Risk Factors for Triple-Negative Breast Cancer among Latina Women

Abstract

Breast cancer is the most common cancer in Latina women. Although they have a lower incidence of the disease when compared with other population groups such as non-Hispanic white and African-American women, some studies have shown that Latina women have a higher risk of mortality when compared with non-Hispanic white women. This phenomenon can be explained in part by the higher prevalence of aggressive subtypes in Latina women, particularly the triple negative. Such differences in breast cancer-intrinsic subtype distribution between population groups might be a conse-quence of a variety of risk factors differentially present among population groups. Here, we provide a full description of risk factors that might be associated with the high prevalence of the triple-negative subtype in Latina women. We assessed demographic (socioeconomic status), modifiable (reproductive patterns, obesity, and physical activity), and nonmodifiable (family history, germline BRCA mutations, and genetic ancestry) risk factors. The observed inconsistencies among different epidemiologic studies in Latinas warrant further research focused on breast cancer subtype-specific risk factors in this population.

Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women

“…Women diagnosed with ER/PR þ tumors tend to have better outcomes compared with women diagnosed with ER/PR À disease (36,40). Multiple studies have been conducted evaluating factors (genetic, behavioral, and environmental) that could explain subtype specific breast cancer risk (21,(41)(42)(43)(44)(45). Information about factors contributing to risk of developing HER2 þ subtypes is limited but includes common germline variants (11,(19)(20)(21).…”

Cáncer de mama triple negativo: terapias sistémicas actuales y experiencia local

“…Datos del SEER también muestran que mujeres afroamericanas y latinas tenían proporcionalmente más CMTN (AA: OR = 2,0, 134 IC 95%, 1,8-2,2; latinas: OR = 1,3, IC 95%, 1,2-1,5) en comparación con mujeres BNH. Recientemente, Rey Vargas et al 38 , en una revisión de la literatura de estudios publicados en los últimos 10 años (enero de 2008 -diciembre de 2018) referidos a CMTN en América Latina, buscó describir sus factores de riesgo asociados a este subtipo. Sus conclusiones se pueden resumir en que las mujeres latinas generalmente son diagnosticadas con CM a una edad más joven (56 vs 63 años para las mujeres BNH) y en etapas más avanzadas que las mujeres BNH.…”

Abordaje de la enfermedad cardiovascular en mujeres con cáncer de mama. Posición de la Asociación Nacional de Cardiólogos de México (ANCAM)

“…29 In Latin women, physical activity decreases the risk of BC, regardless of subtype. 30 Obesity. Overweight and obesity (O&O) are the main risk factors for CVD.…”

“…20,32,34 In the premenopause increase the risk of triple negative BC; in the post menopause the positive subtype www.medigraphic.org.mx to hormone receptors (39% increase) and the inflammatory in both. 30 Smoking. The prevalence of smoking in Mexican women is 9.9%.…”