Risk Factors for Sclerema Neonatorum in Preterm Neonates in Bangladesh

Zeb, Amna; Rosenberg, Rebecca E.; Ahmed, Nawshad Uddin; Saha, Samir K.; Chowdhury, Azad; Ahmed, Saifuddin

doi:10.1097/inf.0b013e3181951af4

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…The prognosis of SN is very poor, with the fatality rate reported to be as high as 98% in the report of 51 preterm neonates with SN in the first 28 days of life 9 . Previous report subjected to SN patients with septicemia presents patient distribution as follows; 88.3% of the patients (54/60) born with low birth weight (<2,500 g), 65% of the patients (39/60) born in preterm period (<37 weeks), and 85% of the patients (51/60) with predisposing factors such as prolonged rupture of membranes, maternal infection, and birth asphyxia 10 .…”

Section: Discussionmentioning

confidence: 99%

Sclerema Neonatorum in a Full-Term Infant Showing Favorable Prognosis

Park

Kim

2017

Ann Dermatol

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Sclerema neonatorum (SN) is a rare disease characterized by firm, indurated, waxy skin lesions extending throughout the body, sparing the fat-free soles, palms, and genitalia. The prognosis of SN is generally very poor, with a high fatality rate. We report the case of a full-term infant with delayed onset of SN showing good prognosis. A 4-month-old Korean male infant presented with diffuse waxy, sclerotic skin lesions on the whole body, sparing the face, nipples, and genital area, which began developing at 2 months of age. Histopathologic findings of the sclerotic skin lesions showed wide, fibrous intersecting bands in the subcutaneous fat tissue. Only sparse infiltration of lymphocytes and histiocytes was observed in the fat lobules and septa. Based on clinical presentation and histopathologic findings, he was diagnosed with SN. The patient survived with conservative care and had mild improvement of the skin lesions on his follow-up visit at 12 months of age.

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Section: Discussionmentioning

confidence: 99%

Sclerema Neonatorum in a Full-Term Infant Showing Favorable Prognosis

Park

Kim

2017

Ann Dermatol

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“…It is principally documented in premature, low‐birth‐weight infants in their first few days of life who frequently have additional risk factors such as sepsis, respiratory and GI tract infections, and birth defects 1 . Fewer cases have emerged in the last decade due to advanced perinatal intensive care 2,3 ; nevertheless, novel cases are still reported, often in precarious perinatal circumstances 4 . SN carries a dismal prognosis, with mortality rates as high as 98% in most cases 5 .…”

Section: Discussionmentioning

confidence: 99%

“… 1 Fewer cases have emerged in the last decade due to advanced perinatal intensive care 2 , 3 ; nevertheless, novel cases are still reported, often in precarious perinatal circumstances. 4 SN carries a dismal prognosis, with mortality rates as high as 98% in most cases. 5 Our patient characteristically presented on the third day of life and was premature, low‐birthweight, and diagnosed with early‐onset neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

Sclerema neonatorum in a premature newborn: A case report

Alhalabi,

Salloum,

Alhalabi

et al. 2023

Skin Health and Disease

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Sclerema neonatorum (SN) is a rare condition of neonatal panniculitis with a poor prognosis and a high fatality rate. It clinically presents as hardening of the skin and subcutaneous adipose tissue extending throughout the body, sparing the fat‐free soles, palms, and genitalia. SN typically affects gravely ill, preterm neonates in the first week of life and diagnosis is often clinical. We report a case of an eight‐day‐old premature infant diagnosed with early‐onset neonatal sepsis who presented with clinical and histopathological features of SN. Despite early treatment of the sepsis with intravenous antibiotics and the SN with a topical corticosteroid cream and moisturiser, the infant died on the twelfth day of life.

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“…The prognosis in sclerema neonatorum is much worse compared to SCFN. 15 Sclerema is associated with significant morbidity and mortality. Intravenous immunoglobulin has been use to enhance humoral and cellular immunity and thus decrease the mortality associated with sclerema in a newborn.…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous immunoglobulin has been use to enhance humoral and cellular immunity and thus decrease the mortality associated with sclerema in a newborn. 15 Subcutaneous fatty tissue in newborn infants have ample saturated fat, which tends to harden with hypothermia. Hypothermia with associated clinical shock may enhance subcutaneous hardening in sclerema neonatorum.…”

Section: Discussionmentioning

confidence: 99%