Risk factors for ventilator-associated pneumonia in neonatal intensive care unit patients

Kawanishi, Fumiko; Yoshinaga, Masami; Morita, Michiyo; Shibata, Yuriko; Yamada, Tomoyuki; Ooi, Yukimasa; Ukimura, Akira

doi:10.1016/j.jiac.2014.06.006

Cited by 24 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kawanishi et al 22 compared the VAP rate between 7-day and 14-day ventilator circuit changes, and found no significant difference (9.66 vs. 8.08 episodes per 1000 ventilator days). We change the ventilator circuit every 7 days in our NICU as routine practice, and the rate of VAP (7.1 episodes per 1000 ventilator days) was slightly lower than in the study of Kawanishi et al 22 VAP is thought to be associated with lower gestational age and lower birth weight due to the higher probability of intubation after birth. Geffers et al 18 reported 8677 very low birth weight infants from 52 neonatology departments in Germany.…”

Section: Discussionmentioning

confidence: 99%

Ventilator-Associated Pneumonia in Low Birth Weight Neonates at a Neonatal Intensive Care Unit: A Retrospective Observational Study

Lee

Chen

2017

Pediatrics & Neonatology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Ventilator-Associated Pneumonia in Low Birth Weight Neonates at a Neonatal Intensive Care Unit: A Retrospective Observational Study

Lee

Chen

2017

Pediatrics & Neonatology

View full text Add to dashboard Cite

show abstract

“…We followed the CDC strategies regarding ventilator care in our bundle. Similarly, recent study concluded that decreasing the ventilator circuit changes from every 7 days to every 14 days has no adverse effect on the rate of VAP in NICU [ 24 ]. Yuan and his team reported that the risk factors for the development of neonatal VAP were re-intubation, frequent ETT suctioning, and the duration of mechanical ventilation [ 25 ], Tan and his fellows proved the same findings [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Reducing ventilator-associated pneumonia in neonatal intensive care unit using “VAP prevention Bundle”: a cohort study

et al. 2015

View full text Add to dashboard Cite

BackgroundVentilator-associated pneumonia (VAP) is a serious health care- associated infection, resulting in high morbidity and mortality. It also prolongs hospital stay and drives up hospital costs. Measures employed in preventing ventilator- associated pneumonia in developing countries are rarely reported. In this study we tried to assess the efficacy of our designed “VAP prevention bundle” in reducing VAP rate in our neonatal intensive care unit (NICU).MethodThis prospective before-and-after study was conducted at university hospital NICU, all neonates who had mechanical ventilation for ≥ 48 h were eligible. VAP rates were evaluated before (phase-I) and after (phase-II) full implementation of comprehensive preventive measures specifically designed by our infection control team.ResultsOf 143 mechanically ventilated neonates, 73 patients developed VAP (51 %) throughout the study period (2500 mechanical ventilation days). The rate of VAP was significantly reduced from 67.8 % (42/62) corresponding to 36.4 VAP episodes/1000 mechanical ventilation days (MV days) in phase-I to 38.2 % (31/81) corresponding to 23 VAP/1000 MV days (RR 0.565, 95 % confidence interval 0.408-0.782, p = 0.0006) after VAP prevention bundle implementation (phase-II). Parallel significant reduction in MV days/case were documented in post-intervention period (21.50 ± 7.6 days in phase-I versus 10.36 ± 5.2 days in phase-II, p = 0.000). There were a trend toward reduction in NICU length of stay (23.9 ± 10.3 versus 22.8 ± 9.6 days, p = 0.56) and overall mortality (25 % versus 17.3 %, p = 0.215) between the two phases but didn’t reach statistical significance. The commonest micro-organisms isolated throughout the study were gram-negative bacteria (63/66, 95.5 %) particularly Klebsilla pneumonia (55/66, 83.4 %).ConclusionImplementation of multifaceted infection control bundle resulted in reduction of VAP rate, length of stay in our NICU.

show abstract

“…They found that 41.4% of the neonates who developed healthcare-associated infections weighed <1 kg [5]. In developing countries, the reported rates are significantly higher, ranging from 16.1 to 89 episodes per 1,000 ventilator days [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Neonatal Ventilator-Associated Pneumonia: An Underdiagnosed Problem in the Neonatal Intensive Care Units

Al‐Alaiyan¹

2017

JPNC

View full text Add to dashboard Cite

Ventilator-associated pneumonia (VAP) is one of the most common healthcareassociated infections among ventilated neonates. Remarkably, since there are no specific diagnostic criteria for the neonatal period, VAP criteria for infants <12 months have been generally applied to the newborn patient. The reported rate of VAP in neonates ranges from 2.7 episodes to 10.9 episodes per 1000 ventilator days and occurs more in preterm babies. Recognized risk factors of VAP in adults and children differ between studies; however Low birthweight, duration of mechanical ventilation, frequent suctioning, and reintubation have been consistently reported. Educational interventions and efforts to improve adherence to strategies of VAP for children have been associated with decreased VAP rates. This mini-review aims to give an understanding of the epidemiology, pathogenesis, diagnosis, and treatment of neonatal VAP.

show abstract

Risk factors for ventilator-associated pneumonia in neonatal intensive care unit patients

Cited by 24 publications

References 15 publications

Ventilator-Associated Pneumonia in Low Birth Weight Neonates at a Neonatal Intensive Care Unit: A Retrospective Observational Study

Ventilator-Associated Pneumonia in Low Birth Weight Neonates at a Neonatal Intensive Care Unit: A Retrospective Observational Study

Reducing ventilator-associated pneumonia in neonatal intensive care unit using “VAP prevention Bundle”: a cohort study

Neonatal Ventilator-Associated Pneumonia: An Underdiagnosed Problem in the Neonatal Intensive Care Units

Contact Info

Product

Resources

About