanical compromise of placental circulation via widespread trophoblast membrane thickening, increased fibrinoid necrosis and cytotrophoblast prominence or indirectly interfere with placental function and induce pathological lesions. 31 The finding in this study agrees with those of Bako et al, 6 Okoko et al, 24 and Tako et al 18 .…”

Section: Discussionsupporting

confidence: 83%

“…18 Higher rates of 33.2% and 53.6% were previously reported by Adebami et al 19 and BouyouAkotet et al 20 in Ile -Ife, Nigeria and Gabon respectively. The lower prevalence reported in this study may be due to the effective malaria control measures employed in the population, which include sulphadoxine -pyrimethamine 20 Several studies have shown that parity influences susceptibility to placental malaria with primigravidae being more susceptible compared to multigravidae.…”

Section: Discussionsupporting

confidence: 55%

“…[6][7][8][9] Various studies have linked placental malaria to maternal anaemia. 18,24 However, in this study, there was no significant association between placental malaria and maternal anaemia when controlled for the other confounding variables, using the multivariate logistic regression model. This could be attributable to the fact that all the women in the study were booked and received antenatal care that included management of the risk factors for anaemia as well as correction of anaemia.…”

Section: Discussionmentioning

confidence: 99%

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Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

et al. 2015

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Background: Malaria is the most common human parasitic disease and continues to be a complex and overwhelming global health problem, especially in sub-Saharan Africa. Placental malaria, one of the major features of malaria in pregnancy has been associated with serious adverse health consequences to both the mother and her fetus. Objective: This study sought to determine the prevalence of maternal, cord, and placental malarial parasitaemia at parturition, the association between maternal and placental parasitaemia, and also the association between placental parasitaemia and pregnancy outcomes. Materials and Methods: A descriptive cross-sectional design was used to study 330 pregnant women selected by the systematic random sampling technique as they presented in the labour ward of University of Uyo Teaching Hospital, Uyo between April, 2012 and September, 2012. Pre-delivery, maternal peripheral blood was taken for malaria parasite (MP) and packed cell volume (PCV). Post delivery, cord blood was taken for MP and PCV estimation while placental blood was examined for MP. Neonatal demographic and clinical characteristics were also obtained. The data was analyzed using SPSS version 17. Level of statistical significance was set at P less than 0.05 (P < 0.05). Results: The mean age of the respondents was 28.8 ± 4.4 years. The prevalence of maternal, cord, and placental parasitaemia were 30.3%, 14.8% and 18.2% respectively. There was a strong correlation between maternal parasitaemia and placental parasitaemia (rho = 0.75, P< 0.001). Also, a significant linear association between cord parasitaemia and placental malaria (rho = 0.87, p< 0.001) was found. Placental malaria predisposed to low birth weight (OR 1.01{95%CI 1.001 – 1.02}, p = 0.04) and fetal anaemia (OR 1.02{95%CI 1.01 – 1.03}, p < 0.001. Conclusion: There is a relatively high prevalence of placental parasitaemia at parturition. Placental malaria is associated with adverse pregnancy outcomes such as low birth weight, fetal anaemia and cord parasitaemia. Proven strategies to prevent malaria in pregnancy such as use of ITNs and IPT and free antenatal care should be intensified to curb this deadly but preventable disease.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12401Asian Journal of Medical Sciences Vol.6(6) 2015 53-59

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

et al. 2015

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“…Factors that influence the prevalence of malaria in pregnant women were identified and include maternal age, parity, use of prophylaxis, nutrition, genetics of the host, level of anti-parasitic immunity and genetics of the parasite 16 .…”

Section: Introductionmentioning

confidence: 99%

Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Campos

Valente

Campos³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Malaria during pregnancy remains a serious public health problem. The aim of this study was to establish the prevalence and possible risk factors for malaria in pregnant women attending antenatal care at Augusto Ngangula Specialized General Hospital in Luanda, Angola. Methods: Pregnant women (679 total) who attended antenatal care from April to September 2008 were included in the study after signing informed consent. For each participant, the social-demographic profile and malaria and obstetric histories were investigated via a questionnaire. Diagnosis was made by optic microscopy, and hemoglobin concentration measured. The associations between age, parity, gestational age, residence, schooling, malaria during gravity, anemia and treatment with incidence of Plasmodium falciparum infection were analyzed through logistic regression. Results: During the period of study, 74 (10.9%) out of 679 women were infected by P. falciparum. The average concentration of hemoglobin was 11.1 ± 0.07g/dL, and there were significant associations between the history of malaria during pregnancy, P. falciparum infection (p<0.01) and anemia at the time of observation (p<0.001). Conclusions: Previous history of malaria during pregnancy represents a risk factor for current infection and anemia was an important complication associated with malaria, even in women who were treated with sulfadoxine-pyrimethamine during pregnancy.

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“…Malaria contributes significantly to perinatal disease burden in terms of pregnancy loss, prematurity and intra-uterine growth retardation (IUGR) [1][2][3]. Despite these well-documented indirect effects of malaria to the fetus and newborn, the direct burden of neonatal malaria infection in terms of prevalence and outcome is not well described in malaria endemic areas.…”

Section: Introductionmentioning

confidence: 99%

Clinical Presentation and Management of Neonatal Malaria: A Review

D¹

2014

Malaria Contr Elimination

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The burden of neonatal malaria was thought rare in the past because of presence of protective factors such as maternal antimalarial antibodies, lactoferrin, secretary IgA in human milk and HbF. In endemic areas for malaria, this group (neonates) needs to be more focused for such infection, as due to difficulty in diagnosis it may be representing only the tip of iceberg. In addition there is little information on the use of artimisinin-based combination therapy in neonates. This review aims to discuss all these aspects, focusing mainly on diagnosis and management of neonatal malaria. The final objective is to emphasize the need to establish management guideline of malaria in this neglected age group.

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Risk Factors for Placental Malaria and Its Effect on Pregnancy Outcome in Yaounde, Cameroon

Cited by 123 publications

References 31 publications

Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola

Clinical Presentation and Management of Neonatal Malaria: A Review

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