Risk Factors for Subclinical Atherosclerosis in Firefighters

Burgess, Jefferey L.; Kurzius-Spencer, Margaret; Gerkin, Richard; Fleming, James L.; Peate, Wayne F.; Allison, Matthew A.

doi:10.1097/jom.0b013e318243298c

Cited by 19 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Results of CIMT meta-analysis strengthen the evidence of early atherosclerotic development in children with FH. Circulating low-density lipoprotein (LDL-C) concentrations were associated with CIMT [ 33 , 34 ], and high levels of oxidized LDL (OxLDL) were significantly associated with progression and increased levels of CIMT [ 35 - 37 ]. Low levels of HDL cholesterol or relative levels of the HDL 3b subclasses and changes in the proportion of small HDL particles were significantly associated with an increased in CIMT [ 20 , 38 ] and with the presence of carotid plaques [ 39 ].…”

Section: The Associations Between Cimt and Traditional CV Risk Factormentioning

confidence: 99%

“…Additionally, 12Â months of Mediterranean diet intervention caused a significant reduction in CIMT [ 31 ]. Interventions to lower LDL cholesterol from the suboptimal to the optimal range were shown to have potentially significant benefits to firefighters [ 34 ]. Atorvastatin [ 47 ], rosuvastatin [ 48 ] and fuvastatin [ 49 ] treatments slowed or reduced the progression of CIMT; intensive lipid lowering and antihypertensive therapy along with a reduction in central fat [ 50 ] may be considered a mandatory treatment strategy in young patients with FH to prevent atherosclerosis and to increase arterial stiffness.…”

Section: The Associations Between Cimt and Traditional CV Risk Factormentioning

confidence: 99%

See 1 more Smart Citation

Causes of changes in carotid intima-media thickness: a literature review

2015

Cardiovasc Ultrasound

View full text Add to dashboard Cite

Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) predicts future cardiovascular and ischaemic stroke incidence. CIMT, a measure of atherosclerotic disease, can be reliably determined in vivo by carotid ultrasound. In this review, we determined that CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking, alcohol consumption, habitual endurance exercise, blood pressure, dyslipidemia, dietary patterns, risk-lowering drug therapy, glycemia, hyperuricemia, obesity-related anthropometric parameters, obesity and obesity-related diseases. We also found that CIMT is associated with novel risk factors, including heredity, certain genotypic indices, anthropometric cardiovascular parameters, rheumatoid arthritis, immunological diseases, inflammatory cytokines, lipid peroxidation, anthropometric hemocyte parameters, infectious diseases, vitamin D, matrix metalloproteinases, and other novel factors and diseases. However, the conclusions are inconsonant; the underlying causes of these associations remain to be further explored.

show abstract

Section: The Associations Between Cimt and Traditional CV Risk Factormentioning

confidence: 99%

Section: The Associations Between Cimt and Traditional CV Risk Factormentioning

confidence: 99%

Causes of changes in carotid intima-media thickness: a literature review

2015

Cardiovasc Ultrasound

View full text Add to dashboard Cite

show abstract

“…In persons with left ventricular ejection fraction >50%, plasma sP-selectin was shown to predict cardiac events [14]. In men at higher risk of cardiovascular disease, sP-selectin associates with the presence of carotid plaque [15]. In non-Hispanic white Americans, over a 10-year follow-up, baseline plasma sP-selectin was related to the future risk of coronary heart disease.…”

Section: Introductionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

View full text Add to dashboard Cite

PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics.MethodsSerum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other.Results108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m2 [18.4–22.2] vs. 21.6 kg/m2 [19.9–23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1–7.1] vs. 0.5 mg/dL [0.3–1.0], p < 10−10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851–1279] vs. 861 ng/mL [806–979], p < 10−4), sP-selectin levels did not differ (155 ng/mL [129–188] vs. 156 ng/mL [144–177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF.ConclusionsWe found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF.

show abstract

“…Varleta et al 38 showed that age, dyslipidemia, systolic blood pressure, and abdominal obesity were predictors of an increase in thickness of the carotid intima-media in a study group of 187 participants. Additionally, Burgess et al 39 reported that LDL levels >100 mg/dl, age, hypertension, and plasma-soluble P-selectin were factors that increased the risk of carotid artery plaques in a study on 597 men. In the present study, no significant difference was found in mean HDL values among the groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of risk factors that play a role in extra-cranial carotid artery atherosclerosis

Karahan-Özcan¹,

Özmen²

2019

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

Which risk factors are important in preventing or stabilizing possible extra-cranial carotid artery stenosis is unclear. We aimed to investigate risk factors that are associated with extra-cranial carotid artery stenosis in patients with ischemic stroke. Method: The records of 215 patients with ischemic stroke who were admitted to Taksim Research Hospital were screened. Patients who had been monitored with color Doppler ultrasonography were then categorized on the basis of the degree of stenosis in the carotid artery (group A: 0%-49%, group B: 50%-69%, group C: >70%). Hypertension, diabetes mellitus hyperlipidemia, cigarette smoking, ischemic heart disease, age, and sex were evaluated as risk factors. These risk factors were compared among the three groups by using SPSS version 17. Results: We found a significant relationship between high mean low-density lipoprotein and the severity of carotid stenosis (p<0.05). A simila relationship was found between sex and the severity of carotid stenosi (p<0.05). Conclusions: A high low-density lipoprotein level and male sex are important risk factors for having extra-cranial carotid artery stenosis Therefore, use of more aggressive lipid-lowering treatments, recommending an appropriate diet, and encouraging physical activity in hyperlipidemic men are important in preventive medical practice.

show abstract

Risk Factors for Subclinical Atherosclerosis in Firefighters

Abstract: This study supports an emphasis on traditional risk factors for atherosclerotic disease in firefighters, in particular maintaining LDL-C less than 100 mg/dL. Plasma soluble P-selectin may help identify firefighters at increased risk for carotid plaque.

Cited by 19 publications

References 40 publications

Causes of changes in carotid intima-media thickness: a literature review

Causes of changes in carotid intima-media thickness: a literature review

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Comparison of risk factors that play a role in extra-cranial carotid artery atherosclerosis

Contact Info

Product

Resources

About