Risk factors for voice quality after radiotherapy for early glottic cancer

Boltežar, Irena Hočevar; Žargi, Miha; Strojan, Primož

doi:10.1016/j.radonc.2009.09.014

Cited by 39 publications

(43 citation statements)

References 23 publications

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“…No differences were found in the means of Ff, jitter, shimmer, or GNE between the groups, although overall licit drug users had changes in jitter and shimmer, which means a voice with roughness and hoarseness, results that match the literature 31,32 .…”

Section: Resultssupporting

confidence: 56%

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Uso de substâncias psicoativas, alterações vocais e qualidade de vida em usuários de drogas lícitas e ilícitas

et al. 2015

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OBJETIVOS:investigar a qualidade de vida e voz, além das principais alterações perceptivo-auditivas e as medidas acústicas jitter, shimmer e Glottal Noise Excitation em usuários de substâncias psicoativas lícitas e/ou ilícitas que buscaram um centro de tratamento para dependência química.MÉTODOS:estudo transversal. Os participantes responderam aos questionários de Mensuração de Qualidade de Vida em Voze World Health Organization Quality of Life Instrument-Bref. Além disso foi realizado, um registro vocal da vogal /a/ e de uma contagem de números de 1 a 20. Os registros vocais foram avaliados por meio da escala GRBAS-I (G - grau global da disfonia, R - rugosidade, B - soprosidade, A - astenia, S - tensão) e a análise acústica (jitter, shimmer, Glottal noise excitation) pelo software VoxMetria.RESULTADOS:avaliaram-se 29 protocolos e registros de voz; na amostra, 19 (65,5%) eram homens; a idade média da amostra foi de 37,8 anos. Os escores de ambos os questionários não apresentaram diferenças entre os usuários de drogas lícitas e os de drogas ilícitas. Na análise perceptiva por meio da GRBAS-I, eles mostraram predominância de alterações discretas e moderadas nos itens grau geral da disfonia, rugosidade e instabilidade para usuárias de drogas ilícitas. A medida acústica jitter e o shimmerestavam alterados para homens e mulheres, e o desvio padrão da frequência fundamental também estava alterado.CONCLUSÃO:alterações de qualidade de vida e voz foram identificadas em ambos os usuários. A maioria dos usuários apresentou alterações nas medidas de jittere shimmer.Usuários de drogas ilícitas apresentaram mais alterações de Glottal Noise Excitation e desvio padrão da frequência fundamental.

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Section: Resultssupporting

confidence: 56%

“…The increase in shimmer may be linked to an inconsistency in the vocal fold contact 37 . The aggression caused by the heat of the smoke and by the substances present in tobacco, such as nicotine, make the mucosa defend itself by producing keratosis, which ends up increasing its thickness and reducing its elasticity and flexibility 31,32 .…”

Section: Resultsmentioning

confidence: 99%

Uso de substâncias psicoativas, alterações vocais e qualidade de vida em usuários de drogas lícitas e ilícitas

et al. 2015

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“…Findings from this body of research suggests that both methods of organ-preservation treatment impact vocal quality and function to a similar extent, with the majority of patients expected to present with persistent, predominantly mildmoderate changes to voice quality [7][8][9]. Whilst numerous mechanisms relating to either the radiotherapy or surgical procedures have been proposed to be the cause of such vocal change, few studies have explored the potential impact of the earliest procedure on patient outcomes, that of the biopsy [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…An excisional biopsy removes the entire pathological tissue whilst endeavouring to preserve structures of the vocal cords and is argued to be superior to the punch biopsy which may harm the vocal cords [14]. Vocal cord stripping (removal of the top most layers of tissue along the vocal cords) may also occur as a biopsy procedure [12,13,18].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous authors lay claim that the biopsy process may influence voice and functional outcomes [11][12][13]18], however the possible biopsy-voice impact has not been systematically investigated in a single study to date. All studies, discussing the impact of the biopsy, have been retrospective and were designed to explore post cancer treatment voice outcomes, with the potential for possible impact from the biopsy procedure only discussed as a post hoc, secondary measure.…”

Section: Introductionmentioning

confidence: 99%

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The impact of laryngeal biopsy on voice outcomes: a pilot study

Bergström¹,

Ward²,

Finizia³

2016

Otorhinolaryngol Head Neck Surg

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Objective: Several studies have suggested that type of laryngeal biopsy may impact voice and vocal function, which may ultimately influence functional outcomes post cancer treatment. This study directly examined the impact of the biopsy procedure on voice outcomes for early glottic (Tis-T2) cancer patients.Design: Prospective pilot cohort study. Method:Fifteen patients diagnosed with early glottic cancer underwent voice recordings within one week pre-biopsy and between one-six weeks post-biopsy, via Sahlgrenska University Hospital, Sweden. A control group (n=15), matched for gender and comparable for age and smoking status, was assessed once only. Multidimensional voice analyses were conducted with both groups including: (1) Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS) perceptual rating, (2) acoustic measures of harmonics to noise ratio, jitter, shimmer, mean spoken fundamental frequency and (3) Maximum Phonation Time (MPT). Results:In comparison to the control group, most perceptual and acoustic parameters were significantly (P<0.05) more impaired both pre and post biopsy. No significant difference (P>0.05) in the patient cohort was observed between pre-post biopsy voice parameters. At an individual level, half of the patients showed a perceived change in voice post biopsy, of which four demonstrated improvement and three a deterioration in vocal function. Implications:Although group level analysis did not show a significant biopsy-voice impact, individual data suggests that multiple, punch biopsies may negatively impact functional outcomes. The biopsy procedure is undoubtedly a necessary first step in laryngeal cancer management; however, given the emerging discussion regarding the type of biopsy technique, the nature and the extent of tumour/tissue removal on functional outcomes, this is an area for further research.

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Laser surgery for early to moderately advanced glottic, supraglottic, and hypopharyngeal cancers

et al. 2011

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Current practice standards for the treatment of early to moderately advanced laryngeal and hypopharyngeal cancer demand both achievement of cure and preservation of laryngeal structure and function to the greatest extent possible. The oncologic and functional results of transoral laser microsurgery (TLM) for early glottic cancer appear to be comparable to those of radiotherapy, with a higher rate of laryngeal preservation and a lower cost. TLM for early and moderately advanced supraglottic and hypopharyngeal cancers offers similar results with regard to survival and local control to those obtained with open surgical approaches. In addition, functional results of TLM are superior to those of open approaches because tracheotomies are usually avoided, rehabilitation of swallowing is faster, and hospital stay is shorter. TLM, when applicable, has become the preferred modality for surgical treatment of most early to moderately advanced cancers of the larynx and selected tumors of the hypopharynx.

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Risk factors for voice quality after radiotherapy for early glottic cancer

Cited by 39 publications

References 23 publications

Uso de substâncias psicoativas, alterações vocais e qualidade de vida em usuários de drogas lícitas e ilícitas

Uso de substâncias psicoativas, alterações vocais e qualidade de vida em usuários de drogas lícitas e ilícitas

The impact of laryngeal biopsy on voice outcomes: a pilot study

Laser surgery for early to moderately advanced glottic, supraglottic, and hypopharyngeal cancers

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