Risk factors for sexual and erectile dysfunction in HIV-infected men: the role of protease inhibitors

Moreno-Pérez, Óscar; Escoín, C.; Serna-Candel, Carmen; Picó, Antonio; Alfayate, Rocı́o; Merino, Esperanza; Reus, Sergio; Boix, Vicente; Sánchez‐Paya, José; Portilla, Joaquín

doi:10.1097/qad.0b013e328334444b

Cited by 49 publications

(77 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients lost to follow-up were not reached, which may have lead to a potential overestimation of the correlation between ART and sexual dissatisfaction (as one could hypothesize that people who are lost to follow-up are more likely to feel depressed, since not caring about health is a core symptom of depression). The role of ART in the onset of sexual problems in MLHIV remains unclear, also because of the inconsistency of the results obtained in other studies [6,[15][16][17][18][19][20][21][22]. The lack of a gold standard to define sexual dissatisfaction necessitated defining an arbitrary cutoff point without proven clinical relevance.…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Sexual Satisfaction Among Men Living with HIV in Europe

et al. 2011

View full text Add to dashboard Cite

This study determined risk factors for decreased sexual satisfaction among men living with HIV (MLHIV). Self-administered questionnaires were distributed consecutively to all MLHIV attending 17 European HIV treatment centres. The sample included 1,017 MLHIV, among whom 79.2% self-identified as homosexual or bisexual. Sexual satisfaction was measured for five domains of sexual functioning and 33.2% reported low satisfaction in at least one domain. Decreased sexual satisfaction was associated with psychosocial factors, i.e. depression (OR 2.77, P < 0.001), anxiety (OR 1.77, P < 0.001), stress (OR 2.27, P < 0.001) and social factors, such as low partner support (OR 2.28, P < 0.001) and experiences of HIV related discrimination (OR 1.69, P < 0.001). Discussing satisfaction with sexuality should be integrated in regular HIV care, considering patients' personal and relationship-related resources next to medical treatment if indicated.

show abstract

Section: Discussionmentioning

confidence: 93%

“…Psychological and relational [4] factors play an important role, as well as HIV related stigma [5]. The correlation with HIV disease parameters such as CD4 count or viral load is less clear [4][5][6]. Importantly, the role of antiretroviral medication in the onset of sexual problems remains controversial [7].…”

Section: Introductionmentioning

confidence: 96%

Sexual Satisfaction Among Men Living with HIV in Europe

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Despite having similar virological response to ART like the younger patients, older patients usually have poorer clinical and immunological response [44][45][46]48 . Pt5 attributed his erectile dysfunction to ART, and although age and a protease inhibitor based ART regimen were independently associated with erectile dysfunction 49 , he was not on a protease inhibitor ART regimen. He said that the herbal medications improved his erectile function, but natural aphrodisiacs have not been found to be an effective treatment for male or female sexual dysfunctions 50 .…”

Section: Discussionmentioning

confidence: 99%

Personal barriers to antiretroviral therapy adherence: Case studies from a rural Uganda prospective clinical cohort

Mayanja¹,

Kabunga²,

Masiira³

et al. 2013

Afr H. Sci.

View full text Add to dashboard Cite

Background: Although good adherence to antiretroviral therapy (ART) is essential for successful treatment outcomes, some patients may have specific personal barriers to ART adherence. Objectives: To study specific personal barriers to ART adherence. Methods: Quantitative data on patients' health status, ART adherence, CD4 cell counts and viral loads were collected, and qualitative data on life experiences of five patients with poor ART outcomes and adherence were also collected. Results: Out of 35 patients with poor immunological and virological ART outcomes, 17 (49%) also had poor ART adherence. Patient 1 had no living child and did not disclose her HIV serostatus to her spouse because she wanted to have a child. Patient 2 was an orphan with neither social nor family support. Patient 3 stopped ART when she conceived, returned to the study clinic when pregnant again and was sickly. She was switched to second-line ART with satisfactory outcomes. Patient 4, a 14 year old orphan had missed ART for 2 months when his treatment supporter was away. Patient 5 aged 66 years stopped ART which he blamed for his erectile dysfunction. Conclusions: ART adherence counselling should target specific personal barriers to ART adherence like: lack of family support, health and sexual life concerns, desire to have children and family instability.

show abstract

“…4 However, symptoms of depression were not associated with sexual dissatisfaction, as was also found in a study among HIV-positive women in the UK 28 but not in most studies. 3,4,6,7 It is possible that generally being on ART over longer periods is associated with an increase in quality of life and a decrease in overall depression. In this study sexual risk taking, alcohol use and non-adherence to ART were not found to be associated with sexual dissatisfaction, in contrast to some other studies.…”

Section: Discussionmentioning

confidence: 99%

Sexual dissatisfaction and associated factors in a sample of patients on antiretroviral treatment in KwaZulu-Natal, South Africa

Peltzer

2011

S. Afr. J. Psych.

View full text Add to dashboard Cite

Background: Sexual expression affects physical, mental and social well-being. There is a lack of understanding on sexual problems among patients on antiretroviral treatment in Africa. Methods: Using systematic sampling, HIV-positive patients were selected prior to commencing on ART from outpatient departments from three hospitals and followed-up for 20 months (n=495) and interviewed with a questionnaire.Results: Rates of self-reported sexual problems were high (34.3%, among men: 30.3% and women 36.0%) but significantly reduced from prior to ART (57.7%) to 20 months on ART (34.3%) (P=0.006). In multivariate analysis not being formally employed (odds ratio: 0.4, 0.2-0.9), having had sexual intercourse in the past 3 months (OR: 5.8, 1.7-19.8), taking medications for HIV-related opportunistic infections (OR: 2.5, 1.1-5.7), internalized stigma (OR: 1.4, 1.2-1.6), lack of social support (OR: 0.4, 0.3-0.6), and low depressive symptoms (OR: 0.9, 0.8-1.0) were found to be associated with sexual problems.Conclusions: This prospective study with a large sample of persons on ART showed evidence of reduction of sexual problems over time and a number of factors influencing sexual problems which should be addressed in health care provider interventions.

show abstract

Risk factors for sexual and erectile dysfunction in HIV-infected men: the role of protease inhibitors

Abstract: There is a high prevalence of erectile dysfunction in HIV-infected men, with age and the duration of exposure to protease inhibitor being the only identifiable risk factors.

Cited by 49 publications

References 27 publications

Sexual Satisfaction Among Men Living with HIV in Europe

Sexual Satisfaction Among Men Living with HIV in Europe

Personal barriers to antiretroviral therapy adherence: Case studies from a rural Uganda prospective clinical cohort

Sexual dissatisfaction and associated factors in a sample of patients on antiretroviral treatment in KwaZulu-Natal, South Africa

Contact Info

Product

Resources

About