Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs

Silva, Denise Rossato; Muñoz-Torrico, Marcela; Duarte, Raquel; Galvão, Tatiana Senna; Bonini, Eduardo Henrique; Arbex, Flávio; Arbex, Marcos Abdo; Augusto, Valéria Maria; Rabahi, Marcelo Fouad; Mello, Fernanda Carvalho de Queiroz

doi:10.1590/s1806-37562017000000443

Cited by 191 publications

(193 citation statements)

References 57 publications

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“…In Montes Claros-MG, it was observed that of 661 patients with tuberculosis, 60.4% of the patients were male [16]. This predominance of males has been associated with cultural issues, due to alcohol and/or tobacco consumption, which may compromise immunity and nutritional status, and thus increase the likelihood of acquiring tuberculosis [17].…”

Section: Resultsmentioning

confidence: 99%

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Júnior

Alves

Farias³

et al. 2019

Sci. Plena

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The present study aimed to elucidate the epidemiological profile of tuberculosis patients in Natal-RN between the years 2010 and 2018. This was an epidemiological, retrospective and documentary study, in which the recovery of the secondary data occurred from the "Departamento de Informática do Sistema Único de Saúde (DATASUS)" in Brazil. The following variables were studied: year of notification, gender, age, schooling, area of residence, ethnicity and factors that facilitate the onset of tuberculosis. Statistical association was performed using the Chi-Square test. In the year 2011, the highest percentage of notifications for tuberculosis was received (12.4%) in Natal-RN. The profile of the affected individuals was predominantly male (69.5%), between 20 and 39 years of age (43.8%), low educational levels (41.3%), mulattoes (68.2%) and urban residents (94.1%). When gender was associated with factors that facilitate the onset of tuberculosis, it was observed that males presented higher percentages of positivity for Human Immunodeficiency Virus (HIV) (16.3%), Acquired immunodeficiency syndrome (AIDS) (15.8%), alcoholism (34%) and smoking (13.5%), while in females the highest rates of this correlation were with Diabetes mellitus (10.4%). In addition, a statistically significant association was found between gender with tobacco and alcohol consumption (<0.001) and with the presence of diabetes and Aids (<0.001). The data found in this study may serve as an auxiliary for developing more specific public policies for those most susceptible to tuberculosis in Natal-RN.

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Section: Resultsmentioning

confidence: 99%

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Júnior

Alves

Farias³

et al. 2019

Sci. Plena

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“…Data point out to the impact of diabetes on the immune system, favoring the bacillus survival 27 . Diabetes causes increased susceptibility to TB through several mechanisms, including hyperglycemia and cellular insulinopenia, which have indirect effects on macrophage and lymphocyte function 27,28 . Diabetes is Mutations in the gyrA gene were also found in all the 41 samples, constituting the main mechanism of resistance to FQ, with specific mutations at codons 89, 90, 94 and 95.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil

Campelo

Lima

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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In Fortaleza, the capital of Ceara State, Brazil, the detection rate of tuberculosis (TB) in 2018 was 65.5/100,000 inhabitants with a cure rate of 59.1%, which is higher than the country average. This study investigated the risk factors associated with drug-resistant tuberculosis (DR-TB) and identified the drug-resistance phenotype and resistance-conferring mutations. The geographic distribution of DR-TB in Fortaleza, Brazil, was also determined. From March 2017 to February 2018, 41 DR-TB isolates and 69 drug-susceptible pulmonary TB isolates were obtained from patients seen at a referral hospital in Fortaleza, Brazil. Samples were subjected to phenotypic and genetic analysis of resistance; the spatial distribution of the participants was also analyzed. Primary resistance was high (50.9%) among participants. The following risk factors for DR were identified: being female (p = 0.03), having diabetes (p < 0.01), history of previous TB disease (p < 0.01), and the number of intra-domiciliary contacts (p < 0.01). Analysis by multiplex allele-specific polymerase chain reaction detected mutations in the genes katG (65.8%), rpoB (43.9%), inhA promoter (14.6%), and gyrA (9.8%). Sequencing identified mutations in the the genes katG (75.6%), inhA promoter (19.5%), rpoB (85.4%), and gyrA (100%). There was no mutation in the rrs gene. Spatial analysis showed DR-TB isolates distributed in areas of low socioeconomic status in the city of Fortaleza. Our results emphasized the importance of detecting resistance to TB drugs. The resistance found in the gene gyrA is of concern due to the high number of pre-extensive DR-TB cases in Fortaleza.

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“…Com relação à raça, os dados obtidos no presente estudo que evidenciam maior prevalência de TB na população branca (74,2%) divergem do estudo de Ferraz (14) que encontrou maior prevalência entre a população negra (76,7%), tal achado decorre, pois nos municípios estudados há predominância da população branca, pelo censo IBGE 2010, 84% da população de SC se declarara branca (21)(22) .…”

Section: Resultsunclassified

“…Quanto aos aspectos individuais, o uso de drogas, a ocorrência de outras doenças, www.ufsj.edu.br/recom -7 principalmente as crônicas são identificadas como contribuindo para a não adesão ao tratamento (22) .…”

Section: Resultsunclassified

Fatores sociodemográficos e de saúde de pessoas com tuberculose em três cidades no sul do Brasil

Souza

Böell

Suplici

et al. 2019

R. Enferm. Cent. O. Min.

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Objetivo: Descrever as características sociodemográficas de pessoas acometidas por tuberculose, de resposta ao tratamento e uso de substâncias nocivas à saúde, em três municípios prioritários no controle da doença, no Sul do Brasil.Método:Estudo transversal,descritivo-exploratório, realizado com 209 pessoas em tratamento de tuberculose. Aplicou-se instrumento para coletar dados sociodemográficose de saúde dos participantes. Realizada análise descritiva dos dados. Resultados: Os participantes possuíam em média, 44 anos (DP:16,1); em sua maioria solteiros (50,7%), com crença religiosa (91%), ativos economicamente (61,7%), com ensino fundamental (65%), renda média de 1.791,91 reais. Entre os participantes, 28,2% eram fumantes, enquanto 43,5% nunca fumaram; 53,4% negaram etilismo e 46,5% afirmaram o uso. Dos participantes, 56% eram de casos novos da doença, enquanto 7,7% apresentavam recidiva. Houve 78,5% que apresentaram cura ao final do tratamento e 3,8%, cujo tratamento não obteve resposta satisfatória, sendo 1,9 %, aqueles que evoluíram para óbito. Conclusão: Analisar o perfil das pessoas atendidas nessas cidades permitiu maior compreensão acerca da tuberculose, ampliando o olhar sobre o tratamento e acompanhamento de tais pacientes, bem como dos determinantes que estão intimamente relacionados ao curso da doença.

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Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs

Cited by 191 publications

References 57 publications

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil

Fatores sociodemográficos e de saúde de pessoas com tuberculose em três cidades no sul do Brasil

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