Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less than 1250 g

Frezza, Simonetta; Maggio, Luca; Carolis, Maria Pia De; Gallini, Francesca; Puopolo, Maria; Polimeni, Valentina; Costa, Simonetta; Vento, Giovanni; Tortorolo, Giuseppe Gio Batta

doi:10.1007/s00431-004-1571-1

Cited by 15 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This gender distribution is consistent with reported data [15,16]. Nine of the 12 surviving infants were delivered by cesarean, as were 5 of the 13 that died within 31 days of delivery.…”

Section: Discussionsupporting

confidence: 91%

Neonatal outcome and two‐year follow‐up after expectant management of second trimester rupture of membranes

Pristauz

Bauer

Maurer-Fellbaum

et al. 2008

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…This gender distribution is consistent with reported data [15,16]. Nine of the 12 surviving infants were delivered by cesarean, as were 5 of the 13 that died within 31 days of delivery.…”

Section: Discussionsupporting

confidence: 91%

Neonatal outcome and two‐year follow‐up after expectant management of second trimester rupture of membranes

Pristauz

Bauer

Maurer-Fellbaum

et al. 2008

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Infants with a birth weight of less than 1250 g comprise the group with the highest risk of developing pulmonary candidiasis [45]. …”

Section: Discussionmentioning

confidence: 99%

Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system

Zaga‐Clavellina

Ruiz

Flores-Espinosa

et al. 2012

Reprod Biol Endocrinol

View full text Add to dashboard Cite

BackgroundDuring intrauterine infection, amniochorionic membranes represent a mechanical and immunological barrier against dissemination of infection. Human beta defensins (HBD)-1, HBD-2, and HBD-3 are key elements of innate immunity that represent the first line of defense against different pathogen microorganisms associated with preterm labor. The aim of this work was to characterize the individual contribution of the amnion (AMN) and choriodecidua (CHD) regions to the secretion of HBD-1, HBD-2 and HBD-3, after stimulation with Candida albicans.MethodsFull-thickness human amniochorionic membranes were obtained after delivery by elective cesarean section from women at 37-40 wk of gestation with no evidence of active labor. The membranes were cultured in a two-compartment experimental model in which the upper compartment is delimited by the amnion and the lower chamber by the choriodecidual membrane. One million of Candida albicans were added to either the AMN or the CHD face or to both and compartmentalized secretion profiles of HBD-1, HBD-2, and HBD-3 were quantified by ELISA. Tissue immunolocalization was performed to detect the presence of HBD-1, -2, -3 in tissue sections stimulated with Candida albicans.ResultsHBD-1 secretion level by the CHD compartment increased 2.6 times (27.30 [20.9-38.25] pg/micrograms protein) when the stimulus with Candida albicans was applied only on this side of the membrane and 2.4 times (26.55 [19.4-42.5] pg/micrograms protein) when applied to both compartments simultaneously. HBD-1 in the amniotic compartment remained without significant changes. HBD-2 secretion level increased significantly in the CHD when the stimulus was applied only to this region (2.49 [1.49-2.95] pg/micrograms protein) and simultaneously to both compartments (2.14 [1.67- 2.91] pg/micrograms protein). When the stimulus was done in the amniotic compartment HBD-2 remained without significant changes in both compartments. HBD-3 remained without significant changes in both compartments regardless of the stimulation modality. Localization of immune-reactive forms of HBD-1, HBD-2, and HBD-3 was carried out by immunohistochemistry confirming the cellular origin of these peptides.ConclusionSelective stimulation of amniochorionic membranes with Candida albicans resulted in tissue-specific secretion of HBD-1 and HBD-2, mainly in the CHD, which is the first region to become infected during an ascending infection.

show abstract

“… CP- C. parapsilosis , CA- C. albicans and CT-OT- Others which include C. tropicalis, C. glabrata, C. lusitaniae, C. krusei, C. dublinensis and C. rugosa Studies excluded were Viudes et al (143) (neonatal data could not be extracted), Sarvikivi et al (91) (focused on fluconazole consumption and resistance in C. parapsilosis ), Frezza 2005 (144) (pulmonary candidiasis only) and Rodriguez 2006 (145) (same as Rodriguez 2010 (25). …”

Section: Figmentioning

confidence: 99%

Candida parapsilosis Is a Significant Neonatal Pathogen

Pammi

Holland

Butler

et al. 2013

Pediatric Infectious Disease Journal

184

127

View full text Add to dashboard Cite

Background Candida is the third most common cause of late-onset neonatal sepsis in infants born at < 1500 g. C. parapsilosis infections are increasingly reported in preterm neonates in association with indwelling catheters. Methods We systematically reviewed neonatal literature and synthesized data pertaining to percentage of C. parapsilosis infections and mortality by meta-analyses. We also reviewed risk factors, virulence determinants, antimicrobial susceptibility patterns and outlined clinical management strategies. Results C. parapsilosis infections comprised 33.47 % [95% CI, 30.02, 37.31] of all neonatal Candida infections. C. parapsilosis rates were similar in studies performed before the year 2000, 33.53 % [95% CI, 30.06, 37.40] (28 studies), to those after 2000, 27.00% [95% CI, 8.25, 88.37] (8 studies). The mortality due to neonatal Candida parapsilosis infections was 10.02% [95% CI, 7.66, 13.12]. Geographical variations in C. parapsilosis infections included a low incidence in Europe and higher incidence in North America and Australia. Biofilm formation was a significant virulence determinant and predominant risk factors for C. parapsilosis infections were prematurity, prior colonization and catheterization. Amphotericin B remains the antifungal drug of choice and combination therapy with caspofungin or other echinocandins may be considered in resistant cases. Conclusion C. parapsilosis is a significant neonatal pathogen, comprises a third of all Candida infections and is associated with 10% mortality. Availability of tools for genetic manipulation of this organism will identify virulence determinants and organism characteristics that may explain predilection for preterm neonates. Strategies to prevent horizontal transmission in the neonatal unit are paramount in decreasing infection rates.

show abstract

Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less than 1250 g

Abstract: The presence of preterm premature rupture of membranes and the duration of ventilation are significant risk factors for developing pulmonary candidiasis and should be considered in the preventive efforts to reduce this disease in infants with a birth weight <1250 g.

Cited by 15 publications

References 22 publications

Neonatal outcome and two‐year follow‐up after expectant management of second trimester rupture of membranes

Neonatal outcome and two‐year follow‐up after expectant management of second trimester rupture of membranes

Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system

Candida parapsilosis Is a Significant Neonatal Pathogen

Contact Info

Product

Resources

About